Results 111 to 120 of about 7,935 (218)

Methotrexate for Maintaining Remission in Paediatric Crohn's Patients with Prior Failure or Intolerance to Thiopurines: A Multicenter Cohort Study

, 2015
Background and aims: Methotrexate [MTX] is an immunomodulating drug that can be used to maintain remission in patients with Crohn's disease [CD], but data on efficacy and tolerability in children and teenagers are scarce.
Norbruis, O, Lijftogt, T., Ridder, Lissy de, Hendriks, Danielle, Lijftogt, T, Haisma, S.M., George, E., de Ridder, L., Ridder, L. de, Damen, G., Meij, Tim de, George, Elvira, Hummel, T, Mearin, M.L., Mearin, ML, Haisma, Sjoukje-Marije, de Meij, T.G.J., Lijftogt, Thijs, Norbruis, Obbe, Rheenen, P., Hummel, Thalia, de Meij, Tim, Meij, T. de, Damen, Gerard, Mearin, M. Luisa, Escher, J.C., Haisma, SM, Escher, Johanna C., de Meij, T, Kindermann, A, Escher, Hankje, van Rheenen, Patrick, van Rheenen, P., Norbruis, O., Kindermann, Angelika, George, E, de Ridder, Lissy, Hummel, T., van Rheenen, Patrick; id_orcid, van Rheenen, P, Hendriks, D., Kindermann, A.   +41 more
core   +1 more source

Thiopurines: Factors influencing toxicity and response

, 2010
Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed ...
Coulthard, Sally A,, Albertioni, Freidoun,, Kambiz Fotoohi, Alan,   +2 more
core   +1 more source

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease [PDF]

Crohn's & Colitis 360, 2020
openaire   +2 more sources

Thiopurines: Factors influencing toxicity and response

Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed ...
Coulthard SA, Fotoohi AK, Albertioni F
core   +4 more sources

Thiopurines

, 2015
promotiedatum: 4-12-2015 prom-id ...
openaire   +2 more sources

A Phase Ib/II Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden. [PDF]

Cancer Res Commun
Secher CF, Højgaard M, Spanggaard I, Schmidt AY, Guo Y, Robinson L, De Zio D, Toksvang LN, Bagger FO, Schmiegelow K, Rohrberg KS.   +10 more
europepmc   +1 more source

Is it time to move away from legacy inflammatory bowel disease drugs? [PDF]

Singapore Med J
Leung WK.
europepmc   +1 more source

Dual Therapy for Complex Inflammatory Bowel Disease: Safety, Clinical and Steroid-Free Response. [PDF]

Clin Exp Gastroenterol
Haase AM, Kelsen J, Agnholt J, Bendix M.
europepmc   +1 more source

Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report. [PDF]

Clin Transl Sci
Fry J, Boone EC, Wang WY, John S, Lansdon LA, Farooqi MS, Yoo B, Gaedigk A, August K, Flatt TG, Ramsey LB.   +10 more
europepmc   +1 more source

Acquired Immunodeficiency in Newborn Following Intrauterine Exposure to Thiopurines for Treatment of Inflammatory Bowel Disease. [PDF]

ACG Case Rep J
Morand S, Lam MT, Amornsawadwattana S, Gutierrez A, Nguyen AA, Prockop S, Ruggiero J, Kitcharoensakkul M.   +7 more
europepmc   +1 more source