Results 21 to 30 of about 10,789 (224)

Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?

Frontiers in Medicine, 2021
Thiopurines have been a cornerstone in the treatment of inflammatory bowel disease (IBD). Although they have been used for more than 50 years, there are still some unsolved issues about their efficacy and, also, some safety concerns, mainly the risk of ...
Carla J. Gargallo-Puyuelo, Viviana Laredo, Fernando Gomollón, Fernando Gomollón, Fernando Gomollón, Fernando Gomollón   +5 more
doaj   +1 more source

Risk of malignancies in patients with inflammatory bowel disease who used thiopurines as compared with other indications: a territory-wide study

Therapeutic Advances in Gastroenterology, 2020
Aims: Thiopurines are believed to increase cancer risks, but data from Asian patients are sparse. We determined the risks of malignancies in thiopurine users with inflammatory bowel disease (IBD) or other indications from Hong Kong. Methods: All patients
Kelvin Y. C. Zheng, Chuan-Guo Guo, Irene O. L. Wong, Lijia Chen, Ho Yin Chung, Ka Shing Cheung, Wai K. Leung   +6 more
doaj   +1 more source

Pharmacogenomic tests of oncology drugs at Instituto Nacional de Câncer (INCA)

Brazilian Journal of Oncology, 2021
The implementation, current status and future perspectives of the pharmacogenetics/genomics (PGx) testing program developed at Instituto Nacional de Cancer (INCA) are presented. Initial selection of drug-gene pairs for PGx testing was based on clinically-
Guilherme Suarez-Kurtz
doaj   +1 more source

Use of thiopurines and risk of colorectal neoplasia in patients with inflammatory bowel diseases: a meta-analysis. [PDF]

PLoS ONE, 2013
ObjectiveInflammatory bowel disease (IBD) is commonly treated with thiopurines such as azathioprine and mercaptopurine for the maintenance of remission.
Jianfeng Gong, Lijing Zhu, Zhen Guo, Yi Li, Weiming Zhu, Ning Li, Jieshou Li   +6 more
doaj   +1 more source

Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis

Future Science OA, 2023
Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis.
Mona Boudabbous, Baha Barkia, Wiem Feki, Héla Gdoura, Lassad Chtourou, Manel Moalla, Leila Mnif, Ali Amouri, Zeinab Mnif, Nabil Tahri   +9 more
doaj   +1 more source

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml, A.A. van Bodegraven, Al Hadithy AF, Artlich A, Bean RHD, Buffet C, C.J.J. Mulder, Carter MJ, Daniel F, De Boer N, de Boer NK, de Boer NK, de Jong D, Derijks LJ, Dervieux T, Dubinsky MC, Ferlitsch A, Fonseca V, Gane E, Gearry RB, H. Vogelsang, Haboubi NY, Herrlinger KR, Herrlinger KR, Herrlinger KR, J. Seiderer, Jones MC, K.R. Herrlinger, Katzka DA, Lilleyman JS, M. Lukas, M. Schwab, Marinaki AM, McBride KL, N.K.H. de Boer, Naber AH, P. Knoflach, Russmann S, Rutgeerts P, S. Almer, S.W. van der Merwe, Sandborn W, Schaeffeler E, Seiderer J, Shastri S, T. Ochsenkühn, Teml A, Teml A, Teml A, Tiede I, van Dieren JM, W. Petritsch, W. Reinisch   +52 more
core   +1 more source

The Thiopurine Tale: An Unexpected Journey [PDF]

Journal of Crohn's and Colitis, 2022
Abstract Exactly 70 years ago [1951] mercaptopurine was discovered by Gertrude Elion as a novel treatment option for acute leukaemia. A total of three thiopurines (also thioguanine [1950] and azathioprine [1957]) were developed over time.
Femke Crouwel, Hans J C Buiter, Nanne K de Boer   +2 more
openaire   +3 more sources

Diagnosis and outcome of oesophageal Crohn's disease [PDF]

, 2019
BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement.
Beaton, D, Chaparro, M, Ellul, P, Katsanos, K, Oliveira, AM, et al., Rodrigues, R, Savarino, E, Sladek, M, Teich, N, van der Woude, J, Vavricka, R, Wei, J   +11 more
core   +1 more source

Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID) [PDF]

Intestinal Research, 2015
Background/AimsFor decades, thiopurines have been the mainstay of inflammatory bowel disease (IBD) treatment and will play an important role in the future.
Kang-Moon Lee, You Sun Kim, Geom Seog Seo, Tae Oh Kim, Suk-Kyun Yang,   +5 more
doaj   +1 more source

A Validated HPLC–Diode Array Detection Method for Therapeutic Drug Monitoring of Thiopurines in Pediatric Patients: From Bench to Bedside

Metabolites, 2022
Thiopurine drugs are part of the therapeutic armamentarium for pediatric patients suffering from inflammatory bowel disease (IBD) and acute lymphoblastic leukemia (ALL).
Martina Franzin, Debora Curci, Marianna Lucafò, Matteo Bramuzzo, Marco Rabusin, Antonella Fabretto, Riccardo Addobbati, Gabriele Stocco, Giuliana Decorti   +8 more
doaj   +1 more source