Results 21 to 30 of about 7,935 (218)
Frontiers in Medicine, 2022 Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with ...
Xin-Hui Khoo +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo +11 more
doaj +1 more source
Use of thiopurines in inflammatory bowel disease: an update [PDF]
Intestinal Research, 2022 Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Arshdeep Singh +25 more
doaj +1 more source
Use of thiopurines in inflammatory bowel disease [PDF]
, 2013 The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis.
Frei, Pascal +3 more
core +1 more source
Thiopurines and inhibition of Rac1 in vascular disease [PDF]
, 2015 The mechanism of immunosuppressive drug azathioprine is not clear, while azathioprine has been used for 60 years in clinical practice in patients undergoing transplantation surgery or to combat autoimmune disease.
Marinković, G.
core +15 more sources
Molecules, 2017 Azathioprine is the main thiopurine drug used in the treatment of immune-based inflammations of gastrointestinal tract. For the purpose of therapy control and optimization, effective and reliable analytical methods for a rapid drug monitoring in ...
Katarína Maráková +3 more
doaj +1 more source
Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]
, 2010 Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
Cordell, Samantha J. +11 more
core +1 more source
Thiopurines for inflammatory bowel disease:Role of pharmacogenetics
, 2005 There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S-methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to
Brouwers, J. R B J +2 more
core +2 more sources
PLoS ONE, 2016 ObjectiveLong-term treatment with thiopurines is associated with a decreased risk of Crohn's disease (CD) flare but an increased risk of various cancers depending on gender, age, and presence of extensive colitis.
Julien Kirchgesner +6 more
doaj +1 more source
Characterization of de novo colonic stricture due to Crohn’s disease
The Turkish Journal of Gastroenterology, 2014 Background/Aims: The development of colonic stenosis is a rare complication of Crohn’s disease (CD) without a surgical anastomosis history. So, the management and long-term follow-up results of colonic stricture due to CD have not been clearly ...
Metin Başaranoğlu +7 more
doaj +1 more source