Results 41 to 50 of about 2,479 (192)

Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine-Induced Myelosuppression in Australia: A Budget Impact Analysis. [PDF]

Clin Transl Sci
ABSTRACT Testing thiopurine methyltransferase (TPMT) enzyme activity or genotype prior to thiopurine prescribing is recommended to reduce the risk of moderate to severe—and potentially fatal—myelosuppression in poor or intermediate TPMT metabolizers. Despite this, only about one‐third of individuals prescribed thiopurines in Australia currently receive
Ianni BD, Ali MA, Yiu CH, Tan ECK, Lu CY.   +4 more
europepmc   +2 more sources

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology [PDF]

, 2019
The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients.
Kiel, Patrick J., Medeiros, Elizabeth B., Pratt, Victoria M., Schneider, Bryan P., Shen, Fei, Skaar, Todd C., Stansberry, Wesley M., Swart, Marelize   +7 more
core   +1 more source

Use of thiopurines in inflammatory bowel disease : an update [PDF]

, 2021
Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Ahuja, Vineet, Anand, Abhinav, Arkkila, Perttu, Banerjee, Rupa, Bernstein, Charles N., Desai, Devendra, Dutta, Amit Kumar, Dutta, Usha, Hanauer, Stephen, Kaur, Kirandeep, Kedia, Saurabh, Kochhar, Rakesh, Mahajan, Ramit, Mak, Joyce W. Y., Makharia, Govind, Mehta, Varun, Midha, Vandana, Ng, Siew Chien, Pai, C. Ganesh, Peddi, Kiran, Ranjan, Mukesh Kumar, Singh, Arshdeep, Sinha, Saroj Kant, Sood, Ajit, Tevethia, Harsh Vardhan, Verma, Suhang   +25 more
core   +1 more source

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

Frontiers in Pediatrics, 2021
Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients.
Xiaoyan Mao, Xiaoyan Mao, Runxiu Yin, Gaoyuan Sun, Yan Zhou, Chunhui Yang, Chunlian Fang, Yuhong Wu, Tingting Cui, Li Liu, Jiaxin Gan, Xin Tian   +11 more
doaj   +1 more source

Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.

PLoS ONE, 2020
IntroductionThe nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate.
Juliana Carla Gomes Rodrigues, Tatiane Piedade de Souza, Lucas Favacho Pastana, André Maurício Ribeiro Dos Santos, Marianne Rodrigues Fernandes, Pablo Pinto, Alayde Vieira Wanderley, Sandro José de Souza, José Eduardo Kroll, Adenilson Leão Pereira, Leandro Magalhães, Laís Reis das Mercês, Amanda Ferreira Vidal, Tatiana Vinasco-Sandoval, Giovanna Chaves Cavalcante, João Farias Guerreiro, Paulo Pimentel de Assumpção, Ândrea Ribeiro-Dos-Santos, Sidney Santos, Ney Pereira Carneiro Dos Santos   +19 more
doaj   +1 more source

Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion [PDF]

, 2013
PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion.
Bertoletto, Paulo Roberto, Chaves, José Carlos, Fagundes, Djalma José, Ikejiri, Adauto Tsutomu, Somaio Neto, Frederico, Taha, Murched Omar, Teruya, Roberto   +6 more
core   +2 more sources

Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review [PDF]

Precision and Future Medicine, 2021
The development of treatment options has revolutionized the prognosis of inflammatory bowel disease (IBD). However, a particular group of patients still experience therapeutic failure or drug side effects.
Ji Young Chang, Jae Hee Cheon
doaj   +1 more source

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]

, 2016
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H, Chang, Jenny, Den Hollander, Petra, Fuqua, Suzanne, Hartman, Zachary C, Hill, Jamal, Hilsenbeck, Susan G, Kent Osborne, C, Mazumdar, Abhijit, Mills, Gordon B, Poage, Graham M, Shepherd, Jonathan, Tsimelzon, Anna, Zhang, Yun   +13 more
core   +2 more sources

NUDT15: a novel player in thiopurine metabolism

Journal of Gastrointestinal and Liver Diseases, 2016
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Meijer, Berrie, Mulder, Chris J. J., de Boer, Nanne K. H.   +2 more
openaire   +3 more sources

6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients [PDF]

, 2017
Background and Aim: Thiopurines have a favorable benefit–risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically ...
Bodegraven, A.A. (Ad) van, Boer, K.H.N. (Nanne) de, Bouma, G. (Gerd), Derijks, L.J.J., Kreijne, J.E. (Joany), Meijer, B. (Berrie), Mulder, C.J.J. (Chris), van Moorsel, S.A.W. (Sofia A W), Wong, D.R. (Dennis R), Woude, C.J. (Janneke) van der   +9 more
core   +3 more sources