Results 41 to 50 of about 1,959 (184)

Benchmark of Open-Access Star-Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies. [PDF]

Clin Pharmacol Ther
Genetic polymorphisms are common in pharmacogenes, with sometimes important implications for drug metabolism. Assessing the correct enzyme phenotype from genetic data is thus a crucial step into the development of personalized medicine. Many bioinformatics star‐allele callers have been developed for this purpose of identifying the correct star alleles ...
Gros-La-Faige MB, Génin E, Herzig AF.
europepmc   +2 more sources

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

Frontiers in Pediatrics, 2021
Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients.
Xiaoyan Mao, Xiaoyan Mao, Runxiu Yin, Gaoyuan Sun, Yan Zhou, Chunhui Yang, Chunlian Fang, Yuhong Wu, Tingting Cui, Li Liu, Jiaxin Gan, Xin Tian   +11 more
doaj   +1 more source

NUDT15: a novel player in thiopurine metabolism

Journal of Gastrointestinal and Liver Diseases, 2016
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Meijer, Berrie, Mulder, Chris J. J., de Boer, Nanne K. H.   +2 more
openaire   +3 more sources

DataSheet1_Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations.docx

, 2021
Backgound: The high incidence of thiopurine-induced myelosuppression in Asians is known to be attributable to genetic variation in thiopurine metabolism.
Napat Laoaroon (11780597), Kunanya Suwannaying (11780594), Nathorn Chaiyakunapruk (551390), Sariya Udayachalerm (5713352), Wichittra Tassaneeyakul (551388), Apichaya Puangpetch (2837384), Patcharee Komvilaisak (11780588), Pitchayanan Kuwatjanakul (11780600), Su-on Chainansamit (11780591), Nontaya Nakkam (5596172), Chonlaphat Sukasem (2794669), Kanyarat Khaeso (5596187)   +11 more
core   +1 more source

Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review [PDF]

Precision and Future Medicine, 2021
The development of treatment options has revolutionized the prognosis of inflammatory bowel disease (IBD). However, a particular group of patients still experience therapeutic failure or drug side effects.
Ji Young Chang, Jae Hee Cheon
doaj   +1 more source

NUDT15 Genetic Polymorphism as a Risk Factor for Early Neutropenia During Valganciclovir Prophylaxis in Lung Transplant Patients. [PDF]

Transpl Infect Dis
Background: Valganciclovir (VGCV) prophylaxis effectively prevents cytomegalovirus infection in lung transplant patients. However, VGCV-induced neutropenia causes early cessation.
Katsube Y, Umemura K, Urabe Y, Ono M, Katada Y, Hira D, Ohsumi A, Nakajima D, Tsuda M, Nakagawa S, Mizuno T, Nagao M, Date H, Terada T.   +13 more
europepmc   +2 more sources

The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia

Children, 2021
Mercaptopurine (MP) is a commonly used maintenance regimen for childhood acute lymphoblastic leukemia (ALL). However, 6-MP has a narrow therapeutic index, which causes dose-limiting toxicities in hematopoietic tissues.
Jae Min Lee, Ye Jee Shim, Do-Hoon Kim, Nani Jung, Jung-Sook Ha   +4 more
doaj   +1 more source

Mercaptopurine induced myelosuppression in a child with a NUDT15 rs116855232 homozygous variant

Journal of Oncology Pharmacy Practice, 2022
Introduction Mercaptopurine (6-MP) is the backbone of the consolidation and maintenance therapy for paediatric acute lymphoblastic leukaemia (ALL). Nevertheless, it can cause critical myelosuppression. Predicting adverse reactions to 6-MP often involves the investigation of pharmacogenetic variants; in ...
Navya Gupta, Latha Sneha Magatha, Dhaarani Jayaraman, Julius Xavier Scott, Sharon Benita Antony, Teena Koshy   +5 more
openaire   +5 more sources

NUDT15 as potential marker for pharmacogenetic-guided 6-mercaptopurine therapy in children with acute lymphoblastic leukemia in Serbia [PDF]

, 2023
Introduction: The NUDT15 is new pharmacogene of importance for 6-mercaptopurine therapy, given to children with acute lymphoblastic leukemia (ALL).
Jelovac, Marina, Ristivojević, Bojan, Pavlović, Đorđe, Zukić, Branka, Stanković, Biljana, Gašić, Vladimir, Kotur, Nikola, Tošić, Nataša, Pavlović, Sonja, Milošević, Goran   +9 more
core  

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

BMC Gastroenterology, 2021
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively.
Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma   +9 more
doaj   +1 more source