Results 1 to 10 of about 10,795 (251)

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand [PDF]

Clinical and Translational Science
Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases ...
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
doaj   +3 more sources

Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine

Therapeutics and Clinical Risk Management, 2023
Jennifer Gallardo-Cóndor,1 Pablo Naranjo,1 Sebastián Atarihuana,1 Dayana Coello,2 Patricia Guevara-Ramírez,3 Rodrigo Flores-Espinoza,4 Germán Burgos,5,6 Andrés López-Cortés,7,8 Alejandro Cabrera-Andrade9,10 1Facultad de Ingeniería y Ciencias Aplicadas ...
Gallardo-Cóndor J, Naranjo P, Atarihuana S, Coello D, Guevara-Ramírez P, Flores-Espinoza R, Burgos G, López-Cortés A, Cabrera-Andrade A   +8 more
doaj   +2 more sources

A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics

Scientific Reports, 2022
Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in ...
Sidharth Saxena, T. P. Krishna Murthy, C. R. Chandrashekhar, Lavan S. Patil, Abhinav Aditya, Rohit Shukla, Arvind Kumar Yadav, Tiratha Raj Singh, Mahesh Samantaray, Amutha Ramaswamy   +9 more
doaj   +2 more sources

Examination of the TPMT and NUDT15*3 Variants to Predict the Response to Thiopurines in an Italian Cohort of Patients with Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Thiopurines are employed in inflammatory bowel diseases (IBDs; Crohn’s disease, CD; ulcerative colitis, UC) to induce remission, prevent relapse, and reduce the steroid dosage, although they can sometimes be ineffective and present side effects.
Tavano F, Palmieri O, Latiano M, Gioffreda D, Latiano T, Guerra M, Martino G, Valvano MR, Bossa F, Perri F, Latiano A.   +10 more
europepmc   +2 more sources

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

BMC Gastroenterology, 2021
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively.
Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma   +9 more
doaj   +2 more sources

TPMT mRNA Expression: A Novel Prognostic Biomarker for Patients with Colon Cancer by Bioinformatics Analysis

International Journal of General Medicine, 2022
Wei Jia, Yi-Fu He, Xiao-Jun Qian, Jian Chen Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ...
Jia W, He YF, Qian XJ, Chen J
doaj   +2 more sources

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj   +2 more sources

Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy [PDF]

Frontiers in Pharmacology
BackgroundThiopurine drugs are widely used as immunosuppressants and chemotherapeutic agents in clinical practice, but their adverse effects significantly limit their clinical application. TPMT c.719A>G (rs1142345) and NUDT15 c.415C>T (rs116855232)
Chenyu Zhao, Chenyu Zhao, Hui Huang
doaj   +2 more sources

Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease [PDF]

The Saudi Journal of Gastroenterology
Background: Azathioprine, a common inflammatory bowel disease (IBD) treatment, carries a myelosuppression risk, particularly leukopenia. Thiopurine methyltransferase (TPMT) genotyping can predict azathioprine-induced leukopenia (AIL), but data on TPMT ...
Yaser K. Meeralam, Adnan. B. Al-Zanbagi, Mona Al Saedi, Mohammed Sulaimani, Abdulrahman Basfar, Wafi Almutawa, Sayeda H. Albelewi, Mohammed K. Shariff   +7 more
doaj   +2 more sources

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED, MANALK RASHEED, HASANEIN H GHALI   +2 more
doaj   +1 more source