Results 1 to 10 of about 5,467 (204)

Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency

Metabolites, 2023
Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides.
Debbie S. Deben, Luc J. J. Derijks, Bianca J. C. van den Bosch, Rob H. Creemers, Annick van Nunen, Adriaan A. van Bodegraven, Dennis R. Wong   +6 more
doaj   +2 more sources

Detection of Thiopurine S-Methyltransferase (TPMT) Polymorphisms TPMT*3A, TPMT*3B and TPMT*3C in Children with Acute Lymphoblastic Leukemia

مجلة كلية الطب, 2018
Background: Thiopurines are essential medications in Acute Lymphoblastic Leukemia (ALL) treatment protocols as anti-cancer agents since long time; however, their use might result in unexpected toxicities in ALL children due to the low thiopurine S ...
Nawar S. Mohammed, Manal K. Rasheed, Hasanein H. Ghali, Shaymaa J. Ahmed    +3 more
doaj   +3 more sources

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines. [PDF]

PLoS ONE, 2017
Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as ...
Amit P Bhavsar, Erandika P Gunaretnam, Yuling Li, Jafar S Hasbullah, Bruce C Carleton, Colin J D Ross   +5 more
doaj   +2 more sources

Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2020
6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism.
Gabriela Burgueño-Rodríguez, Yessika Méndez, Natalia Olano, Agustín Dabezies, Bernardo Bertoni, Jorge Souto, Luis Castillo, Julio da Luz, Ana María Soler   +8 more
doaj   +2 more sources

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED, MANALK RASHEED, HASANEIN H GHALI   +2 more
doaj   +1 more source

Thiopurine-S-Methyltransferase Gene Polymorphism and Drug-related Toxicity in Children Treated for Acute Leukemia and Non-Hodgkin’s Lymphoma

Journal of Pediatric Research, 2022
Aim:Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene.
Eda Ataseven, Buket Kosova, Çağdaş Aktan, Zafer Kurugöl, Mehmet Kantar   +4 more
doaj   +1 more source

Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure. [PDF]

PLoS ONE, 2011
Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and ...
Amira Hosni-Ahmed, Joseph D Barnes, Jim Wan, Terreia S Jones   +3 more
doaj   +1 more source

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population [PDF]

Libyan Journal of Medicine, 2015
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene.
Hamza Ben Zeglam, Abdrazak Benhamer, Adel Aboud, Haitem Rtemi, Meftah Mattardi, Saleh Suleiman Saleh, Abdullah Bashein, Nabil Enattah   +7 more
doaj   +1 more source

Thiopurine -methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population

Therapeutic Advances in Gastroenterology, 2020
Background: Thiopurine methyltransferase (TPMT) plays a significant role in the metabolism of thiopurines, and, for patients with inflammatory bowel disease (IBD), it is useful to perform TPMT genotyping prior to azathioprine (AZA) treatment.
Polina Zalizko, Juris Stefanovics, Jelizaveta Sokolovska, Natalia Paramonova, Evija Klavina, Renars Erts, Vita Rovite, Janis Klovins, Aldis Pukitis   +8 more
doaj   +1 more source

Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis. [PDF]

PLoS ONE, 2015
Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in AZA metabolism.
Yue-Ping Liu, Han-Qing Xu, Ming Li, Xiang Yang, Shu Yu, Wei-Ling Fu, Qing Huang   +6 more
doaj   +1 more source