Results 11 to 20 of about 10,795 (251)

Detection of Thiopurine S-Methyltransferase (TPMT) Polymorphisms TPMT*3A, TPMT*3B and TPMT*3C in Children with Acute Lymphoblastic Leukemia

مجلة كلية الطب, 2018
Background: Thiopurines are essential medications in Acute Lymphoblastic Leukemia (ALL) treatment protocols as anti-cancer agents since long time; however, their use might result in unexpected toxicities in ALL children due to the low thiopurine S ...
Nawar S. Mohammed, Manal K. Rasheed, Hasanein H. Ghali, Shaymaa J. Ahmed    +3 more
doaj   +3 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update. [PDF]

Clin Pharmacol Ther
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maillard M, Schwab M, Whirl-Carrillo M, Moyer AM, Suarez-Kurtz G, Pui CH, Stein CM, Klein TE, Spahn C, Kwon S, Hartono JL, de Boer NK, Ahmad T, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.   +18 more
europepmc   +2 more sources

Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine-Induced Myelosuppression in Australia: A Budget Impact Analysis. [PDF]

Clin Transl Sci
ABSTRACT Testing thiopurine methyltransferase (TPMT) enzyme activity or genotype prior to thiopurine prescribing is recommended to reduce the risk of moderate to severe—and potentially fatal—myelosuppression in poor or intermediate TPMT metabolizers. Despite this, only about one‐third of individuals prescribed thiopurines in Australia currently receive
Ianni BD, Ali MA, Yiu CH, Tan ECK, Lu CY.   +4 more
europepmc   +2 more sources

Analytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation in Pediatric Oncology. [PDF]

Clin Transl Sci
Selection and validation of a whole genome sequencing pharmacogenomics annotation tool. ABSTRACT Whole genome sequencing (WGS) is increasingly accessible in clinical practice, enabling pharmacogenomics (PGx) integration, including in pediatric oncology.
Diekstra MHM, Biesot N, Donders J, Verwiel ETP, Janse A, Huitema ADR, Hanff LM, Tops BBJ, Kemmeren P, Hehir-Kwa JY.   +9 more
europepmc   +2 more sources

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment. [PDF]

Clin Transl Sci
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Khaeso K, Chainansamit SO, Kuwatjanakul P, Komvilaisak P, Nakkam N, Suwannaying K, Vannaprasaht S, Dornsena A, Tassaneeyakul W.   +8 more
europepmc   +2 more sources

Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion

Journal of Biological Chemistry, 2023
It is known that the recommended dietary allowance of selenium (Se) is dangerously close to its tolerable upper intake level. Se is detoxified and excreted in urine as trimethylselenonium ion (TMSe) when the amount ingested exceeds the nutritional level.
Yasunori Fukumoto, Rin Kyono, Yuka Shibukawa, Yu-Ki Tanaka, Noriyuki Suzuki, Y. Ogra   +5 more
semanticscholar   +1 more source

Preemptive TPMT Genotyping and Adherence to Genotype-Based Therapeutic Recommendations Reduces the Healthcare Cost in Patients Receiving Azathioprine or 6-Mercaptopurine for Autoimmune Diseases

Journal of Personalized Medicine, 2023
A cost analysis of thiopurine treatment was carried out in 257 patients, with 153 preemptively genotyped for TPMT and 104 retrospectively genotyped in a Spanish setting.
S. Valdez-Acosta, P. Zubiaur, M. Casado, J. Novalbos, A. Casajús, Diana Campodónico, I. Oyagüez, F. Abad‐Santos   +7 more
semanticscholar   +1 more source

Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency

Metabolites, 2023
Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides.
Debbie S. Deben, Luc J. J. Derijks, Bianca J. C. van den Bosch, Rob H. Creemers, Annick van Nunen, Adriaan A. van Bodegraven, Dennis R. Wong   +6 more
doaj   +1 more source

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines. [PDF]

PLoS ONE, 2017
Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as ...
Amit P Bhavsar, Erandika P Gunaretnam, Yuling Li, Jafar S Hasbullah, Bruce C Carleton, Colin J D Ross   +5 more
doaj   +1 more source

Thiopurine-S-Methyltransferase Gene Polymorphism and Drug-related Toxicity in Children Treated for Acute Leukemia and Non-Hodgkin’s Lymphoma

Journal of Pediatric Research, 2022
Aim:Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene.
Eda Ataseven, Buket Kosova, Çağdaş Aktan, Zafer Kurugöl, Mehmet Kantar   +4 more
doaj   +1 more source