Results 31 to 40 of about 5,467 (204)
TPMT in the treatment of Crohn's disease with azathioprine [PDF]
Gut, 2002 Azathioprine induced profound myelosuppression linked to TPMT deficiency has now been documented in many patient groups, including those with Crohn's disease. At the start of azathioprine or mercaptopurine therapy, measurement of TPMT activity has a role in identifying the 1 in 300 patients who are at risk of severe myelosuppression when treated with ...
openaire +2 more sources
TPMT status determination: The simplest is the most effective? [PDF]
Journal of Crohn's and Colitis, 2012 Dear Sir, We carefully read the article by Hindorf and Appell stating that genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase (TPMT) function.1 As evidence since many years, TPMT status should be determined before a thiopurine treatment to identify patients at risk for severe adverse events,
Laurent, Chouchana +2 more
openaire +2 more sources
Distribution of TPMT activity.
, 2018 TPMT activity in nmol/gHb/hr for patients with normal (gray) and heterozygous (black) TPMT genotype.
Jan Stephan F. Sanders (5076785) +3 more
core +1 more source
Importance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood.
Dokmanović Lidija +5 more
doaj +1 more source
Pharmacogenomic tests of oncology drugs at Instituto Nacional de Câncer (INCA)
Brazilian Journal of Oncology, 2021 The implementation, current status and future perspectives of the pharmacogenetics/genomics (PGx) testing program developed at Instituto Nacional de Cancer (INCA) are presented. Initial selection of drug-gene pairs for PGx testing was based on clinically-
Guilherme Suarez-Kurtz
doaj +1 more source
A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs
MetabolitesBackground: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell +2 more
doaj +1 more source
Therapeutics and Clinical Risk Management, 2023 Jennifer Gallardo-Cóndor,1 Pablo Naranjo,1 Sebastián Atarihuana,1 Dayana Coello,2 Patricia Guevara-Ramírez,3 Rodrigo Flores-Espinoza,4 Germán Burgos,5,6 Andrés López-Cortés,7,8 Alejandro Cabrera-Andrade9,10 1Facultad de Ingeniería y Ciencias Aplicadas ...
Gallardo-Cóndor J +8 more
doaj
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL [PDF]
Leukemia, 2003 A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ...
E Schaeffeler +6 more
openaire +1 more source
Relapse free survival for TPMT genotypes and tertiles of TPMT activity.
, 2018 Relapse free survival after start of cyclophosphamide induction therapy. Upper graph (3A): Variant = heterozygous TPMT variant carrier, Normal = normal genotype (wildtype TPMT).
Jan Stephan F. Sanders (5076785) +3 more
core +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source