Results 31 to 40 of about 10,795 (251)
Pharmacogenetics & Genomics, 2021 Supplemental Digital Content is available in the text. Thiopurines [e.g. 6-mercaptopurine (6MP)] are essential for the cure of acute lymphoblastic leukemia (ALL) but can cause dose-limiting hematopoietic toxicity.
Takaya Moriyama +7 more
semanticscholar +1 more source
Therapeutic Advances in Gastroenterology, 2020 Background: Thiopurine methyltransferase (TPMT) plays a significant role in the metabolism of thiopurines, and, for patients with inflammatory bowel disease (IBD), it is useful to perform TPMT genotyping prior to azathioprine (AZA) treatment.
Polina Zalizko +8 more
doaj +1 more source
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis. [PDF]
PLoS ONE, 2015 Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in AZA metabolism.
Yue-Ping Liu +6 more
doaj +1 more source
Genetic and Modifiable Risk Factors Contributing to Cisplatin-Induced Toxicities [PDF]
, 2019 Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other ...
Dinh, Paul C. Jr. +4 more
core +1 more source
Clinical pharmacology and therapy, 2019 Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines.
M. Relling +14 more
semanticscholar +1 more source
Frontiers in Pediatrics, 2021 Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients.
X. Mao +10 more
semanticscholar +1 more source
Pharmacogenomics and Personalized Medicine, 2021 Purpose Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is critical to preventing life-threatening infections and drug discontinuation.
Dewi Selvina Rosdiana +6 more
semanticscholar +1 more source
Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. [PDF]
PLoS ONE, 2015 Thiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs).
Yue-Ping Liu +8 more
doaj +1 more source
Pharmacogenomic tests in Oncology - finding the right dose
Brazilian Journal of Oncology, 2021 A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA).
Jeziel Basso, Gilberto Schwartsmann
doaj +1 more source
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source