Results 51 to 60 of about 5,467 (204)

Characterization of Tpmt^+/+, Tpmt^+/−, and Tpmt^−/− primary astrocyte cultures.

, 2013
(a) Micrograph image (200×) of primary astrocytes showing high astrocyte purity determined by GFAP (green) and propidium iodide (red) fluorescent staining.
Amira Hosni-Ahmed (336902), Joseph D. Barnes (336903), Terreia S. Jones (336905), Jim Wan (336904)   +3 more
core   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 914-929, October 2026.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Genomic Medicine Sweden: Advancing precision medicine at the national level

Journal of Internal Medicine, Volume 300, Issue 4, Page 397-419, October 2026.
Abstract High‐throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease‐causing genetic alterations and facilitating individualised treatment and care.
Anders Edsjö, Anna Lindstrand, Panagiotis Baliakas, David Gisselsson, Paula Mölling, Mia Wadelius, Åsa Johansson, Hannes Olauson, Hans Ehrencrona, Lovisa Lovmar, Christian G. Giske, Henrik Green, Ann Nordgren, Fulya Taylan, Martin Hallbeck, Erika Tång Hallbäck, Anna Green, Markus Heidenblad, Kina Höglund, Anders Jemt, Carl Mårten Lindqvist, Maria Johansson Soller, Magnus Sabel, Colum Walsh, Hartmut Vogt, Craig E. Wheelock, Martin Bergö, Jens Enoksson, Ann Ekberg Jansson, Cecilia Fagerström, Jan Holgersson, Stephanie Anja Juran, Mats G. Karlsson, Frida Lundmark, Eva Tiensuu Janson, Andreas Muranyi Scheutz, Malin Sund, Päivi Östling, Sofia Gruvberger‐Saal, Marene Landström, Malin Melin, Lars Palmqvist, Richard Palmqvist, Bianca Stenmark, Anna Wedell, Malin Karnå, Katarina Nyström, Tobias Strid, Per Sikora, Maria Johansson, Therese Fagerqvist, Mirja Carlsson Möller, Oskar Frisell, Mats Ulfendahl, Mikaela Friedman, Lucia Cavelier, Valtteri Wirta, Thoas Fioretos, Richard Rosenquist   +58 more
wiley   +1 more source

Structural Characteristics Determine the Cause of the Low Enzyme Activity of Two Thiopurine S-Methyltransferase Allelic Variants : A Biophysical Characterization of TPMT*2 and TPMT*5

, 2012
The enzyme thiopurine S-methyltransferase (TPMT) is involved in the metabolism of thiopurine drugs used to treat acute lymphoblastic leukemia and inflammatory bowel disease.
Hennig, Janosch,, Lindqvist Appell, Malin,, Dametto, Paolo,, Skoglund, Karin,, Mårtensson, Lars-Göran,, Wennerstrand, Patricia,, Klingstedt, Therése,   +6 more
core   +1 more source

A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics

Scientific Reports, 2022
Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in ...
Sidharth Saxena, T. P. Krishna Murthy, C. R. Chandrashekhar, Lavan S. Patil, Abhinav Aditya, Rohit Shukla, Arvind Kumar Yadav, Tiratha Raj Singh, Mahesh Samantaray, Amutha Ramaswamy   +9 more
doaj   +1 more source

Accelerated Biological Aging Increases the Risk of Head and Neck Cancer: Insights From Genetic Instruments of Epigenetic Clocks

Molecular Carcinogenesis, Volume 65, Issue 9, Page 1105-1113, September 2026.
ABSTRACT Epigenetic clocks are robust biomarkers of biological aging and have been associated with cancer susceptibility. However, the relationship between genetically predicted epigenetic age acceleration and head and neck cancer risk remains unclear. Using a large case‐control study of 2189 head and neck squamous cell carcinoma (HNSCC) cases and 2189
Jiaqi Wang, Jie Deng, Yifan Xu, Chia‐Wen Tsai, Wen‐Shin Chang, Yang Deng, Maosheng Huang, Da‐Tian Bau, Guojun Li, Jian Gu   +9 more
wiley   +1 more source

Benchmark of Open‐Access Star‐Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 520-530, August 2026.
Genetic polymorphisms are common in pharmacogenes, with sometimes important implications for drug metabolism. Assessing the correct enzyme phenotype from genetic data is thus a crucial step into the development of personalized medicine. Many bioinformatics star‐allele callers have been developed for this purpose of identifying the correct star alleles ...
Marc B. Gros‐La‐Faige, Emmanuelle Génin, Anthony F. Herzig   +2 more
wiley   +1 more source

Comparison of Tpmt-associated phenotypes in A172 isogenic cells.

, 2013
Tpmt protein activity was measured in A172mock and A172Tpmt cell lines.
Amira Hosni-Ahmed (336902), Joseph D. Barnes (336903), Terreia S. Jones (336905), Jim Wan (336904)   +3 more
core   +1 more source

Frequency of the most prevalent Thiopurine S-Methyl Trasferase alleles in referrals to Shariati Hospital in Tehran

Iranian South Medical Journal, 2009
Background: Patients with low or intermediate TPMT enzyme activity are at increased risk to develop severe hematopoietic toxicity after taking standard doses of thiopuring medications.
Mehdi Azadi, Saeed Kaviani, Masood Soleimani, Mehrdad Norouzi nia, Abbas Haji fathali   +4 more
doaj