Results 71 to 80 of about 5,467 (204)

The Association Between Azathioprine Genetic Polymorphisms, Clinical Efficacy and Adverse Drug Reactions Among Egyptian Patients with Autoimmune Diseases

Pharmacogenomics and Personalized Medicine, 2021
Nermeen Abuelsoud,1,2 Hala Fayed,3 Engy Elkateeb4 1Department of Clinical Pharmacy Practice, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; 2Department of Pharmacy Practice/Clinical Pharmacy, Faculty of Pharmacy, Egyptian Russian ...
Abuelsoud N, Fayed H, Elkateeb E
doaj  

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Explaining TPMT genotype/phenotype discrepancy by identification of a novel sequence variant, TPMT*27

, 2009
Thiopurine methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism of thiopurine drugs. Owing to polymorphisms in the TPMT gene (TPMT*2-*22), the enzyme activity varies interindividually.
Peterson, Curt,, Lindqvist Appell, Malin,, Lars-Göran, Mårtensson,, Skoglund, Karin,, Hertervig, Erik,, Wennerstrand, Patricia,   +5 more
core  

From Pharmacogenetics to Pharmacometabolomics: SAM Modulates TPMT Activity

Pharmacogenomics, 2014
In the present study, the influence of SAM on TPMT activity in vivo on human subjects was investigated.A total of 1017 donors from the Estonian Genome Center of the University of Tartu (Estonia) were genotyped for common TPMT variants, evaluated for TPMT activity, SAM levels, a set of 19 biochemical and ten hematological parameters and demographic data.
Karas-Kuželički, Nataša, Šmid, Alenka, Tamm, Riin, Metspalu, Andres, Mlinarič-Raščan, Irena   +4 more
openaire   +2 more sources

Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández, Agostina Zubiri‐Gaitán, Marina Martínez‐Álvaro, Agustín Blasco, Pilar Hernández   +4 more
wiley   +1 more source

Thiopurine Methyltransferase Enzyme Activity Determination before Treatment of Inflammatory Bowel Disease with Azathioprine: Effect on Cost and Adverse Events

Canadian Journal of Gastroenterology, 2005
BACKGROUND: Azathioprine (AZA), used to treat inflammatory bowel disease (IBD), is metabolized by thiopurine methyltransferase (TPMT). The accumulation of individual metabolites varies because humans display genetic polymorphism for TPMT expression ...
Farzana A Sayani, Connie Prosser, Robert J Bailey, Philip Jacobs, Richard N Fedorak   +4 more
doaj   +1 more source

TPMT mRNA Expression: A Novel Prognostic Biomarker for Patients with Colon Cancer by Bioinformatics Analysis

International Journal of General Medicine, 2022
Wei Jia, Yi-Fu He, Xiao-Jun Qian, Jian Chen Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of ...
Jia W, He YF, Qian XJ, Chen J
doaj  

Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes

Frontiers in Genetics, 2014
Background: The activity of thiopurine methyltransferase (TPMT) is subject to genetic variation. Loss-of-function alleles are associated with various degrees of myelosuppression after treatment with thiopurine drugs, thus genotype-based dosing ...
Berta eAlmoguera, Lyam eVazquez, John J Connolly, Jonathan eBradfield, Patrick eSleiman, Patrick eSleiman, Brendan eKeating, Hakon eHakonarson, Hakon eHakonarson   +8 more
doaj   +1 more source

Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT) [PDF]

, 1998
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines.
Vladimir M Belkov, Krynetski, Eugene Y, Belkov, Vladimir M, William E Evans, Fessing, Michael Y, Eugene Y Krynetski, Evans, William E, Michael Y Fessing   +7 more
core   +1 more source

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj