Results 91 to 100 of about 5,467 (204)

Rapid, long-range molecular haplotyping of thiopurine S-methyltransferase (TPMT) 3A, 3B, and 3C

, 2004
Background: Haplotyping is an important technique in molecular diagnostics because haplotypes are often more predictive for individual phenotypes than are the underlying single-nucleotide polymorphisms (SNPs). Until recently, methods for haplotyping SNPs
Armstrong, Victor William, von Ahsen, Nicolas, Oellerich, M.   +2 more
core   +1 more source

TPMT gen polimorfizminin Türk toplumunda incelenmesi

Amaç: TPMT (tiyopürin S-metiltransferaz) geni, tiyopürin grubu ilaçların metabolizmasında görevli sitozolik bir enzim olan tiyopürin S-metiltransferazı (EC 2.1.1.67) kodlamaktadır.
RUMEYSA ATASAY AYYILDIZ
core  

Comparison of thioguanine phenotypes in primary astrocyte cultures of each Tpmt genotype.

, 2013
(a) Primary astrocytes of each Tpmt genotype were exposed to thioguanine (TG) and cell viability was determined using the MTT assay.
Amira Hosni-Ahmed (336902), Joseph D. Barnes (336903), Terreia S. Jones (336905), Jim Wan (336904)   +3 more
core   +1 more source

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene

, 2010
Background The activity of the human enzyme thiopurine methyltransferase (TPMT) varies greatly between individuals because of genetic polymorphism.
Curt Peterson, Peterson, Curt,, Wennerstrand, Patricia, Malin Lindqvist Appell, Erik Hertervig, Mårtensson, Lars-Göran,, Patricia Wennerstrand, Lars-Göran Mårtensson, Appell, Malin Lindqvist, Martensson, Lars-Goran, Lindqvist Appell, Malin,, Hertervig, Erik, Peterson, Curt, Hertervig, Erik,, Lund University., Wennerstrand, Patricia,   +15 more
core   +1 more source

Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

Pakistan Journal of Medicine and Dentistry
Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza, Shamil Ashraf, Soofia Nigar, Itimad Abdelsalam Mohamed Ayed   +3 more
doaj   +1 more source

Thiopurine S-methyl Transferase (TPMT) Enzyme Level in Healthy Sudanese Population

Sudan Journal of Medical Sciences
Background: Thiopurine drugs have limited use due to their toxicity, related to the enzyme thiopurine S-methyl transferase (TPMT) activity, which varies between individuals.
Rayan Khalid, Nahla Hashim Hassan Erwa, Elshibli Mohamed Elshibli, Imad Fadl-Elmula   +3 more
doaj   +1 more source

Adverse events in relation to TPMT genotype.

, 2018
Adverse events in relation to TPMT genotype.
Jan Stephan F. Sanders (5076785), Abraham Rutgers (3562520), Coen A. Stegeman (344870), Arno C. Hessels (5076782)   +3 more
core   +1 more source

Genotypic and phenotypic analysis of the thiopurine S-methyltransferase (TPMT) gene with clinical correlation

, 2013
Immunosuppressants (such as azathioprine and 6‐mercaptopurine) are widely used in the management of patients having rheumatic diseases, inflammatory bowel diseases, hematological malignancies and organ transplant rejections.
張小屏, Cheung, Siu-ping
core   +1 more source

TPMT Gene [PDF]

, 2020
openaire   +1 more source

Analisi farmacogenetica dell’enzima TPMT in pazienti in trattamento con azatioprina [PDF]

, 2011
Introduzione. La comparsa di eventi avversi e il fallimento terapeutico sono problemi che si manifestano spesso in corso di trattamento con azatioprina (AZA) in pazienti affetti da malattie infiammatorie croniche reumatologiche e gastroenterologiche. AZA
GORI, GIOVANNI
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