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中枢神经系统脱髓鞘疾病患者TPMT基因突变与硫唑嘌呤所致毒副反应的关系
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要: 【目的】 探讨中枢神经系统脱髓鞘疾病患者巯代嘌呤甲基转移酶(TPMT)基因突变与硫唑嘌呤(AZA)所致的毒副反应之间的关系?【方法】 选择自2012年至2014年在中山大学附属第三医院就诊的224例患者(包括135例中枢神经系统脱髓鞘疾病患者和89例非中枢神经系统脱髓鞘疾病患者)进行前瞻性研究:给予中枢神经系统脱髓鞘疾病患者AZA口服(25 ~ 100 mg/d),观察2个月后出现的毒副反应情况;同时采用PCR-SNaPshot方法检测224例患者4种常见的TPMT突变等位基因TPMT *2 ...
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Farmacogenética do Gene TPMT na resposta A 6-Mercaptopurina, em pacientes com Leucemia Linfoblástica Aguda [PDF]
, 2016 Acute Lymphoblastic Leukemia (ALL) is the most common type of cancer in children under 15 years of age. 6-mercaptopurine (6-MP) is one of the most widely used chemotherapeutic agents in the treatment of childhood ALL.
LIMA, Carlos Henrique Vasconcelos de
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, 2012 U liječenju upalne bolesti crijeva koriste se tiopurinski lijekovi čija se doza često mora smanjiti ili se terapija mora prekinuti jer neki pacijenti razvijaju nuspojave.
Zoko, Nikolina
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