Results 121 to 130 of about 5,467 (204)

Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report. [PDF]

Clin Transl Sci
Fry J, Boone EC, Wang WY, John S, Lansdon LA, Farooqi MS, Yoo B, Gaedigk A, August K, Flatt TG, Ramsey LB.   +10 more
europepmc   +1 more source

硫唑嘌呤治疗系统性红斑狼疮的不良反应与硫嘌呤甲基转移酶活性的关系

Zhongshan Daxue xuebao. Yixue kexue ban, 2011
【目的】探讨硫唑嘌呤(AZA)在系统性红斑狼疮（SLE）维持治疗中的不良反应（ARD）以及与硫嘌呤甲基转移酶（TPMT）活性的关系。【方法】分析AZA在250例SLE患者维持治疗中的ARD发生特点，并应用高效液相色谱法（HPLC) 测定这部分患者红细胞TPMT 活性，分析TPMT活性与AZA所致不良反应的关系。【结果】最常见的ARD是血液系统损害（21例，8.4%），其次为胃肠道反应（19例，7.6%），肝功能异常（8例，3.2%）、脱发(5例，2.0%)，急性胰腺炎1例 ...
doaj  

From Genotype to Functional Risk: A Multi-Omic Approach to Predicting Thiopurine and Methotrexate Co-Therapy-Induced Liver Injury. [PDF]

Pharmaceuticals (Basel)
Molnár D, Reznik E, Porrogi P.
europepmc   +1 more source

Distribution of <i>NUDT15*4</i> in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs. [PDF]

Front Pharmacol
Suarez-Kurtz G, Elias ABR, Carvaho MA, Dias A, Gusmão L, Basta PC, Perini JA.   +6 more
europepmc   +1 more source

Clinical experience in the treatment and prognosis of seven cases of Cronkhite-Canada syndrome. [PDF]

Medicine (Baltimore)
Bae J, Kim M, Kim ER, Kim YH, Chang DK, Kim JE, Hong SN.   +6 more
europepmc   +1 more source

Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo. [PDF]

Hum Genome Var
Pasha F, Urbančič D, Gosheva G, Zhubi B, Maliqi Qormemeti S, Krasniqi S, Mlinarič-Raščan I.   +6 more
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update. [PDF]

Clin Pharmacol Ther
Maillard M, Schwab M, Whirl-Carrillo M, Moyer AM, Suarez-Kurtz G, Pui CH, Stein CM, Klein TE, Spahn C, Kwon S, Hartono JL, de Boer NK, Ahmad T, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.   +18 more
europepmc   +1 more source

Hilar and Mediastinal Lymphadenopathy as a Potential Manifestation of Azathioprine-Associated Hypersensitivity Syndrome. [PDF]

Pharmaceuticals (Basel)
Ziaka M.
europepmc   +1 more source

Association between genetically predicted expression of TPMT and azathioprine adverse events. [PDF]

BMC Pharmacol Toxicol
Steitz A, Daniel LL, Nepal P, Dickson AL, Zanussi J, Miller-Fleming TW, Straub PS, Wei WQ, Liu G, Maizel J, Cox NJ, Hung AM, Feng Q, Stein CM, Chung CP.   +14 more
europepmc   +1 more source

Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine-Induced Myelosuppression in Australia: A Budget Impact Analysis. [PDF]

Clin Transl Sci
Ianni BD, Ali MA, Yiu CH, Tan ECK, Lu CY.   +4 more
europepmc   +1 more source