Results 81 to 90 of about 5,467 (204)

TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience

Pharmacogenomics
To share the experience of a US national reference laboratory, offering genotyping for TPMT and NUDT15, TPMT enzyme phenotyping and detection of thiopurine metabolites.Retrospective review of archived datasets related to thiopurines drug therapy including patients' data that underwent TPMT and NUDT15 genotyping, and smaller data sets where genotyping ...
Shaaban, Sherin, Walker, Brandon S., Ji, Yuan, Johnson-Davis, Kamisha   +3 more
openaire   +3 more sources

In vitro studies of Thiopurine S-Methyltransferase: Ligand binding interactions and development of a new enzymatic activity assay for TPMTwt, TPMT*6 and TPMT*8

, 2015
Acute lymphoblastic leukemia, one of the most malignant cancer forms in children is commonly treated with the thiopurine 6-mercaptopurine (6-MP) in combination with a high dose of methotrexate (MTX).
Klasén, Johan, Hemmingsson, Lovisa
core   +2 more sources

Genetic Polymorphism of the Thiopurine S-Methyltransferase Gene: A Tertiary Care Setup Study

Pakistan Armed Forces Medical Journal
Objective: To determine Thiopurine s-Methyl Transferase (TPMT) gene variants in patients reporting to a Tertiary Care Hospital in Pakistan. Study Design: Cross-sectional study.
Noman Ur Rehman, Zujaja Hina Haroon, Ahsan Hussain, Hoor Gulalai Kakakhem   +3 more
doaj   +1 more source

Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia

Frontiers in Genetics, 2013
Multilocus genotypes have been shown to be of relevance for using pharmacogenomic principles to individualize drug therapy. As it relates to thiopurine therapy, genetic polymorphisms of TPMT are strongly associated with the pharmacokinetics and clinical ...
Gabriele eStocco, Gabriele eStocco, Raffaella eFranca, Federico eVerzegnassi, Margherita eLondero, Margherita eLondero, Marco eRabusin, Giuliana eDecorti   +7 more
doaj   +1 more source

Diyarbakır yöresinde tiopurin S-metil transferaz enzim eksikliği ve TPMT*2, *3B ve *3C mutasyonlarının belirlenmesi

, 2015
Tiopurin S-metil transferaz (TPMT) enzimi, 6-mercaptopürin veya azatiopürin gibi tiopürin ilaçlarının metilasyonunu katalizleyen sitoplazmik bir enzimdir. TPMT aktivitesi polimorfiktir ve üç tip enzim aktivitesi gözlenir.
Gelen, Koray
core   +1 more source

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn’s Disease

Pharmacogenomics and Personalized Medicine, 2020
Changhee Ha,1 Eun Sil Kim,2 Yiyoung Kwon,2 Yon Ho Choe,2 Mi Jin Kim,2 Soo-Youn Lee1,3 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Pediatrics, Samsung ...
Ha C, Kim ES, Kwon Y, Choe YH, Kim MJ, Lee SY   +5 more
doaj  

Thiopurine S-Methyltransferase Assay by HPLC in Acute Lymphoblastic Leukemia Patients and a Healthy Iranian Population

Acta Medica Iranica, 2018
Thiopurine s-methyltransferase (TPMT) plays a key role in the metabolism of the drug; 6-MP in children with acute lymphoblastic leukemia (ALL). The wild-type TPMT*1 allele and mutant alleles are associated with normal and intermediate enzyme activity ...
Sima Mozafari, Nahid Einollahi, Elham Shahgholi, Safoura Vardasbi, Abolfazl Golestani   +4 more
doaj  

Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?

, 2010
Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine medications, including azathioprine and 6-mercaptopurine. Absent TPMT activity (i.e., in individuals homozygous for a variant TPMT allele) is associated with an increased risk of ...
Roberts, Chris, Newman, William G.; id_orcid, Higgs, Jenny E., Payne, Katherine; id_orcid   +3 more
core   +1 more source

A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease

Acta Medica Iranica, 2017
Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied.
Fariborz Bahrehmand, Amir Kiani, Asad Vaisi-Raygani, Homayoun Bashiri, Mehdi Zobeiri, Ali Moini, Tayebeh Pourmotabbed   +6 more
doaj  

Análisis de los polimorfismos génicos de Tiopurina S-Metiltransferasa (TPMT) en pacientes pediátricos mexicanos con cáncer

, 2017
La Tiopurina S-Metiltransferasa (TPMT) cataliza la S-metilación de tiopurinas como la 6-mercaptopurina, 6-tioguanina y azatioprina, llevando a su inactivación.
Moreno Guerrero, Silvia Selene, Dorantes Acosta, Elsa María, Ramírez Pacheco, Arturo, Medina Sanson, Aurora   +3 more
core