Results 41 to 50 of about 5,467 (204)

An Epidemiological Study of Thiopurinemethyltransferase Variants in a Croatian Inflammatory Bowel Disease Patient Cohort

Acta Clinica Croatica, 2016
Thiopurine S-methyltransferase (TPMT) is an enzyme that converts thiopurine drugs into inactive metabolites. Over 20 variant TPMT-encoding alleles, which cause reduced enzymatic activity, have been discovered so far.
Agata Ladić, Nada Božina, Vladimir Borzan, Marko Brinar, Boris Vucelić, Silvija Čuković-Čavka   +5 more
doaj   +1 more source

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study. [PDF]

PLoS ONE, 2018
Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations.
Arno C Hessels, Abraham Rutgers, Jan Stephan F Sanders, Coen A Stegeman   +3 more
doaj   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

In Vitro Protein Stability of Two Naturally Occurring Thiopurine S‑Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8

, 2017
Thiopurine S-methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism and inactivation of thiopurine substances administered as immunosuppressants in the treatment of malignancies and autoimmune diseases.
Mårtensson, Lars-Göran,, Patricia Wennerstrand, Annica Blissing, Lars-Göran Mårtensson, Blissing, Annica Theresia,, Wennerstrand, Patricia,   +5 more
core   +1 more source

[leuko]*[aza] product over time for TPMT genotypes and tertiles of TPMT activity.

, 2018
[leukocyte]*[azathioprine] product 3,6,9 and 12 months after switch to azathioprine. *PTPMT variant carrier; Normal = normal genotype (wildtype TPMT). Lower graph (4B): T1 = lowest tertile, T2 = middle tertile, T3 = highest tertile of TPMT activity.
Jan Stephan F. Sanders (5076785), Abraham Rutgers (3562520), Coen A. Stegeman (344870), Arno C. Hessels (5076782)   +3 more
core   +1 more source

Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia

The Turkish Journal of Pediatrics, 2018
In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia.
Dilara Fatma Akın, Deniz Aşlar-Öner, Emin Kürekçi, Nejat Akar   +3 more
doaj   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Polimorfismos del gen tiopurina S-metiltransferasa (TPMT) en pacientes pediátricos peruanos con leucemia linfoblástica aguda

Horizonte Médico
Objetivo: Identificar las frecuencias alélicas, genotípicas y los fenotipos probables de las variantes del gen tiopurina S-metiltransferasa (TPMT) en una cohorte de pacientes pediátricos con leucemia linfoblástica aguda (LLA) tipo B, atendidos en el ...
Kelly Franco-Bustamante, Julio A. Poterico, Francisco Sánchez-Pinto, Joselyne Talledo-Rodríguez, María C. Medina-Pflucker, Victoria Godoy-Vila, Gioconda Manassero-Morales   +6 more
doaj   +1 more source

Comparison of pharmacogenomic guidance in Australian prescribing resources and international pharmacogenomic guidelines

Internal Medicine Journal, EarlyView.
Abstract Background Pharmacogenomic‐guided medication management optimises drug therapy to enhance patient outcomes. Despite clinical utility, implementation in Australia remains limited, partly due to the lack of clear and consistent guidance. Aim This study evaluated the presence and consistency of pharmacogenomic testing indication categories and ...
Ruby Soueid, Jackson L. A. Thomas, Luke B. Hesson, Stephen Hughes, Sophie L. Stocker   +4 more
wiley   +1 more source

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source