Results 21 to 30 of about 10,795 (251)

Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers

Advances in Therapy, 2022
Thiopurine drugs are purine nucleoside analogues used for treatment of different immune-related conditions. To date, different studies highlighted the importance of thiopurine methyltransferase (TPMT) genotyping in patients who initiate treatment with ...
A. Casajús, P. Zubiaur, M. Méndez, Diana Campodónico, Antía Gómez, M. Navares-Gómez, Gonzalo Villapalos-García, Paula Soria-Chacartegui, J. Novalbos, M. Román, G. Mejía-Abril, D. Ochoa, F. Abad‐Santos   +12 more
semanticscholar   +1 more source

Characterization of Reference Materials for TPMT and NUDT15 - A GeT-RM Collaborative Project.

Journal of Molecular Diagnostics, 2022
Pharmacogenetic testing is increasingly provided by clinical and research laboratories; however, only a limited number of quality control and reference materials (RMs) are currently available for many of the TPMT and NUDT15 variants included in clinical ...
V. Pratt, Wendy Y. Wang, Erin C. Boone, U. Broeckel, Neal A. L. Cody, Lisa Edleman, A. Gaedigk, T. Lynnes, Elizabeth B. Medeiros, A. Moyer, M. Mitchell, S. Scott, P. Starostik, Amy J. Turner, L. Kalman   +14 more
semanticscholar   +1 more source

TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results

Clinical pharmacology and therapy, 2021
Azathioprine is used frequently to treat several inflammatory conditions. However, treatment is limited by adverse events—in particular, myelotoxicity.
A. Dickson, Laura L. Daniel, J. Zanussi, W. Dale Plummer, Wei-Qi Wei, Ge Liu, Tyler Reese, P. Anandi, K. Birdwell, V. Kawai, N. Cox, W. Dupont, A. Hung, Q. Feng, C. Stein, C. Chung   +15 more
semanticscholar   +1 more source

DNA methylation of the TPMT gene and azathioprine pharmacokinetics in children with very early onset inflammatory bowel disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
BACKGROUND Thiopurine methyltransferase (TPMT) is a crucial enzyme for azathioprine biotransformation and its activity is higher in very early onset inflammatory bowel disease (VEO-IBD) patients than in adolescents with IBD (aIBD).
Davide Selvestrel, G. Stocco, M. Aloi, S. Arrigo, S. Cardile, E. Cecchin, M. Congia, Debora Curci, S. Gatti, F. Graziano, C. Langefeld, M. Lucafò, S. Martelossi, M. Martinelli, Sofia Pagarin, L. Scarallo, E. Stacul, C. Strisciuglio, S. Thompson, G. Zuin, G. Decorti, M. Bramuzzo   +21 more
semanticscholar   +1 more source

Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure. [PDF]

PLoS ONE, 2011
Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and ...
Amira Hosni-Ahmed, Joseph D Barnes, Jim Wan, Terreia S Jones   +3 more
doaj   +1 more source

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population [PDF]

Libyan Journal of Medicine, 2015
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene.
Hamza Ben Zeglam, Abdrazak Benhamer, Adel Aboud, Haitem Rtemi, Meftah Mattardi, Saleh Suleiman Saleh, Abdullah Bashein, Nabil Enattah   +7 more
doaj   +1 more source

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis

Scientific Reports, 2021
This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). A total of 113 Chinese patients with
Qiang Miao, Lin Yan, Yanhong Zhou, Yi Li, Yuangao Zou, Lanlan Wang, Yang-juan Bai, Junlong Zhang   +7 more
semanticscholar   +1 more source

TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia

Journal of Personalized Medicine, 2021
The response to 6-mercaptopurine (6-MP) can be altered by genetic polymorphisms in genes encoding drug-metabolizing enzymes and drug transporters.
T. Jantararoungtong, S. Wiwattanakul, Rawiporn Tiyasirichokchai, Santirhat Prommas, Rattanaporn Sukprasong, N. Koomdee, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, S. Pakakasama, U. Anurathapan, S. Hongeng, C. Sukasem   +12 more
semanticscholar   +1 more source

Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2020
6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism.
Gabriela Burgueño-Rodríguez, Yessika Méndez, Natalia Olano, Agustín Dabezies, Bernardo Bertoni, Jorge Souto, Luis Castillo, Julio da Luz, Ana María Soler   +8 more
doaj   +1 more source

Scientometric mapping as a strategic intelligence tool for the governance of emerging technologies [PDF]

, 2014
How can scientometric mapping function as a tool of ’strategic intelligence’ to aid the governance of emerging technologies? The present paper aims to address this question by focusing on a set of recently developed scientometric techniques, namely ...
Hopkins, Michael, Leydersdorff, Loet, Rafols, Ismael, Rotolo, Daniele   +3 more
core   +2 more sources