Results 21 to 30 of about 5,467 (204)

Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease [PDF]

The Saudi Journal of Gastroenterology
Background: Azathioprine, a common inflammatory bowel disease (IBD) treatment, carries a myelosuppression risk, particularly leukopenia. Thiopurine methyltransferase (TPMT) genotyping can predict azathioprine-induced leukopenia (AIL), but data on TPMT ...
Yaser K. Meeralam, Adnan. B. Al-Zanbagi, Mona Al Saedi, Mohammed Sulaimani, Abdulrahman Basfar, Wafi Almutawa, Sayeda H. Albelewi, Mohammed K. Shariff   +7 more
doaj   +2 more sources

Thiopurine methyltransferase phenotyping and genotyping in clinical practice preferred access arrangement [PDF]

, 2010
Thiopurine methyltransferase (TPMT) metabolises the widely prescribed thiopurine drugs. The activity of this enzyme varies between individuals and this can influence treatment success.
Graham, Valerie
core   +7 more sources

Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. [PDF]

PLoS ONE, 2015
Thiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs).
Yue-Ping Liu, Hai-Yan Wu, Xiang Yang, Han-Qing Xu, Yong-Chuan Li, Da-Chuan Shi, Jun-Fu Huang, Qing Huang, Wei-Ling Fu   +8 more
doaj   +1 more source

Pharmacogenomic tests in Oncology - finding the right dose

Brazilian Journal of Oncology, 2021
A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA).
Jeziel Basso, Gilberto Schwartsmann
doaj   +1 more source

Implementation of TPMT testing [PDF]

British Journal of Clinical Pharmacology, 2014
The activity of the enzyme thiopurine methyltransferase (TPMT) is regulated by a common genetic polymorphism. One in 300 individuals lack enzyme activity and 11% are heterozygous for a variant low activity allele and have an intermediate activity. The thiopurine drugs azathioprine, mercaptopurine and thioguanine are substrates for TPMT; these drugs ...
openaire   +2 more sources

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2014
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to
Vijay Gandhi Linga, Dorra Babu Patchva, Krishna Mohan Mallavarapu Venkata Tulasi, Krishnamani Iyer Kalpathi, Ashok Pillai, Sadashivudu Gundeti, Senthil J Rajappa, Raghunadharao Digumarti   +7 more
doaj   +1 more source

Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants [PDF]

Journal of Medical Biochemistry, 2010
Thiopurine S-methyltransferase (TPMT: EC 2.1.1.67) is an enzyme that metabolizes immunosuppressive thiopurine medications, used in the treatment of autoimmune diseases, cancer and in transplantation medicine.
Pavlović Sonja, Zukić Branka
doaj  

Analysis of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation [PDF]

Терапевтический архив, 2020
Aim. To study the peculiarities of carrying clinically significant allelic variants of TPMT and DPYD genes associated with the response to drug therapy in cancer practice among 9 ethnic groups of the Russian Federation. Materials and methods.
K. B. Mirzaev, D. S. Fedorinov, K. A. Akmalova, Sh. P. Abdullaev, A. A. Kachanova, Zh. A. Sozaeva, E. A. Grishina, G. N. Shuev, E. Yu. Kitaeva, V. V. Shprakh, S. Sh. Suleymanov, L. Z. Bolieva, M. S-H. Sozaeva, S. M. Zhuchkova, N. E. Gimaldinova, E. E. Sidukova, I. S. Burashnikova, A. A. Shikaleva, K. G. Zabudskaya, D. A. Sychev   +19 more
doaj   +1 more source

Azathioprine‐induced pancytopenia: A case report

Rheumatology & Autoimmunity, 2022
Azathioprine (AZA) is commonly used as immunosuppressive therapy for autoimmune diseases, including systemic lupus erythematosus (SLE). Myelosuppression is a common side effect of AZA.
Keshav Raj Sigdel, Astha Thapa, Agnimshwor Dahal, Ramchandra Panthi, Krishan Adhikari, Pradeep Shrestha, Mipsang Lama, Buddhi Poudyal, Buddha Basnyat   +8 more
doaj   +1 more source

Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT∗3 alleles [PDF]

, 2018
AIM: SNPs in the gene for TPMT exemplify one of the most successful translations of pharmacogenomics into clinical practice. This study explains the correlation between common SNPs and variable number of tandem repeats (VNTR) in promoter of the gene ...
Urbančič, Dunja, Šmid, Alenka, Decorti, Giuliana, Karas Kuželički, Nataša, Stocco, Gabriele, Mlinarič-Raščan, Irena   +5 more
core   +1 more source