Results 1 to 10 of about 6,220 (214)

Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine‐Induced Myelosuppression in Australia: A Budget Impact Analysis [PDF]

Clinical and Translational Science
Testing thiopurine methyltransferase (TPMT) enzyme activity or genotype prior to thiopurine prescribing is recommended to reduce the risk of moderate to severe—and potentially fatal—myelosuppression in poor or intermediate TPMT metabolizers. Despite this,
Bella D. Ianni, Mohammad Afshar Ali, Chin Hang Yiu, Edwin C. K. Tan, Christine Y. Lu   +4 more
doaj   +3 more sources

Nomenclature for alleles of the thiopurine methyltransferase gene. [PDF]

Pharmacogenet Genomics, 2013
The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice.
Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA.   +16 more
europepmc   +4 more sources

The Utility of Thiopurine Methyltransferase Enzyme Testing in Inflammatory Bowel Disease [PDF]

Canadian Journal of Gastroenterology, 2013
OBJECTIVE: To assess the levels of red blood cell thiopurine methyltransferase (TPMT) in subjects with inflammatory bowel disease (IBD) and to determine how these levels impacted thiopurine dosing and leukopenia over the first six months of therapy.
Laura Chisick, Curtis Oleschuk, Charles N Bernstein   +2 more
doaj   +2 more sources

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy [PDF]

Medical Sciences
The management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis, Kusnandar Anggadiredja, Aluicia Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli   +5 more
doaj   +2 more sources

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2014
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to
Vijay Gandhi Linga, Dorra Babu Patchva, Krishna Mohan Mallavarapu Venkata Tulasi, Krishnamani Iyer Kalpathi, Ashok Pillai, Sadashivudu Gundeti, Senthil J Rajappa, Raghunadharao Digumarti   +7 more
doaj   +2 more sources

Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]

European Journal of Clinical Pharmacology, 2018
Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M., Kullak-Ublick, G., Rammert, C., Rentsch, K., von Eckardstein, A., Wusk, Barbara   +5 more
core   +4 more sources

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease. [PDF]

Crohns Colitis 360, 2020
El-Matary W.
europepmc   +4 more sources

Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance [PDF]

Clinical Proteomics, 2011
Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics.
Wu Alan HB
doaj   +4 more sources

PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

Life Science Alliance, 2023
This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Giulia Zudeh, Raffaella Franca, Marianna Lucafò, Erik J Bonten, Matteo Bramuzzo, Riccardo Sgarra, Cristina Lagatolla, Martina Franzin, William E Evans, Giuliana Decorti, Gabriele Stocco   +10 more
doaj   +1 more source

Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review [PDF]

Precision and Future Medicine, 2021
The development of treatment options has revolutionized the prognosis of inflammatory bowel disease (IBD). However, a particular group of patients still experience therapeutic failure or drug side effects.
Ji Young Chang, Jae Hee Cheon
doaj   +1 more source