Results 21 to 30 of about 6,220 (214)

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Azathioprine‐induced pancytopenia: A case report

Rheumatology & Autoimmunity, 2022
Azathioprine (AZA) is commonly used as immunosuppressive therapy for autoimmune diseases, including systemic lupus erythematosus (SLE). Myelosuppression is a common side effect of AZA.
Keshav Raj Sigdel, Astha Thapa, Agnimshwor Dahal, Ramchandra Panthi, Krishan Adhikari, Pradeep Shrestha, Mipsang Lama, Buddhi Poudyal, Buddha Basnyat   +8 more
doaj   +1 more source

LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

Frontiers in Pharmacology, 2022
Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in ...
Amol O. Bajaj, Mark M. Kushnir, Mark M. Kushnir, Erik Kish-Trier, Rachel N. Law, Lauren M. Zuromski, Alejandro R. Molinelli, Gwendolyn A. McMillin, Gwendolyn A. McMillin, Kamisha L. Johnson-Davis, Kamisha L. Johnson-Davis   +10 more
doaj   +1 more source

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml, A.A. van Bodegraven, Al Hadithy AF, Artlich A, Bean RHD, Buffet C, C.J.J. Mulder, Carter MJ, Daniel F, De Boer N, de Boer NK, de Boer NK, de Jong D, Derijks LJ, Dervieux T, Dubinsky MC, Ferlitsch A, Fonseca V, Gane E, Gearry RB, H. Vogelsang, Haboubi NY, Herrlinger KR, Herrlinger KR, Herrlinger KR, J. Seiderer, Jones MC, K.R. Herrlinger, Katzka DA, Lilleyman JS, M. Lukas, M. Schwab, Marinaki AM, McBride KL, N.K.H. de Boer, Naber AH, P. Knoflach, Russmann S, Rutgeerts P, S. Almer, S.W. van der Merwe, Sandborn W, Schaeffeler E, Seiderer J, Shastri S, T. Ochsenkühn, Teml A, Teml A, Teml A, Tiede I, van Dieren JM, W. Petritsch, W. Reinisch   +52 more
core   +1 more source

Thiopurine methyltransferase screening before azathioprine therapy [PDF]

British Journal of Ophthalmology, 2006
Azathioprine is used to treat various inflammatory eye conditions such as uveitis and dysthyroid orbitopathy. Despite good overall clinical response rates, particularly when used as steroid sparing agent, adverse effects such as severe myelosuppression can lead to early withdrawal in approximately a quarter of patients.1,2 Thiopurine methyltransferase
V, Gauba, M, Saldanha, C, Vize, G M, Saleh   +3 more
openaire   +2 more sources

A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population

BMC Research Notes, 2022
Objective The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S ...
Kok-Siong Poon, Izz Irfan B. Imran, Silvester Kheng-Han Chew, Patrice Tan, Karen Mei-Ling Tan   +4 more
doaj   +1 more source

Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure. [PDF]

PLoS ONE, 2011
Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and ...
Amira Hosni-Ahmed, Joseph D Barnes, Jim Wan, Terreia S Jones   +3 more
doaj   +1 more source

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values

BMC Research Notes, 2018
Objectives This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use.
Ayorinde Adehin, Oluseye O. Bolaji
doaj   +1 more source

TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned

Frontiers in Pharmacology, 2022
Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs.
Liuh Ling Goh, Chia Wei Lim, Khai Pang Leong, Khai Pang Leong, Kiat Hoe Ong, Kiat Hoe Ong   +5 more
doaj   +1 more source