Results 31 to 40 of about 6,220 (214)

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics. [PDF]

Br J Haematol, 2015
Lennard L, Cartwright CS, Wade R, Vora A.   +3 more
europepmc   +2 more sources

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]

, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A., Cartwright, C.S., Fridley, B.L., Jenkins, G., Lennard, L., Li, F., Livshits, A., Matimba, A., Scully, S., Wang, L., Weinshilboum, R.   +10 more
core   +1 more source

The Role of Laboratory Tests in Crohn's Disease

Clinical Medicine Insights: Gastroenterology, 2016
In the past, laboratory tests were considered of limited value in Crohn's disease (CD). In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since ...
Maria Cappello, Gaetano Cristian Morreale   +1 more
doaj   +1 more source

Association of TPMT (rs1800460) Gene Polymorphism with Childhood Acute Lymphoblastic Leukemia in a Population from Guilan, Iran [PDF]

Journal of Genetic Resources, 2020
Acute lymphoblastic leukemia (ALL) is a malignant transformation and proliferation of lymphoid progenitor cells in bone marrow and blood, which is mainly found in children.
Mohammad Hedayati, Hamidreza Vaziri, Bahram Darbandi, Adel Baghersalimi, Mohammadmahdi Jafarzadeh, Ali Salehzadeh   +5 more
doaj   +1 more source

Azathioprine Metabolite Measurements Are not Useful for Following Treatment of Autoimmune Hepatitis in Alaska Native and other Non-Caucasian People

Canadian Journal of Gastroenterology, 2011
BACKGROUND: In autoimmune hepatitis (AIH) patients treated with azathioprine, the utility of measuring thiopurine methyltransferase (TPMT) and azathioprine metabolites has been limited.
Elizabeth D Ferucci, Kathy J Hurlburt, Marlyn J Mayo, Stephen Livingston, Heike Deubner, James Gove, Julia Plotnik, Brian J McMahon   +7 more
doaj   +1 more source

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population

Frontiers in Medicine, 2022
Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with ...
Xin-Hui Khoo, Shin Yee Wong, Nik Razima Wan Ibrahim, Ruey Terng Ng, Kee Seang Chew, Way Seah Lee, Zhi Qin Wong, Raja Affend Raja Ali, Shahreedhan Shahrani, Alex Hwong-Ruey Leow, Ida Normiha Hilmi, Ida Normiha Hilmi   +11 more
doaj   +1 more source

Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature [PDF]

, 2016
Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs.
Aleksandra Kovacevic, Natasa Djordjevic, Nemanja Rancic, Neven Vavic, Viktorija Dragojevic-Simic, Zoran Segrt   +5 more
core   +2 more sources

Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

Pharmacology Research & Perspectives, 2021
Xanthine oxidase (XO) competes with thiopurine S‐methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6‐mercaptopurine (6‐MP) in vivo.
Liang Ding, Fang‐bin Zhang, Hui Liu, Xiang Gao, Hui‐chang Bi, Ling Huang, Xue‐ding Wang, Bai‐li Chen, Yu Zhang, Chuanzhu Lv, Pin‐jin Hu, Min Huang   +11 more
doaj   +1 more source

Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease

Frontiers in Pharmacology, 2022
Despite the growing number of new drugs approved for the treatment of inflammatory bowel disease (IBD), the long-term clinical use of thiopurine therapy and the well-known properties of conventional drugs including azathioprine have made their place in ...
Slavica Lazarević, Maja Đanic, Hani Al-Salami, Armin Mooranian, Armin Mooranian, Momir Mikov   +5 more
doaj   +1 more source