Results 61 to 70 of about 1,959 (184)

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

Frontiers in Pharmacology, 2023
Azathioprine is clinically used as an immunosuppressant for treating autoimmune diseases. However it has narrow therapeutic indices due to frequent myelosuppression.
Juan Gu, Yupei Lin, Yuhe Wang
doaj   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

ال طفرة جينة NUDT15 R139C تزيد من خطورة تطور سمية محرضة بمركبات mercaptopurine عند مريضة سورية: تقرير حالة

مجلة جامعة دمشق للعلوم الطبية, 2022
خلفية البحث وهدفه: يعد دواء المركابتوبورين mercaptopurine (6MP) حجر الأساس في علاج مرضى الابيضاض اللمفاوي الحاد ولاسيما في مرحلة الصيانة. إن الهدف من عرض هذه الحالة هو إيضاح أسباب تطور تثبيط نقوي شديد عند مريضة مشخص لها ابيضاض لمفاوي حاد ولاسيما ...
محمد محمد, ماهر سيفو
doaj  

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

BMC Cancer, 2018
Background 6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients.
Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou, Yong Han   +6 more
doaj   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2364-2376, July 2026.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

NUDT15 변이 유전자형을 가진 급성림프모구백혈병 환자에서 치료 표지자로서 DNA-치오구아닌 뉴클레오티드의 이용 [PDF]

, 2021
학위논문 (박사) -- 서울대학교 대학원 : 의과대학 의학과, 2021. 2. 신희영.Background Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses.
주희영
core  

Seronegative Morvan Syndrome Presenting With Agrypnia Excitata and Peripheral Nerve Hyperexcitability: A Phenotype‐Supported Diagnostic and Therapeutic Approach in a Resource‐Limited Setting

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT We report a 63‐year‐old Palestinian man with seronegative Morvan syndrome presenting with the complete clinical triad: continuous neuromyotonia with visible myokymia, severe insomnia consistent with agrypnia excitata phenotype (2–3 h/night; Insomnia Severity Index [ISI] 24/28, validated Arabic version), tachycardia (118 bpm), profuse ...
Hatem Mousa Taha, Khaled Hatem Taha
wiley   +1 more source

The العلاقة بين التعدد الشكلي لجينة NUDT15 ذات الرقم ( rs116855232 ) والسمية النقوية المحرضة بمركبات البورين Mercaptopurine عند المرضى السوريين المشخص لديهم ابيضاض لمفاوي حاد

مجلة جامعة دمشق للعلوم الطبية, 2021
Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj  

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis

Scientific Reports, 2021
This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). A total of 113 Chinese patients with
Qiang Miao, Lin Yan, Yanhong Zhou, Yi Li, Yuangao Zou, Lanlan Wang, Yangjuan Bai, Junlong Zhang   +7 more
doaj   +1 more source

Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix, Anaïs Maillat, Eva Choong, Chantal Csajka, Monia Guidi, Francesco Ceppi   +5 more
wiley   +1 more source