Results 61 to 70 of about 2,479 (192)

Pharmacogenomic tests of oncology drugs at Instituto Nacional de Câncer (INCA)

Brazilian Journal of Oncology, 2021
The implementation, current status and future perspectives of the pharmacogenetics/genomics (PGx) testing program developed at Instituto Nacional de Cancer (INCA) are presented. Initial selection of drug-gene pairs for PGx testing was based on clinically-
Guilherme Suarez-Kurtz
doaj   +1 more source

Etiology and risk factors of febrile neutropenia in children during cancer treatment [PDF]

, 2020
Side effects due to chemotherapy is still a major issue during cancer treatment. Febrile neutropenia and associated microbiological defined infections (MDIs) are dreaded complications, and still a cause of death during pediatric cancer treatment.
Wahlund, Martina
core   +1 more source

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

BMC Gastroenterology, 2021
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively.
Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma   +9 more
doaj   +1 more source

NUDT15 변이 유전자형을 가진 급성림프모구백혈병 환자에서 치료 표지자로서 DNA-치오구아닌 뉴클레오티드의 이용 [PDF]

, 2021
학위논문 (박사) -- 서울대학교 대학원 : 의과대학 의학과, 2021. 2. 신희영.Background Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses.
주희영
core  

Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Clinical and Translational Science, 2023
The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on
Kelsey J. Cook, Victoria Grusauskas, Lucy Gloe, Benjamin Q. Duong, Renee C. Gresh, E. Anders Kolb, Manisha Bansal, Allison S. Bechtel, Ramamoorthy Nagasubramanian, Susan M. Kirwin, Kathryn V. Blake, Nathan D. Seligson   +11 more
doaj   +1 more source

Association of NUDT15*3 and FPGS 2572C>

Genes, 2020
Genetic variants influencing the pharmacokinetics and/or pharmacodynamics of the chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often contribute to the occurrence of treatment related toxicity (TRT). In this study, we explored the association of candidate genetic variants with early hematological TRT (grade 3 ...
Kodidela, Sunitha, Dorababu, Patchava, Thakkar, Dimpal N, Dubashi, Biswajit, Sundaram, Rajan, Muralidharan, Niveditha, Nidanapu, Ravi Prasad, Aribandi, Anil, Pradhan, Suresh Chandra, Uppugunduri, Chakradhara Rao Satyanarayana   +9 more
openaire   +1 more source

Decoding genetic divergence: TPMT and NUDT15 polymorphisms in north India mirror Caucasian ancestry. [PDF]

Intest Res
Singh A, Pandita RM, Goyal MK, Dhillon BK, Midha V, Sood A.   +5 more
europepmc   +3 more sources

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

Intestinal Research, 2017
Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine.
Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura   +13 more
doaj   +1 more source

Impact of mercaptopurine metabolites on disease outcome in the AIEOP-BFM 2009 protocol for acute lymphoblastic leukemia [PDF]

, 2023
: In the maintenance phase of AIEOP-BFM acute lymphoblastic leukemia (ALL) 2009 protocol, mercaptopurine (MP) is given at the planned dose of 50 mg/m2/day; however, dose adjustments are routinely performed to target patients' white blood cells to the ...
Bertorello, Nicoletta, Bettini, Laura Rachele, Colombini, Antonella, Decorti, Giuliana, Fagioli, Franca, Franca, Raffaella, Girardi, Katia, Kiren, Valentina, Locatelli, Franco, Quarello, Paola, Rabusin, Marco, Rizzari, Carmelo, Silvestri, Daniela, Stocco, Gabriele, Tessitore, Antimo, Valsecchi, Maria Grazia, Vinti, Luciana   +16 more
core   +1 more source