Results 81 to 90 of about 1,959 (184)

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

Journal of Translational Medicine, 2020
Background NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL).
Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im, Ju Han Kim   +11 more
doaj   +1 more source

Investigation of NUDT15 Allele Frequency in a Group of Iranian Population

Iranian journal of diabetes and metabolism
Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacyand safety of medications by studying the association between germline genetic variations and drug responses. Thepresent cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranianpopulation to ...
Negar Sarhangi, Mandana Hasanzad, Fatemeh Rouhollah, Shekoufeh Nikfa, Farshad Sharifi, Negar Niknam   +5 more
openaire   +1 more source

Clinical Actionability of the NUDT15 * 4 (p. R139H ) Allele and Its Association With Hispanic Ethnicity

International audienceNudix hydrolase 15 (NUDT15) deficiency is strongly associated with thiopurine‐induced myelosuppression. Currently, testing for NUDT15 deficiency is based on the genotyping of the most frequent and clinically characterized no ...
Hoshitsuki, Keito, Caudle, Kelly, Nguyen, Jenny Q., Karol, Seth E., Pui, Ching‐hon, Bhojwani, Deepa, Yang, Wenjian, Antillon-Klussmann, Federico, Crews, Kristine R., Haidar, Cyrine E., Bhatia, Smita, Jeha, Sima, Karol, Seth, Yang, Jun, Relling, Mary V., Relling, Mary, Haidar, Cyrine, Pui, Ching-Hon, Yang, Jun J., Inaba, Hiroto, Antillon-Klussmann, Federico G., Caudle, Kelly E., Nguyen, Jenny, Crews, Kristine, Maillard, Maud   +24 more
core   +1 more source

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency

British Journal of Clinical Pharmacology
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity.
Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky   +3 more
openaire   +2 more sources

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines

The Dutch Pharmacogenetics Working Group (DPWG) describes gene-drug interactions to facilitate pharmacogenetic implementation in clinical practice. The current guideline describes the gene-drug interactions for TPMT, NUDT15 and thiopurines (azathioprine,
Touw, Daan J.; id_orcid, Deneer, Vera H. M., Rongen, Gerard A.P.J.M., van Schaik, Ron H. N., Buunk, Anne Marie, Coenen, Marieke J. H., Risselada, Arne, Coenen, Marieke J.H.; id_orcid, Coenen, Marieke J.H., Schaik, R.H.N. van, Guchelaar, Henk Jan, van Schaik, Ron H.N., de Boer-Veger, Nienke J., Swen, Jesse J., Buunk, A.M., Soree, Bianca, Soree, B., Nijenhuis, Marga, Guchelaar, Henk-Jan, Houwink, Elisa J.F., Touw, Daan J., Houwink, Elisa J. F., Rongen, G.A.P.J.M., Deneer, Vera H.M., Rongen, Gerard A. P. J. M., Guchelaar, H.J., van Westrhenen, Roos, Deneer, V.H.M., Boer-Veger, N.J. de, Coenen, M.J.H.   +29 more
core   +1 more source

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

, 2017
Key Points We identified 3 novel loss-of-function variants in NUDT15 linked to thiopurine intolerance. Our findings extended the importance of NUDT15 variation in thiopurine pharmacogenetics in diverse populations.
Ting-Nien Lin, Mary V. Relling, Takaya Moriyama, Allen Eng-Juh Yeoh, Shirley Kham, Yung-Li Yang, Ching-Hon Pui, Wenjian Yang, Jun J. Yang, Sima Jeha, William E. Evans, Dong-Tsamn Lin, Chih-Hsiang Yu, Chengcheng Liu, Hany Ariffin, Rina Nishii   +15 more
core   +1 more source

NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

Frontiers in Pharmacology, 2019
The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis.
Xiaoli Fan, Dandan Yin, Ruoting Men, Heng Xu, Li Yang   +4 more
doaj   +1 more source

An Ambiguous NUDT15 Signal in a Child with B-cell Acute Lymphoblastic Leukemia. [PDF]

Clin Chem
Sterner RM, Sherani F, DiGuardo MA, Greipp PT, Moyer AM.   +4 more
europepmc   +4 more sources

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

, 2018
Key Points We established a Nudt15 knockout mouse model with which to evaluate individualized thiopurine therapy. Preemptive NUDT15 genotype–guided thiopurine dosing can effectively prevent drug toxicity without compromising antileukemic ...
Katsuyoshi Koh, Ting-Nien Lin, Tomohiro Morio, Takaya Moriyama, Allen Eng-Juh Yeoh, Hidemi Toyoda, Matthias Schwab, Shirley Kham, Wenjian Yang, Masatoshi Takagi, Nan Jiang, Ute Hofmann, Chase C. Suiter, Karen R. Rabin, Jun J. Yang, Lie Li, Atsushi Manabe, Hiroki Hori, Kentaro Kihira, Laura J. Janke, Motohiro Kato, Rina Nishii   +21 more
core   +1 more source

Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease

World Journal of Gastroenterology, 2018
To observe gene polymorphisms of TPMT and NUDT15, and compare their predictive value for azathioprine (AZA)-induced leukopenia in inflammatory bowel disease (IBD).This study enrolled 219 patients diagnosed with IBD in Xiangya Hospital, Central South University, Changsha, China from February 2016 to November 2017.
Wang, Hong-Hui, He, Ying, Wang, Hong-Xian, Liao, Cheng-Ling, Peng, Yu, Tao, Li-Jian, Zhang, Wei, Yang, Hui-Xiang   +7 more
openaire   +2 more sources