Results 91 to 100 of about 1,959 (184)

NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Aswin Anand Pai, Ajith Mohan, Esther Sathya Bama Benjamin, Raveen Stephen Stallon Illangeswaran, Infencia Xavier Raj, Nancy Beryl Janet, Arun Kumar Arunachalam, ML Kavitha, Uday Kulkarni, Anup J Devasia, NA Fouzia, Aby Abraham, Alok Srivastava, Biju ...
Pai AA, Mohan A, Benjamin ESB, Illangeswaran RSS, Xavier Raj I, Janet NB, Arunachalam AK, Kavitha ML, Kulkarni U, Devasia AJ, Fouzia NA, Abraham A, Srivastava A, George B, Mathews V, Korula A, Balasubramanian P   +16 more
doaj  

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines

The Dutch Pharmacogenetics Working Group (DPWG) describes gene-drug interactions to facilitate pharmacogenetic implementation in clinical practice. The current guideline describes the gene-drug interactions for TPMT, NUDT15 and thiopurines (azathioprine,
Nijenhuis, Marga, Rongen, Gerard A.P.J.M., Houwink, Elisa J.F., Buunk, Anne Marie, Touw, Daan J., Risselada, Arne, Apotheek Klinische Farmacie, Coenen, Marieke J.H., Guchelaar, Henk Jan, Deneer, Vera H.M., van Schaik, Ron H.N., de Boer-Veger, Nienke J., van Westrhenen, Roos, Circulatory Health, Swen, Jesse J., Soree, Bianca   +15 more
core   +1 more source

NUDT15 variant and thiopurine-induced leukopenia in Hong Kong [PDF]

Hong Kong Medical Journal, 2016
Felix C K, Wong, Alex W K, Leung, Jeffrey S S, Kwok, Michael H M, Chan, C K, Li, Y P, Yuen   +5 more
openaire   +2 more sources

Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients

, 2018
Background: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy.
Wee Chian Lim, Sai Wei Chuah, Hang Hock Shim, Wai Fook Leong, Natalia Sutiman, Madeline Tjai, Chris San Choon Kong, Vinayak Nadiger, Webber Chan, Khoon Lin Ling, Yin Bun Cheung, Chiea Chuen Khor, Balram Chowbay, Sylvia Chen, Brian John Schwender   +14 more
core   +1 more source

Ethnic variability of pharmacogenetic TPMT and NUDT15 variants in Russian populations: Implications for personalized thiopurine therapy

Alʹmanah Kliničeskoj Mediciny
Background: Thiopurines, including azathioprine and 6-mercaptopurine, are widely used in the treatment of inflammatory and autoimmune diseases, as well as hematological malignancies; however, their use is limited by the risk of severe myelosuppression ...
Irina R. Gilyazova, Alexandra S. Karunas, Marina A. Bermisheva, Askar A. Akhmetshin, Alfia E. Pushkareva, Natalia V. Ekomasova, Murat A. Dzhaubermezov, Irina M. Khidiyatova, Elza K. Khusnutdinova   +8 more
doaj   +1 more source

Optimizing mercaptopurine therapy in indian pediatric ALL: The role of TPMT and NUDT15 genetic polymorphisms

Cancer Treatment and Research Communications
Objective: This review aims to present and assess the existing scientific evidence on various genetic mutations of thiopurine S-methyltransferase (TPMT) and nucleoside diphosphate–linked moiety X-type motif 15 (NUDT15) and their potential implications in
Jayalakshmi Venugopal, Shalini Sivadasan, Rajasekaran Aiyalu   +2 more
doaj   +1 more source

Pharmacogene Variation Consortium Gene Introduction: NUDT15 [PDF]

Clinical Pharmacology & Therapeutics, 2018
Jun J. Yang, Michelle Whirl‐Carrillo, Stuart A. Scott, Amy J. Turner, Matthias Schwab, Yoichi Tanaka, Guilherme Suarez‐Kurtz, Elke Schaeffeler, Teri E. Klein, Neil A. Miller, Andrea Gaedigk   +10 more
openaire   +2 more sources

NUDT15, MRP4 and the development of precision medicine in Chile

Pharmacy & Pharmacology International Journal, 2022
Alonso De la Rivera Morales, Dominique Yanez Osorio, Carolina Salas Palma, Caroline Weinstein Oppenhimer   +3 more
openaire   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

NUDT15Genotyping in Thiopurine Drug Therapy

Laboratory Medicine Online, 2022
Jong Kwon Lee, Rihwa Choi, Soo-Youn Lee
openaire   +1 more source