Results 91 to 100 of about 2,479 (192)
مجلة جامعة دمشق للعلوم الطبية, 2021 Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj
مجلة جامعة دمشق للعلوم الطبية, 2022 خلفية البحث وهدفه: يعد دواء المركابتوبورين mercaptopurine (6MP) حجر الأساس في علاج مرضى الابيضاض اللمفاوي الحاد ولاسيما في مرحلة الصيانة. إن الهدف من عرض هذه الحالة هو إيضاح أسباب تطور تثبيط نقوي شديد عند مريضة مشخص لها ابيضاض لمفاوي حاد ولاسيما ...
محمد محمد, ماهر سيفو
doaj
The Nudix Hydrolase 15 (NUDT15) Gene Variants among Jordanian Arab Population [PDF]
Asian Pacific Journal of Cancer Prevention, 2019 Background: Nudix Hydrolase 15 gene (NUDT15) encodes nucleotide triphosphate diphosphatase which metabolizes the purine analog drugs, such as anticancer thiopurine and anti-gout allopurinol. Genetic variants on Nudix Hydrolase 15 gene (NUDT15) gene effects the drug’s hydrolyses and hence increases the susceptibility to drug-induced toxicity. The NUDT15
Jarrar, Yazun Bashir, Ghishan, Maria
openaire +2 more sources
Alopecia as an Early Clinical Marker for Azathioprine Induced Myelosuppression: A Case Report [PDF]
Azathioprine is a pro-drug and is metabolized by the TPMT enzyme in the body. In South Asians, Azathioprine is known to cause alopecia and bone marrow suppression in patients with TPMT enzyme deficiency.
Babu, Dr. M Suresh, , Professor +3 more
core +2 more sources
Ten years of Genome Medicine. [PDF]
, 2019 This year marks the 10th anniversary of Genome Medicine. The journal was launched to meet the need in the community for a platform to publish impactful and open science that advances basic and clinical research—using genetic, genomic, omic, and systems ...
Auffray, C +4 more
core +1 more source
Dermatology and Therapy, 2020 Introduction Azathioprine is a synthetic purine analogue derived from 6-mercaptopurine which acts by disrupting nucleic acid synthesis and interfering with T cell activation. It is effective in dermatology diseases related to the immune system.
Po-Wei Huang +2 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni +3 more
wiley +1 more source
Identification and expression analysis of peroxisome-targeted defence proteins mediating innate immunity in the model plant Arabidopsis thaliana [PDF]
, 2011 Master's thesis in Biological ChemistryPeroxisomes are single-membrane organelles that have oxidative metabolic functions. Peroxisomes carry out major functions such as lipid degradation, photorespiration and glyoxylate cycle. However, new functions have
Mwaanga, Chimuka
core
Frontiers in Pharmacology, 2019 Nudix Hydrolase 15 (NUDT15) and Thiopurine S-Methyltransferase (TPMT) are strong genetic determinants of thiopurine toxicity in pediatric acute lymphoblastic leukemia (ALL) patients.
Yoomi Park +11 more
doaj +1 more source
Journal of Translational Medicine, 2020 Background NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL).
Yoomi Park +11 more
doaj +1 more source