Results 71 to 80 of about 1,959 (184)

Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena   +3 more
doaj   +1 more source

Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Desta Seyoum Tadesse, Kalkidan Tekletsadik, Berhan Begashaw, Awgichew Shewasinad Yehualashet, Awol Mekonnen Ali, Kassahun Dires Ayenew   +5 more
wiley   +1 more source

Identifying Novel Pharmacogenetic Markers for Cancer Treatments: Exploiting Cancers Deficient in the Nucleotide Pool Sanitizing Hydrolases NUDT15 AND NUDT18 [PDF]

, 2022
The NUDIX hydrolases are a super family of enzymes with purported enzymatic activities of nucleotide hydrolases. The activity of the founding member, NUDT1 (also known as MTH1) is established to be a nucleotide hydrolase for d-8-oxoGTP, which is a ...
Massey, Jacob Chandler
core   +1 more source

Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study

Dermatology and Therapy, 2020
Introduction Azathioprine is a synthetic purine analogue derived from 6-mercaptopurine which acts by disrupting nucleic acid synthesis and interfering with T cell activation. It is effective in dermatology diseases related to the immune system.
Po-Wei Huang, Yu-Hsian Tseng, Tsen-Fang Tsai   +2 more
doaj   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Adalimumab‐responsive Monogenic Inflammatory Bowel Disease With Pseudopolyposis Characteristic of TGFBR2 Variant in Loeys‐Dietz Syndrome

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder caused by pathogenic variants in TGFBR1 or TGFBR2. It is characterized by vascular fragility, skeletal abnormalities, and predisposition to allergic and inflammatory conditions, including monogenic inflammatory bowel disease (IBD).
Tomomitsu Sado, Satoshi Ukai, Shingo Kurasawa, Yosuke Kono, Norio Hasuda, Mai Iwaya, Takaya Nakane, Tomomi Yamaguchi, Tomoki Kosho, Yoshiko Nakayama   +9 more
wiley   +1 more source

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia

, 2017
Thiopurines [e.g. mercaptopurine (MP)] are widely used as chemotherapeutic agents in the treatment of pediatric acute lymphoblastic leukemia with dose-limiting hematopoietic toxicity.
Kihira, Kentaro, Ting-Nien Lin, Toyoda, Hidemi, Moriyama, Takaya, Takaya Moriyama, Manabe, Atsushi, Nishii, Rina, Nersting Jacob, Jun J. Yang, Atsushi Manabe, Hiroki Hori, Lin, Ting Nien, Motohiro Kato, Rina Nishii, Katsuyoshi Koh, Koh, Katsuyoshi, Kato, Motohiro, Hiroto Inaba, Hidemi Toyoda, Kjeld Schmiegelow, Nersting, Jacob, Yang, Jun J., Inaba, Hiroto, Hori, Hiroki, Schmiegelow, Kjeld, Kentaro Kihira   +25 more
core   +1 more source

Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients

Frontiers in Pharmacology, 2019
Nudix Hydrolase 15 (NUDT15) and Thiopurine S-Methyltransferase (TPMT) are strong genetic determinants of thiopurine toxicity in pediatric acute lymphoblastic leukemia (ALL) patients.
Yoomi Park, Hyery Kim, Jung Yoon Choi, Jung Yoon Choi, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Ho Joon Im, Hyoung Jin Kang, Hyoung Jin Kang, Ju Han Kim, Ju Han Kim   +11 more
doaj   +1 more source

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2020
A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15.
Minyuan Cao, Minyuan Cao, Dandan Yin, Yun Qin, Fei Liao, Yali Su, Xuyang Xia, Ju Gao, Yiping Zhu, Wei Zhang, Yang Shu, Xiaoxi Lu   +11 more
doaj   +1 more source

Supervised learning of protein variant effects across large‐scale mutagenesis datasets

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The increasing availability of data from multiplexed assays of variant effects (MAVEs) enables supervised model training against large quantities of experimental data to learn sequence‐function relationships. Variant effect scores from MAVEs can, however, be influenced by the experimental method and library composition, resulting in experiment‐
Thea K. Schulze, Lasse M. Blaabjerg, Matteo Cagiada, Kresten Lindorff‐Larsen   +3 more
wiley   +1 more source