Results 101 to 110 of about 1,959 (184)

NUDT15 variants affect mercaptopurine tolerance in children [PDF]

Nature Reviews Clinical Oncology, 2015
openaire   +1 more source

Pre-treatment NUDT15 testing to inform thiopurine prescribing in patients with inflammatory bowel disease: an economic evaluation

Background Pre-treatment NUDT15 genotype is effective at identifying individuals likely to have severe thiopurine-induced myelosuppression (TIM).
Christopher Roberts, James R. Goodhand, Tariq Ahmad, Jaime L. Peters, Claire Bewshea, Nicholas A. Kennedy, Christopher Hyde   +6 more
core   +1 more source

Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease. [PDF]

Yonsei Med J
Boo EK, Yu J, Oh S, Cheon JH, Kim JH.
europepmc   +1 more source

Pharmacogenetic Predictors of Chemotherapy Treatment-Related Toxicities in Paediatric and Adolescent Acute Lymphoblastic Leukemia: A Systematic Review, Meta-Analysis and Literature-Based Candidate Prioritization. [PDF]

Pharmaceuticals (Basel)
Chenchula S, Srinivasamurthy SK, Vincent V, Thakkar H, Ganguly S, Kayal S, Keerthivasagam S, Ramamoorthy J, Sharma S, Murugadoss K, Singh A, Pushpam D, Mathaiyan J, Jolly B, Scaria V, Gloor Y, Baleydier F, Bakhshi S, Dubashi B, Ansari M, Uppugunduri CRS.   +20 more
europepmc   +1 more source

Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15

, 2016
Synthetic nucleobase- and nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against various forms of cancer.
Anna Hagenkort (18663970)
core  

Pharmacogenomic landscape in Thailand: Array-based profiling and EMR-linked medication exposure. [PDF]

PLoS One
Pasookhush P, Suta S, Pumeiam S, Mongkolsucharitkul P, Pinsawas B, Ophakas S, Mayurasakorn K.   +6 more
europepmc   +1 more source

Development of ganciclovir as an anti-human cytomegalovirus drug: historical perspectives and future prospects. [PDF]

J Gen Virol
Garcia Del Valle N, Strang BL.
europepmc   +1 more source

OP035 NUDT15 variants contribute to thiopurine-induced myelosuppression in European populations

, 2018
OP035 NUDT15 variants contribute to thiopurine-induced myelosuppression in European ...
H Sokol (13563943), J Koskela (13524691), M Voskuil (19228168), G Heap (19177945), Neel Heerasing (13087041), N Kennedy (11650153), J Harrison (7119110), T Ahmad (5785727), R Weersma (19228171), C Bewshea (5785718), G Walker (564399), M Weedon (19228174), J Goodhand (13657621), M Daly (7943327), D McGovern (13556320), P Hendy (13556296)   +15 more
core  

Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. [PDF]

Nat Commun
Marques AMC, Bauer LG, Nguyen TA, Orta AG, Venne JL, Cheng C, Balıkçı E, Liu Y, Tivon B, Kroupova A, Ciulli A, London N, Kubicek S, Huber KVM.   +13 more
europepmc   +1 more source

OC-046 Nudt15 variants contribute to thiopurine-induced myelosuppression in european populations

, 2017
OC-046 Nudt15 variants contribute to thiopurine-induced myelosuppression in european ...
PJ Hendy (19228165), T Ahmad (5785727), GA Heap (15786737), C Bewshea (5785718), GJ Walker (12222002), JW Harrison (15786734), NA Kennedy (12222005), Neel Heerasing (13087041), Goodhand (19239793), MN Weedon (7655270)   +9 more
core