Association between NUDT15 polymorphisms and thiopurineinduced leukopenia in pediatric acute lymphoblastic leukemia patients: a systematized review [PDF]
聖路加国際大学修士(公衆衛生学 ...
AKASHI, Airi, 赤司, 藍理
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Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel +13 more
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Frontiers in Pharmacology, 2020 A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15.
Minyuan Cao +11 more
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Personalization of thiopurine therapy: Current recommendations and future perspectives
Acta PharmaceuticaDespite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja +3 more
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Impacto de la mutación homocigota en Nudix hidrolasa 15 sobre la mielosupresión con 6-mercaptopurina en una niña europea con leucemia linfoblástica aguda: A propósito de un caso [PDF]
, 2023 A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP).
García-Fumero, Ricardo +5 more
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Clinical and Translational Science, Volume 19, Issue 1, January 2026.ABSTRACT Clinical genomics and pharmacogenomics have largely remained separate fields, though some genetic variants have overlapping disease risk and drug implications. However, the extent of this overlap is not well studied. To explore this gap, we cross‐referenced genes from the American College of Medical Genetics Secondary Findings v3.2 list with ...
Josiah D. Allen +3 more
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PHARMACOGENOMICS IN THE EMIRATI POPULATION: APPLICATIONS IN CARDIOVASCULAR DISEASES AND ONCOLOGY [PDF]
, 2020 Pharmacogenetic variations contribute to interindividual differences in drug response. Advances in molecular techniques provided insights into interpopulation pharmacogenomic variations.
Al Mahairi, Zeina Nizar
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Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia [PDF]
, 2019 The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in
Abdullah, M +32 more
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A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family [PDF]
, 2017 The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear.
A Battle +67 more
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Pharmacogene Variation Consortium Gene Introduction:
Clinical Pharmacology & Therapeutics, 2018 Jun J. Yang +10 more
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