Results 11 to 20 of about 1,959 (184)
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir [PDF]
Nature Communications, 2021 Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al.Rina Nishii, Takanori Mizuno, Daniel Rehling, Colton Smith, Brandi L. Clark, Xujie Zhao, Scott A. Brown, Brandon Smart, Takaya Moriyama, Yuji Yamada, Tatsuo Ichinohe, Makoto Onizuka, Yoshiko Atsuta, Lei Yang, Wenjian Yang, Paul G. Thomas, Pål Stenmark, Motohiro Kato, Jun J. Yang +18 moredoaj +5 more sourcesDevelopment of a chemical probe against NUDT15 [PDF]
Nature Chemical Biology, 2020 The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for ...Pudelko, L., Rasti, A., Homan, Evert J,, Carter, Megan, Regmi, Shruti, Tobias Koolmeister, Homan, Evert J., Helleday, Thomas,, Si Min Zhang, Wiita, E., Knapp, S., Berglund, U.W., Bräutigam, L., Mikael Altun, Axelsson, H., Carter, M., Krämer, Andreas, Valerie, Nicholas C. K., Homan, Evert J, Ann-Sofie Jemth, Eshtad, Saeed, Andreas Krämer, Scobie, Martin, Page, Brent D. G., Schaller, Torsten, Axelsson, Hanna, Brent D. G. Page, Adam Throup, Lundbäck, T., Göttmann, Mona, Altun, Mikael, Thomas Helleday, Zhang, Si Min, Valerie, Nicholas C K, Valerie, Nicholas C K,, Wallner, O., Rudd, S.G., Linda Pudelko, Hanna Axelsson, Rudd, Sean G., Throup, Adam,, Jemth, Ann-Sofie, Rudd, Sean G,, Krämer, A., Lund University., Berglund, Ulrika Warpman,, Daniel Rehling, Armando Cázares-Körner, Loseva, Olga, Pudelko, Linda, Schaller, T., Throup, A., Olov Wallner, Desroses, Matthieu,, Hagenkort, Anna,, Helleday, Thomas, Stefan Knapp, Krimpenfort, R., Torsten Schaller, Sarno, Antonio,, Shruti Regmi, Eshtad, S., Throup, Adam, Lundbäck, Thomas, Krimpenfort, Rosa, Axelsson, Hanna,, Juliane Kutzner, Eshtad, Saeed,, Kutzner, Juliane, Desroses, Matthieu, Sarno, A., Jemth, Ann-Sofie,, Pudelko, Linda,, Cazares Korner, A., Bräutigam, Lars, Carter, Megan,, Berglund, Ulrika Warpman, Christina Kalderén, Page, B.D.G., Olga Loseva, Matthieu Desroses, Wallner, Olov,, Martin Scobie, Almlöf, Ingrid, Azita Rasti, Elisée Wiita, Bräutigam, Lars,, Page, Brent D G, Page, Brent D G,, Koolmeister, Tobias,, Zhang, Si Min,, Krämer, Andreas,, Nicholas C. K. Valerie, Scobie, Martin,, Mona Göttmann, Koolmeister, T., Valerie, N.C.K., Rehling, D., Wiita, Elisée, Kutzner, J., Lundbäck, Thomas,, Rosa Krimpenfort, Almlöf, I., Altun, M., Sean G. Rudd, Rudd, Sean G, Zhang, S.M., Stenmark, P., Göttmann, Mona,, Kalderén, Christina, Ulrika Warpman Berglund, Rasti, Azita,, Warpman Berglund, Ulrika, Kalderén, C., Kutzner, Juliane,, Hagenkort, A., Ingrid Almlöf, Scobie, M., Anna Hagenkort, Cázares-Körner, Armando,, Jemth, A.-S., Pål Stenmark, Kalderén, Christina,, Stenmark, Pål,, Helleday, T., Wiita, Elisée,, Wallner, Olov, Loseva, Olga,, Sarno, Antonio, Jemth, A.S., Almlöf, Ingrid,, Göttmann, M., Knapp, Stefan, Rehling, Daniel,, Cázares-Körner, A., Koolmeister, Tobias, Regmi, Shruti,, Lars Bräutigam, Evert J. Homan, Altun, Mikael,, Cázares-Körner, Armando, Loseva, O., Hagenkort, Anna, Homan, E.J., Rasti, Azita, Desroses, M., Antonio Sarno, Rehling, Daniel, Krimpenfort, Rosa,, Megan Carter, Stenmark, Pål, Thomas Lundbäck, Saeed Eshtad, Regmi, S. +153 morecore +5 more sourcesNUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity [PDF]
Nature Genetics, 2016 Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms.Kihira, Kentaro, Xujie Zhao, Takaya Moriyama, Edwynn Kean-Hui Chiew, Relling, Mary V, Manabe, Atsushi, Hofmann, Ute, William E Evans, Ute Hofmann, Keito Hoshitsuki, Yang, Jun J, Hiroki Hori, Lin, Ting-Nien, Deepa Bhojwani, Katsuyoshi Koh, Koh, Katsuyoshi, Najera, Cesar Rolando, Perez-Andreu, Virginia, Kato, Motohiro, Schmiegelow, K., Klussmann, Federico Antillon, Tomoya Isobe, Kjeld Schmiegelow, Yan Lu, Wenjian Yang, Komada, Yoshihiro, Shirley Kow-Yin Kham, Yoshihiro Komada, Zhiwei Chen, Inaba, Hiroto, Isobe, Tomoya, Robert McCorkle, Lu, Yan, Hori, Hiroki, Virginia Perez-Andreu, Kham, Shirley Kow-Yin, McCorkle, Robert, Chen, Zhiwei, Ting-Nien Lin, Hoshitsuki, Keito, Moriyama, Takaya, Allen E J Yeoh, Cynthia Jeffries, Jacob Nersting, Nishii, Rina, Zhao, Xujie, Bhojwani, Deepa, Chiew, Edwynn Kean-Hui, Atsushi Manabe, Schwab, Matthias, Yeoh, Allen E J, Yang, Wenjian, Mary V Relling, Motohiro Kato, Rina Nishii, Hiroto Inaba, Matthias Schwab, Jun J Yang, Federico Antillon Klussmann, Nersting, Jacob, Ching-Hon Pui, Pui, Ching-Hon, Evans, William E, Cesar Rolando Najera, Lie Li, Li, Lie, Jeffries, Cynthia, Kentaro Kihira +67 morecore +4 more sourcesCharacterization of Reference Materials for TPMT and NUDT15
The Journal of Molecular Diagnostics, 2022 Pharmacogenetic testing is increasingly provided by clinical and research laboratories; however, only a limited number of quality control and reference materials are currently available for many of the TPMT and NUDT15 variants included in clinical tests. Turner, Amy, Pratt, Victoria M., Victoria M. Pratt, Lisa V. Kalman, Mitchell, Matthew W., Ty C. Lynnes, Broeckel, Ulrich, Medeiros, Elizabeth B., Wang, Wendy Y., Neal Cody, Wendy Y. Wang, Ann M. Moyer, Erin C. Boone, Amy Turner, Starostik, Petr, Petr Starostik, Lynnes, Ty C., Andrea Gaedigk, Lisa Edelmann, Boone, Erin C., Ulrich Broeckel, Scott, Stuart A., Kalman, Lisa V., Matthew W. Mitchell, Moyer, Ann M., Stuart A. Scott, Edelmann, Lisa, Gaedigk , Andrea, Elizabeth B. Medeiros, Cody, Neal +29 morecore +3 more sourcesNUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities
Frontiers in Pediatrics, 2022 BackgroundThiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression.Fang Zhang, Gulbanur Amat, Yanjing Tang, Ru Chen, Xin Tian, Wenting Hu, Changcheng Chen, Shuhong Shen, Yangyang Xie +8 moredoaj +3 more sourcesNUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases
Intestinal Research, 2017 Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine.Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura +13 moredoaj +2 more sourcesGenetic profiling of NUDT15 in the Slovenian population
PharmacogenomicsDetermining variant TPMT alleles to predict patient response to thiopurine therapy represents one of the first successful implementations of pharmacogenomics in clinical practice.Prelog, Tomaž, Jazbec, Janez, Šmid, Alenka, Stollarova, Natalia, Kavčič, Marko, Karas Kuželički, Nataša, Vrevc Žlajpah, Jaka, Urbančič, Dunja, Mlinarič-Raščan, Irena +8 morecore +4 more sourcesNUDT15 hydrolyzes 6 thio deoxyGTP to mediate the anticancer efficacy of 6 thioguanine [PDF]
Cancer Research, 2016 Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics, their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention on the basis of Masuyer, G., Hagenkort, A., Homan, E., Masuyer, Geoffrey,, Herr, Patrick, Valerie, N.C., Homan, Evert, Helleday, Thomas, Sheppard, Nina G., Jemth, A.-S., Carter, M., Sheppard, N.G., Stenmark, Pål,, Helleday, T., Valerie, Nicholas C. K., Page, Brent D. G., Jemth, A.S., Bevc, L., Rehling, Daniel,, Herr, P., Rehling, D., Valerie, N.C.K., Jemth, Ann-Sofie, Stenmark, P., Hagenkort, Anna, Carter, Megan,, Page, B.D.G., Bevc, Luka, Page, B.D. +28 morecore +6 more sources
