Results 71 to 80 of about 63,671 (294)
Arthritis &Rheumatology, Accepted Article.Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia +4 more
wiley +1 more source
Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency
British Journal of Clinical Pharmacology, EarlyView.Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu +3 more
wiley +1 more source
Evaluating the Effect of Ginger Extract on Azathioprine-Induced Renal Failure in Mature Female Rats
Journal of Ardabil University of Medical Sciences, 2018 Background & objectives: Azathioprine is widely used for the treatment of autoimmune diseases. It has negative effects on the function of kidney.
Zahra Godarzian, Ebrahim Hosseini
doaj
Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia
American Journal of Perinatology Reports, 2013 An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells ...
Hidehiko Maruyama +4 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines.
Tanushree Haldar +11 more
wiley +1 more source
Acquired demyelinating disorders of central nervous system: A pediatric cohort
Annals of Indian Academy of Neurology, 2015 Objective : This is a retrospective chart review of consecutive children with acquired demyelinating disorders presenting to a north Indian tertiary care hospital over 4 years.
Sheffali Gulati +5 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
The Chemical Record, Volume 22, Issue 12, December 2022., 2022 Three generations of neutral and anionic water‐soluble palladium complexes act as versatile catalysts for the modification of unprotected halonucleosides. Abstract Modification of unprotected nucleosides has been attracting continuous interest, since these building blocks themselves and their phosphate‐upgraded corresponding nucleotides have shown a ...
José Luis Serrano
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source