AZD1775 And Anti-PD-1 Antibody Synergistically Sensitize Hepatoma to Radiotherapy [PDF]
Chinese Medical Journal. Background:. Radiation (IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment (TME). Wee1, a cell cycle regulator, can eliminate G2/M arrest by phosphorylating cyclin-dependent kinase 1 (CDK1 ...
Junxuan Yi
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Introduction to Single‐Cell Physiologically‐Based Pharmacokinetic (scPBPK) Models [PDF]
CPT: Pharmacometrics & Systems PharmacologyThe current investigation introduces single‐cell physiologically based pharmacokinetic (scPBPK) models to gain insight into drug disposition at the cellular scale.
Anshul Saini, James M. Gallo
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Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models [PDF]
npj Precision OncologyH3K27M diffuse midline gliomas (DMG) are characterized by p53 mutations and hypomethylation of MGMT, a DNA-repair enzyme, leading to resistance towards chemotherapeutic agents such as temozolomide (TMZ). As an alternative, we investigated the efficacy of
Bavani Subramaniam +13 more
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Wee1 Inhibitor AZD1775 Effectively Inhibits the Malignant Phenotypes of Esophageal Squamous Cell Carcinoma in Vitro and in Vivo [PDF]
Frontiers in Pharmacology, 2019 Esophageal squamous cell carcinoma (ESCC) is a common malignant diagnosed cancer with increasing incidence rate and few treatment options. As a specific small-molecule inhibitor of the Wee1 tyrosine kinase, AZD1775 has previously shown potent antitumor ...
Liang Chen, Chaojie Wang, Liang Chen
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Advanced Science, 2022 Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood.
Rourou Xiao, Ensong Guo, Yang Jin
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WEE1 inhibition delays resistance to CDK4/6 inhibitor and antiestrogen treatment in ER+ MCF7 cells [PDF]
npj Systems Biology and ApplicationsAlthough endocrine therapies and Cdk4/6 inhibitors have improved outcomes for patients with estrogen receptor positive (ER+ ) breast cancer, continuous application of these drugs often results in resistance.
Wei He +4 more
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WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2 [PDF]
Nature CommunicationsInhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between WEE1 small-molecule inhibitors and defects in mRNA translation, mediated by activation of the integrated
Jordan C. J. Wilson +20 more
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Anti-cancer drug sensitivity testing and preclinical evaluation of the anti-cancer potential of WEE1 inhibitor in triple-negative breast cancer patient-derived organoids and xenograft models [PDF]
Breast Cancer ResearchBackground Relevant surrogates that maintain the pathological and physiological properties of patient tumors are essential for guiding triple-negative breast cancer (TNBC) therapy.
Seungyeon Ryu +13 more
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GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer [PDF]
Cell ReportsSummary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity.
Alexandros P. Drainas +9 more
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Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities [PDF]
CellsCancer cell spheroids autonomously form in the ascites fluid and are considered a conduit for epithelial ovarian cancer metastasis within the peritoneal cavity. Spheroids are homotypic, avascular 3D structures that acquire resistance to anoikis to remain
Bart Kolendowski +4 more
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