Results 1 to 10 of about 10,965 (175)

BRCA1 Mutation-Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING-Associated Antitumor Immunity in Ovarian Cancer. [PDF]

Adv Sci (Weinh)
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Wang C, Yao M, Xie J, Wang D, Shi Y, Mao X, Lu C, Sun P.   +7 more
europepmc   +2 more sources

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression. [PDF]

Cancer Med
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Yan L, Liu S, Li Y, He Q, Long C, Tang N, Zhou Y.   +6 more
europepmc   +2 more sources

Targeting the DNA Damage Response in Cancer. [PDF]

MedComm (2020)
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Qiao Y, Kang B, Zhang J, Zhang R, Li J.
europepmc   +2 more sources

Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression [PDF]

Journal of Developmental Biology
Regulation of the cell cycle is critical for maintaining genomic integrity. Therefore, cells have adapted several mechanisms to ensure that cell cycle events occur in a precise order.
Shannon Pfeiffer, Lourds M. Fernando, Anna K. Allen, Aimee Jaramillo-Lambert   +3 more
doaj   +2 more sources

LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1 [PDF]

Signal Transduction and Targeted Therapy
Metabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets.
Hyeon-Ji Kim, Cheolhee Jeong, Sang-Heon Lee, Seungchan An, Gyu Hwan Hyun, Ga Young Lim, Ju-Yeon Kim, Junhyeong Lee, Min-Jung Park, Sung Won Kwon, Won Kim, Minsoo Noh, Yong-Hyun Han, Mi-Ock Lee   +13 more
doaj   +2 more sources

WEE1 Inhibition Enhances the Antitumor Immune Response to PD-L1 Blockade by the Concomitant Activation of STING and STAT1 Pathways in SCLC

Cell Reports, 2022
Summary: Small cell lung cancers (SCLCs) have high mutational burden but are relatively unresponsive to immune checkpoint blockade (ICB). Using SCLC models, we demonstrate that inhibition of WEE1, a G2/M checkpoint regulator induced by DNA damage ...
Charles Rudin, Joseph M Chan, Shweta S Chavan   +2 more
exaly   +3 more sources

WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer [PDF]

EMBO Molecular Medicine
Molecular therapies targeting the EGFR/MAPK pathway have improved outcomes in colorectal cancer (CRC), yet acquired resistance remains a major clinical challenge. Oncogenic signaling can activate stress response pathways that sustain tumor survival under
Kristi Buzo, Laura Bizzozero, Marilena Lentini, Alena Opattova, Beatriz Hernández-Suárez, Michael Torres, Giulia Chiabotto, Clelia Nisticò, Giada De Lazzari, Eugenia R Zanella, Gaia Grasso, Elisa Mariella, Erika Durinikova, Michael Linnebacher, Andrea Sartore-Bianchi, Salvatore Siena, Livio Trusolino, Alberto Bardelli, Sabrina Arena   +18 more
doaj   +2 more sources

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development. [PDF]

Cancer Sci
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Kamakura N, Jo M, Takahashi M, Hirota T.
europepmc   +2 more sources

Construction and expression of Wee1 recombinant protein in Escherichia coli strain BL21 (DE3)

Jurnal Ilmu Dasar, 2023
Wee1 is a gene encoding for protein kinase that is located in the nucleus and it plays an essential role in determining the timing of mitosis. Overexpression of Wee1 in rice is resulting in increased plant size.
Ladefa Primana Oktapan, Ardela Alief Maulani, Netty Ermawati, Bambang Sugiharto   +3 more
doaj   +1 more source

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +1 more source