Results 1 to 10 of about 13,336 (197)

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +2 more sources

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context-Dependent Therapeutic Vulnerability. [PDF]

Genes Chromosomes Cancer
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Li L, He B, Hao M, Liu Y, Song S, He R.
europepmc   +2 more sources

LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1 [PDF]

Signal Transduction and Targeted Therapy
Metabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets.
Hyeon-Ji Kim, Cheolhee Jeong, Sang-Heon Lee, Seungchan An, Gyu Hwan Hyun, Ga Young Lim, Ju-Yeon Kim, Junhyeong Lee, Min-Jung Park, Sung Won Kwon, Won Kim, Minsoo Noh, Yong-Hyun Han, Mi-Ock Lee   +13 more
doaj   +2 more sources

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development. [PDF]

Cancer Sci
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Kamakura N, Jo M, Takahashi M, Hirota T.
europepmc   +2 more sources

WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer [PDF]

EMBO Molecular Medicine
Molecular therapies targeting the EGFR/MAPK pathway have improved outcomes in colorectal cancer (CRC), yet acquired resistance remains a major clinical challenge. Oncogenic signaling can activate stress response pathways that sustain tumor survival under
Kristi Buzo, Laura Bizzozero, Marilena Lentini, Alena Opattova, Beatriz Hernández-Suárez, Michael Torres, Giulia Chiabotto, Clelia Nisticò, Giada De Lazzari, Eugenia R Zanella, Gaia Grasso, Elisa Mariella, Erika Durinikova, Michael Linnebacher, Andrea Sartore-Bianchi, Salvatore Siena, Livio Trusolino, Alberto Bardelli, Sabrina Arena   +18 more
doaj   +2 more sources

WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

Cell Reports, 2022
Summary: Small cell lung cancers (SCLCs) have high mutational burden but are relatively unresponsive to immune checkpoint blockade (ICB). Using SCLC models, we demonstrate that inhibition of WEE1, a G2/M checkpoint regulator induced by DNA damage ...
Charles Rüdin, Joseph Chan, Shweta Chavan   +2 more
exaly   +3 more sources

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies [PDF]

Advanced Science
ARID1A, a component of the SWI/SNF tumor suppressor complex, is frequently mutated in colorectal cancers (CRC). Here, it is found that CRC with ARID1A/TP53 concurrent mutations is highly sensitive to WEE1 inhibitors.
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
doaj   +2 more sources

Construction and expression of Wee1 recombinant protein in Escherichia coli strain BL21 (DE3)

Jurnal Ilmu Dasar, 2023
Wee1 is a gene encoding for protein kinase that is located in the nucleus and it plays an essential role in determining the timing of mitosis. Overexpression of Wee1 in rice is resulting in increased plant size.
Ladefa Primana Oktapan, Ardela Alief Maulani, Netty Ermawati, Bambang Sugiharto   +3 more
doaj   +1 more source

MicroRNA-dependent inhibition of WEE1 controls cancer stem-like characteristics and malignant behavior in ovarian cancer

Molecular Therapy: Nucleic Acids, 2022
Cancer stem-like cells (CSCs) have been suggested to be responsible for chemoresistance and tumor recurrence owing to their self-renewal capacity and differentiation potential. Although WEE1 is a strong candidate target for anticancer therapies, its role
Jin Gu Cho, Sung-wook Kim, Aram Lee, Ha-neul Jeong, Eunsik Yun, Jihea Choi, Su Jin Jeong, Woochul Chang, Sumin Oh, Kyung Hyun Yoo, Jung Bok Lee, Sukjoon Yoon, Myeong-Sok Lee, Jong Hoon Park, Min Hyung Jung, So-Woon Kim, Ki Hyung Kim, Dong Soo Suh, Kyung Un Choi, Jungmin Choi, Jongmin Kim, Byung Su Kwon   +21 more
doaj   +1 more source

Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma

Molecular Therapy: Oncolytics, 2023
Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC.
Md Obaidul Islam, Krishnapriya Thangaretnam, Heng Lu, Dunfa Peng, Mohammed Soutto, Wael El-Rifai, Silvia Giordano, Yuguang Ban, Xi Chen, Daniel Bilbao, Alejandro V. Villarino, Stephan Schürer, Peter J. Hosein, Zheng Chen   +13 more
doaj   +1 more source