Results 11 to 20 of about 13,336 (197)
WEE1 inhibition sensitizes osteosarcoma to radiotherapy [PDF]
BMC Cancer, 2011 Background The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surgery or have undergone an ...
Helder Marco N +6 more
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Cdc25 and Wee1: analogous opposites? [PDF]
Cell Division, 2007 Movement through the cell cycle is controlled by the temporally and spatially ordered activation of cyclin-dependent kinases paired with their respective cyclin binding partners.
Kornbluth Sally, Perry Jennifer A
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Identification of a novel Wee1 isoform
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005 We have identified a novel isoform of Wee1 kinase (Wee1i), which uses Met215 of Wee1 as its initiation codon. RT-PCR, Western blot, and in situ hybridization verified wee1i expression in mammalian cells, rat brain, and rat thymus. Recombinant and partially purified Wee1i from rat thymus displayed kinase activity comparable to or higher than Wee1. The N-
Yu, YP +10 more
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Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry [PDF]
Cell Division, 2010 The kinase Wee1 has been recognized for a quarter century as a key inhibitor of Cyclin dependent kinase 1 (Cdk1) and mitotic entry in eukaryotes. Nonetheless, Wee1 regulation is not well understood and its large amino-terminal regulatory domain (NRD) has
Enders Greg H
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Fission yeast Wee1 is required for stable kinetochore-microtubule attachment [PDF]
Open BiologyWee1 is a cell cycle regulator that phosphorylates Cdk1/Cdc2 and inhibits G2/M transition. Loss of Wee1 in fission yeast results in an early onset of mitosis.
Masahiro Takado +3 more
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Spatiotemporal regulations of Wee1 at the G2/M transition
Molecular Biology of the Cell, 2011 Wee1 is a protein kinase that negatively regulates mitotic entry in G2 phase by suppressing cyclin B–Cdc2 activity, but its spatiotemporal regulations remain to be elucidated. We observe the dynamic behavior of Wee1 in Schizosaccharomyces pombe cells and manipulate its localization and kinase activity to study its function.
Masuda, Hirohisa +4 more
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Cell Communication and Signaling, 2022 Background The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential role not only in the initiation and ...
Fanting Zeng +6 more
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Efficacy and Mechanism Evaluation, 2022 Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame.
Louise C Brown +12 more
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WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway
Reproductive Biology and Endocrinology, 2021 Background Endometriosis, the presence of active endometrial tissue outside the lining membrane of the uterine cavity, is a common disease in women of childbearing age.
Liya Shi +9 more
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Thoracic Cancer, 2023 Background DNA damage repair is a crucial mechanism highly related to therapy resistance for various therapeutic strategies. Our previous results have shown that the degree of drug resistance in small‐cell lung cancer (SCLC) cell lines was proportional ...
Xiaoliang Zhao, Xiaohua Wen, Bin Liu
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