Results 31 to 40 of about 10,965 (175)
Cell Death Discovery, 2022 The altered part of long non-coding RNA LINC00511 (LINC00511) is extensively discussed in malignancies. Finitely, the mechanism of LINC00511 in colon cancer (CC) development lacks thorough explorations.
Xiaowu Qian +6 more
doaj +1 more source
High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. [PDF]
PLoS ONE, 2012 Notoriously resistant malignant melanoma is one of the most increasing forms of cancer worldwide; there is thus a precarious need for new treatment options. The Wee1 kinase is a major regulator of the G(2)/M checkpoint, and halts the cell cycle by adding
Gry Irene Magnussen +5 more
doaj +1 more source
Wee1 kinase as a target for cancer therapy [PDF]
Cell Cycle, 2013 Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer.
Khanh, Do +2 more
openaire +2 more sources
Structural conservation of WEE1 and its role in cell cycle regulation in plants
Scientific Reports, 2021 The WEE1 kinase is ubiquitous in plant development and negatively regulates the cell cycle through phosphorylations. However, analogies with the control of the human cell cycle by tyrosine- (Tyr-) phosphorylation of cyclin-dependent kinases (CDKs) are ...
A. Détain +3 more
doaj +1 more source
Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1
Frontiers in Oncology, 2022 Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and chemotherapy.
Amirali B. Bukhari +2 more
doaj +1 more source
Advanced Science, EarlyView.Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou +17 more
wiley +1 more source
Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry
Cell Division, 2010 The kinase Wee1 has been recognized for a quarter century as a key inhibitor of Cyclin dependent kinase 1 (Cdk1) and mitotic entry in eukaryotes. Nonetheless, Wee1 regulation is not well understood and its large amino-terminal regulatory domain (NRD) has
Enders Greg H
doaj +1 more source
Discovery of potential WEE1 inhibitors via hybrid virtual screening
Frontiers in Pharmacology, 2023 G2/M cell cycle checkpoint protein WEE1 kinase is a promising target for inhibiting tumor growth. Although various WEE1 inhibitors have entered clinical investigations, their therapeutic efficacy and safety profile remain unsatisfactory.
Tingting Jin +10 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Identification of genomic biomarkers to predict the anticancer effects of indicated drugs is considered a promising strategy for the development of precision medicine. DNA endonuclease MUS81 plays a pivotal role in various biological processes
Chengguo Li +9 more
doaj +1 more source
Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1
The FEBS Journal, EarlyView.In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández +4 more
wiley +1 more source