Results 31 to 40 of about 13,336 (197)
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation and anaphase entry [PDF]
, 2012 Defects in DNA replication and chromosome condensation are common phenotypes in cancer cells. A link between replication and condensation has been established, but little is known about the role of checkpoints in monitoring chromosome condensation.
Campbell, S.D. +6 more
core +1 more source
ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
The Journal of Clinical Investigation, 2023 WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear.
Jie Li +16 more
doaj +1 more source
Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint [PDF]
, 2007 Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a transient cell cycle arrest that allows cells to repair DNA before proceeding into mitosis.
De Schutter, Kristof +24 more
core +1 more source
Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma
Frontiers in Pharmacology, 2018 WEE1 is a tyrosine kinase that regulates G2/M cell cycle checkpoint and frequently overexpressed in various tumors. However, the expression and clinical significance of WEE1 in human laryngeal squamous cell carcinoma (LSCC) are still unknown.
Meng-Ling Yuan +14 more
doaj +1 more source
Journal of Dental Sciences, 2022 Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation.
Yu-Hsueh Wu +3 more
doaj +1 more source
Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation [PDF]
, 2012 [EN]The activity of Cdk1–cyclin B1 mitotic complexes is regulated by the balance between the counteracting activities of Wee1/Myt1 kinases and Cdc25 phosphatases.
Sacristán Martín, María Paz +3 more
core +1 more source
WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia
Haematologica, 2020 T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors.
Juncheng Hu +14 more
doaj +1 more source
Cell Death Discovery, 2022 The altered part of long non-coding RNA LINC00511 (LINC00511) is extensively discussed in malignancies. Finitely, the mechanism of LINC00511 in colon cancer (CC) development lacks thorough explorations.
Xiaowu Qian +6 more
doaj +1 more source
A Wee1 checkpoint inhibits anaphase onset [PDF]
Journal of Cell Biology, 2013 Cdk1 drives both mitotic entry and the metaphase-to-anaphase transition. Past work has shown that Wee1 inhibition of Cdk1 blocks mitotic entry. Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation of the mitotic form of the anaphase-promoting complex/
Lianga, Noel +7 more
openaire +2 more sources
High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. [PDF]
PLoS ONE, 2012 Notoriously resistant malignant melanoma is one of the most increasing forms of cancer worldwide; there is thus a precarious need for new treatment options. The Wee1 kinase is a major regulator of the G(2)/M checkpoint, and halts the cell cycle by adding
Gry Irene Magnussen +5 more
doaj +1 more source