Results 41 to 50 of about 13,336 (197)
Structural conservation of WEE1 and its role in cell cycle regulation in plants
Scientific Reports, 2021 The WEE1 kinase is ubiquitous in plant development and negatively regulates the cell cycle through phosphorylations. However, analogies with the control of the human cell cycle by tyrosine- (Tyr-) phosphorylation of cyclin-dependent kinases (CDKs) are ...
A. Détain +3 more
doaj +1 more source
Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1
Frontiers in Oncology, 2022 Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and chemotherapy.
Amirali B. Bukhari +2 more
doaj +1 more source
Wee1 kinase as a target for cancer therapy [PDF]
Cell Cycle, 2013 Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer.
Khanh, Do +2 more
openaire +2 more sources
Casein kinase 1δ-dependent Wee1 protein degradation
, 2014 Eukaryotic mitotic entry is controlled by Cdk1, which is activated by the Cdc25 phosphatase and inhibited by Wee1 tyrosine kinase, a target of the ubiquitin proteasome pathway.
Ramachandran, Vimal +12 more
core +1 more source
Investigation into Sustainability of WEE1 Kinase in Plants
Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase.
Cook, Gemma S.
core +6 more sources
Journal of Experimental & Clinical Cancer Research, 2021 Background Identification of genomic biomarkers to predict the anticancer effects of indicated drugs is considered a promising strategy for the development of precision medicine. DNA endonuclease MUS81 plays a pivotal role in various biological processes
Chengguo Li +9 more
doaj +1 more source
Discovery of potential WEE1 inhibitors via hybrid virtual screening
Frontiers in Pharmacology, 2023 G2/M cell cycle checkpoint protein WEE1 kinase is a promising target for inhibiting tumor growth. Although various WEE1 inhibitors have entered clinical investigations, their therapeutic efficacy and safety profile remain unsatisfactory.
Tingting Jin +10 more
doaj +1 more source
Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes
Journal of Applied Polymer Science, EarlyView.Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis +1 more
wiley +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]
PLoS ONE, 2013 Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak +6 more
doaj +1 more source