Results 61 to 70 of about 13,336 (197)

MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

Journal of Hematology & Oncology, 2017
The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear.
Pei Li, Yang Yang, Hui Liu, An-Kui Yang, Jin-Ming Di, Guang-Mou Tan, Hai-Feng Wang, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei, Jia-Rong Huang, Kun Wang, Zhi Shi, Jin Ye   +16 more
doaj   +1 more source

Introduction to Single‐Cell Physiologically‐Based Pharmacokinetic (scPBPK) Models

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT The current investigation introduces single‐cell physiologically based pharmacokinetic (scPBPK) models to gain insight into drug disposition at the cellular scale. The transition from standard PBPK (sPBPK) models to scPBPK models required depiction of expression‐dependent (ED) processes, such as drug metabolism or membrane transport.
Anshul Saini, James M. Gallo
wiley   +1 more source

Expression and prognostic value of the WEE1 kinase in gliomas

, 2016
High-grade gliomas have an aggressive clinical course and new clinical biomarkers and therapeutic targets are highly needed. WEE1 is a regulator of the G2 checkpoint in glioblastoma (GBM) cells.
Hansen, Steinbjørn; id_orcid, Kristensen, Bjarne Winther, Hermansen, Simon Kjær; id_orcid, Hjelmborg, Jacob v. B.; id_orcid, Music, Darija, Dahlrot, Rikke Hedegaard; id_orcid, de Stricker, Karin   +6 more
core   +1 more source

WEE1 is negatively regulated by YTHDF2.

, 2020
(A) Flow cytometry analysis of wild-type and YTHDF2 knockout cells that were synchronized and released from G1/S phase using double thymidine block. (B) Western blot analysis of key proteins that determine mitosis entry.
Zhongyu Zou (8690409), Hui-Lung Sun (143598), Chuan He (178952), Qili Fei (4594216), Ian A. Roundtree (1990252)   +4 more
core   +1 more source

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target

Journal of Hematology & Oncology, 2020
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has recently gained interest, and different DDR inhibitors have been developed. Among them, the most promising ones target the WEE1 kinase family, which has a crucial role
Andrea Ghelli Luserna di Rorà, Claudio Cerchione, Giovanni Martinelli, Giorgia Simonetti   +3 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Cytokinetic effects of Wee1 disruption in pancreatic cancer [PDF]

Cell Cycle, 2016
The Wee1 kinase, which is activated in response to DNA damage, regulates exit from G2 through inhibitory phosphorylation of Cdk1/Cdc2, and is an attractive drug target. However, recent work has highlighted effects of Cdk2 phosphorylation by Wee1 on movement through S-phase, suggesting the potential to sensitize to S-phase specific agents by Wee1 ...
Qing, Chang, Megha, Chandrashekhar, Troy, Ketela, Yaroslav, Fedyshyn, Jason, Moffat, David, Hedley   +5 more
openaire   +2 more sources

Wee1 kinase is expressed in moderately to poorly differentiated HCC.

, 2014
A-C, Wee1 kinase was stained with anti-Wee1 antibodies in surgically resected HCC samples (▾ HCC lesion). Anti-Wee1 antibody staining revealed mostly nuclear localization in Wee1 kinase-positive cells.
Tomomi Kogiso (588185), Hikaru Nagahara (588186), Etsuko Hashimoto (158662), Keiko Shiratori (588189), Masakazu Yamamoto (588188), Shunichi Ariizumi (588187)   +5 more
core   +1 more source

An Ancestral Mechanism of Calmodulin Binding to Cds1 Kinase Inhibits Catalytic Activity

IUBMB Life, Volume 78, Issue 8, August 2026.
ABSTRACT Calmodulin is a highly conserved, calcium (Ca2+) sensor protein that is ubiquitous among eukaryotes. Ca2+ binding to Calmodulin induces a conformational change that facilitates interaction with, and activation of, serine/threonine protein kinases, including members of the CaMK family.
Stephanie A. Manovella, Tingting Wang, Samuel N. Young, Toby A. Dite, Vineet Vaibhav, Steve Binos, Laura F. Dagley, Anh T. N. Nguyen, Anthony R. Means, Janni Petersen, John W. Scott, James M. Murphy, Christopher R. Horne   +12 more
wiley   +1 more source

Substrate Competition as a Source of Ultrasensitivity in the Inactivation of Wee1 [PDF]

Cell, 2007
The mitotic regulators Wee1 and Cdk1 can inactivate each other through inhibitory phosphorylations. This double-negative feedback loop is part of a bistable trigger that makes the transition into mitosis abrupt and decisive. To generate a bistable response, some component of a double-negative feedback loop must exhibit an ultrasensitive response to its
Kim, Sun Young, Ferrell, James E.
openaire   +2 more sources