Results 71 to 80 of about 13,336 (197)

Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells

, 2021
Inhibitors of WEE1 and ATR kinases are considered promising for cancer treatment, either as monotherapy or in combination with chemo- or radiotherapy. Here, we addressed whether simultaneous inhibition of WEE1 and ATR might be advantageous.
Lilli T. E. Bay, Randi G. Syljuåsen, Gro Elise Rødland, Tine T. H. Raabe, Mrinal Joel, Grete Hasvold, Sissel Hauge   +6 more
core   +1 more source

Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1 [PDF]

Cell, 2005
The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis.
Harvey, Stacy L., Charlet, Alyson, Haas, Wilhelm, Gygi, Steven P., Kellogg, Douglas R.   +4 more
openaire   +2 more sources

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Jonathan Cunningham
wiley   +1 more source

miR‐640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance‐Associated Genes in Breast Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT We investigated the potential of miR‐640 to downregulate CDK4/6 inhibitor resistance‐associated genes and evaluated its apoptotic, anti‐metastatic and anti‐proliferative effects, both alone and in combination with abemaciclib in breast cancer cells. miR‐640 was identified via GSE126125 dataset analysis.
Ismail Mert Alkac, Cigir Biray Avci
wiley   +1 more source

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.

PLoS Biology, 2020
The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei, Zhongyu Zou, Ian A Roundtree, Hui-Lung Sun, Chuan He   +4 more
doaj   +1 more source

Toxoplasma gondii‐Derived Soluble Factors Induce G2/M Phase Accumulation and p53‐Associated Mitochondrial Apoptosis in Human Umbilical Cord Mesenchymal Stem Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Toxoplasma gondii infection poses potential risks to stem cell‐based therapeutic applications; however, the effects of parasite‐derived soluble factors on mesenchymal stem cells remain unclear. Here, we investigated the impact of T. gondii‐derived soluble factors (Tg‐SFs) on human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs).
Wei Zhou, Tingyu Chen, Ziping Yang, Jinjing Huang, Xinyi Lai, Jie Liu, Jiaqi Chu, Juanhua Quan   +7 more
wiley   +1 more source

Perturbation of cytokinin and ethylene-signalling pathways explain the strong rooting phenotype exhibited by Arabidopsis expressing the Schizosaccharomyces pombe mitotic inducer, cdc25 [PDF]

, 2012
Background Entry into mitosis is regulated by cyclin dependent kinases that in turn are phosphoregulated. In most eukaryotes, phosphoregulation is through WEE1 kinase and CDC25 phosphatase.
Marchbank, A., Doonan, John, DOONAN J., Prinsen, Els, Angela Marchbank, Rogers Hilary J, Sherong Li, MARCHBANK A., Bruno, Leonardo, PRINSEN E., Li, Sherong, Spadafora Natasha D, Rogers HJ, FRANCIS D., Li Sherong, Doonan J, Diego Albani, Francis D, Parfitt, David, Nieuwland Jeroen, John Doonan, Bitonti MB, Buchanan-Wollaston, Vicky, Natasha Spadafora, Hilary Rogers, Spadafora, Natasha, Rogers, H.J., Vaughn, R., Li S, Parfitt, D., Albani Diego, Bruno Leonardo, Marchbank A, Vaughan R, Nieuwland, Jeroen, BITONTI M. B., Bruno L, Herbert RJ, Spadafora, N.D., Robert Herbert, Marchbank, Angela Maureen, HERBERT R., Li, S., Francis, Dennis, Rhys Vaughan, Albani, Diego Maria, Dennis Francis, Li S., Prinsen Els, Rogers, Hilary J., Leonardo Bruno, Spadafora, Natasha D., SPADAFORA D., PARFITT D., Herbert Robert J, Prinsen E, Vaughan, Rhys, David Parfitt, Jeroen Nieuwland, Francis Dennis, Bruno, L., Herbert, Rob, Bitonti, M.B., Prinsen, E., Maria Beatrice Bitonti, Rogers, Hilary Joan, Els Prinsen, Albani, Diego, Vicky Buchanan-Wollaston, VAUGHAN R., Francis, D. (Dennis), Buchanan-Wollaston Vicky, Spadafora ND, Rogers, Hilary, Herbert, Robert, ROGERS H. R., Nieuwland, J., Albani, D., Parfitt David, Doonan John, Doonan, J., ALBANI D., Buchanan Wollaston V, Buchanan-Wollaston, V., Bitonti, Maria Beatrice, Parfitt D, Nieuwland J, BRUNO L., Marchbank Angela, WOLLASTON B., Bitonti Maria, Francis, D., Marchbank, Angela, Vaughan Rhys, NIEUWLAND J., Bitonti, B.M., Sherong, L., et al.   +97 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Activation domain-dependent degradation of somatic Wee1 kinase

, 2010
Cell cycle progression is dependent upon coordinate regulation of kinase and proteolytic pathways. Inhibitors of cell cycle transitions are degraded to allow progression into the subsequent cell cycle phase.
Smith, Anthony, Smith, A, Cartzendafner, J, Owens, L, Sato, Trey, Caldwell Busby, J, Simanski, S, Squire, Christopher, Cartzendafner, Jeff, Cavett, Valerie, Ayad, NG, Sato, T, Ayad, Nagi G, Simanski, Scott, Owens, Laura, Cavett, V, Caldwell Busby, Jennifer   +16 more
core   +1 more source

Long noncoding RNA LINC01410 promotes the tumorigenesis of neuroblastoma cells by sponging microRNA‐506‐3p and modulating WEE1

Cancer Medicine, 2020
Objective Neuroblastoma (NBL) is an extra‐cranial solid tumor in children. This study was attempted to investigate the regulatory mechanism of long noncoding RNA LINC01410 (LINC01410) on NBL.
Jie Mi, Yang Han, Jin Zhang, Xiwei Hao, Maoqing Xing, Cong Shang   +5 more
doaj   +1 more source