Results 71 to 80 of about 10,965 (175)
MiR-503 enhances the radiosensitivity of laryngeal carcinoma cells via the inhibition of WEE1
Tumor Biology, 2017 Enhancing the sensitivity of laryngeal cells to radiation is crucial for improving the efficacy of laryngeal carcinoma. MicroRNAs are known to play a major role in regulating cellular radiosensitivity.
Huimin Ma +6 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2020 Background: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy.
Reem Ali +7 more
doaj +1 more source
Cell ReportsSummary: DNA damage profoundly affects cancer progression and immune cell function. While research primarily focuses on tumor cells, the effects of DNA damage on immune cells remain understudied.
Ian-Ian Ng +8 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Esophageal squamous cell carcinoma (ESCC) is a common malignant diagnosed cancer with increasing incidence rate and few treatment options. As a specific small-molecule inhibitor of the Wee1 tyrosine kinase, AZD1775 has previously shown potent antitumor ...
Shuning Bi +5 more
doaj +1 more source
WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma
JCI Insight, 2022 CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes.
Rovingaile Kriska M. Ponce +4 more
doaj +1 more source
Spatiotemporal regulations of Wee1 at the G2/M transition
Molecular Biology of the Cell, 2011 Wee1 is a protein kinase that negatively regulates mitotic entry in G2 phase by suppressing cyclin B–Cdc2 activity, but its spatiotemporal regulations remain to be elucidated. We observe the dynamic behavior of Wee1 in Schizosaccharomyces pombe cells and manipulate its localization and kinase activity to study its function.
Masuda, Hirohisa +4 more
openaire +2 more sources
Expression and clinical significance of Wee1 in colorectal cancer
Tumor Biology, 2016 Wee1 is a nuclear kinase regulating cell cycle progression, and has emerged as a promising therapeutic target in cancer. Expression of Wee1 has been associated with poor outcome in certain tumor types, but the prognostic impact and clinical significance in colorectal cancer is unknown.
Eivind Valen, Egeland +5 more
openaire +2 more sources
High WEE1 expression is independently linked to poor survival in multiple myeloma
Blood Cancer JournalCurrent prognostic scores in multiple myeloma (MM) currently rely on disease burden and a limited set of genomic alterations. Some studies have suggested gene expression panels may predict clinical outcomes, but none are presently utilized in clinical ...
Anish K. Simhal +8 more
doaj +1 more source