Results 81 to 90 of about 13,336 (197)

Integrative Transcriptomic and Functional Analysis of PKMYT1 Reveals a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

Hematological Oncology, Volume 44, Issue 4, July 2026.
ABSTRACT Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated PKMYT1 expression in primary CLL samples and analyzed associations with cytogenetic features and clinical ...
Elizabete Cristina Iseke Bispo, Cláudia de Souza Lima Pontes, Jennifer Martins do Nascimento, Fábio Wilson de Lima Alves, Juliana Lott de Carvalho, Antônio Roberto Lucena‐Araujo, Felipe Saldanha‐Araujo   +6 more
wiley   +1 more source

Cloning, transformation and expression of cell cycle-associated protein kinase OsWee1 in indica rice (Oryza sativa L.)

Journal of Genetic Engineering and Biotechnology, 2018
The development process of seed in plants is a cycle of cells which occur gradually and regularly. One of the genes involved in controling this stage is the Wee1 gene.
Frengky H.H. Prasetyo, Bambang Sugiharto, Netty Ermawati   +2 more
doaj   +1 more source

MiR-503 enhances the radiosensitivity of laryngeal carcinoma cells via the inhibition of WEE1

Tumor Biology, 2017
Enhancing the sensitivity of laryngeal cells to radiation is crucial for improving the efficacy of laryngeal carcinoma. MicroRNAs are known to play a major role in regulating cellular radiosensitivity.
Huimin Ma, Rong Lian, Zhiyan Wu, Xiao Li, Wenfa Yu, Yun Shang, Xixia Guo   +6 more
doaj   +1 more source

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma

JCI Insight, 2022
CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes.
Rovingaile Kriska M. Ponce, Nicholas J. Thomas, Nam Q. Bui, Tadashi Kondo, Ross A. Okimoto   +4 more
doaj   +1 more source

NotValdemaras/WEE1-phosphoproteomics: For submission

, 2022
The release contains the code used to analyze the MS ...
NotValdemaras
core   +1 more source

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

Cell Reports
Summary: DNA damage profoundly affects cancer progression and immune cell function. While research primarily focuses on tumor cells, the effects of DNA damage on immune cells remain understudied.
Ian-Ian Ng, Zhihua Zhang, Kaimin Xiao, Minjie Ye, Tingzhong Tian, Yaoji Zhu, Yuan He, Ling Chu, Haidong Tang   +8 more
doaj   +1 more source

Wee1 Inhibitor AZD1775 Effectively Inhibits the Malignant Phenotypes of Esophageal Squamous Cell Carcinoma In Vitro and In Vivo

Frontiers in Pharmacology, 2019
Esophageal squamous cell carcinoma (ESCC) is a common malignant diagnosed cancer with increasing incidence rate and few treatment options. As a specific small-molecule inhibitor of the Wee1 tyrosine kinase, AZD1775 has previously shown potent antitumor ...
Shuning Bi, Qiuren Wei, Zhijun Zhao, Liang Chen, Chaojie Wang, Songqiang Xie   +5 more
doaj   +1 more source

XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib

Therapeutic Advances in Medical Oncology, 2020
Background: PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy.
Reem Ali, Adel Alblihy, Michael S. Toss, Mashael Algethami, Rabab Al Sunni, Andrew R. Green, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source

Characterisation of WEE1 regulation at mitosis

Wee1 is a tyrosine kinase that plays a major role in regulating mitotic entry. Throughout G2 phase, it phosphorylates and inhibits Cdk1, the master mitotic regulator, thereby preventing mitotic entry.
Johnson, V
core   +1 more source

Expression and clinical significance of Wee1 in colorectal cancer

Tumor Biology, 2016
Wee1 is a nuclear kinase regulating cell cycle progression, and has emerged as a promising therapeutic target in cancer. Expression of Wee1 has been associated with poor outcome in certain tumor types, but the prognostic impact and clinical significance in colorectal cancer is unknown.
Eivind Valen, Egeland, Kjersti, Flatmark, Jahn M, Nesland, Vivi Ann, Flørenes, Gunhild M, Mælandsmo, Kjetil, Boye   +5 more
openaire   +2 more sources