Results 101 to 110 of about 13,336 (197)

CHD5 is enriched at the WEE1 promoter.

, 2014
(A) Schematic of the WEE1 locus with the putative WEE1 promoter and direction of transcription indicated. The promoter of the ZNF143 gene is approximately 115 kb upstream of WEE1. The horizontal bars depict the location of primersets used.
Guillaume Adelmant (104610), Jarrod A. Marto (104616), Jinhua Quan (632927), A. Thomas Look (24541), Timur Yusufzai (632928)   +4 more
core   +1 more source

Targeting WEE1 and asciminib suppresses ABL-tyrosine kinase inhibitor-resistant chronic myeloid leukemia cells

Discover Oncology
Background Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the uncontrolled proliferation of white blood cells. Tyrosine kinase inhibitors (TKIs) are the standard treatment; however, resistance to BCR::ABL1 mutations ...
Seiichi Okabe, Mitsuru Moriyama, Akihiko Gotoh, Daigo Akahane   +3 more
doaj   +1 more source

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids. [PDF]

J Med Chem
Syphers JL, Wright JA, Kumar A, To N, Elson L, Krämer A, Müller S, Morasch V, Chang A, Young S, Sloan EK, de Nys R, Silva TN, Vrbanac L, Barratt KR, Leeflang J, Hasan ST, Gable RW, Knapp S, Worthley DL, Mukherjee S, Stockton K, Woods SL, Priebbenow DL, Baell JB.   +24 more
europepmc   +1 more source

Combined Inhibition of Wee1 and Checkpoint Kinases Synergistically Provokes S-Phase Progression and Mitotic Entry, and Promotes Cell Death Under Heat Stress. [PDF]

Genes Cells
Muratani T, Takeya H, Ishibashi R, Kurakawa T, Ikushiro SI, Nagai Y, Tabuchi Y, Kondo T, Furusawa Y.   +8 more
europepmc   +1 more source

WEE1 kinase in cancer: Molecular mechanisms and inhibitor insights. [PDF]

EXCLI J
Kumar A, Paudel KR, Kaur R, Bhatia R.
europepmc   +1 more source

WEE1 wt Allele [PDF]

, 2020
openaire   +1 more source

WEE1 Inhibition as a Novel Therapeutic Strategy in Cutaneous T-Cell Lymphoma. [PDF]

Cancers (Basel)
Özistanbullu D, Bahrami K, Doll M, Reichenbach G, Pöschl SM, Wilhelm R, Stege H, Zöller N, Winkler L, Jäger M, Nicolay JP, Quist SR, Kaufmann R, Meissner M, Schilling B, Kleemann J, Cinatl J, Kippenberger S.   +17 more
europepmc   +1 more source

Computational mapping of productive POI-E3 ligase conformations to guide de novo degrader design: application to WEE1 and PKMYT1 PROTACs. [PDF]

J Cheminform
Nassar H, Schmidt M, Ibrahim HS, Robaa D, Sippl W.   +4 more
europepmc   +1 more source

Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression. [PDF]

J Dev Biol
Pfeiffer S, Fernando LM, Allen AK, Jaramillo-Lambert A.   +3 more
europepmc   +1 more source

WEE1 kinase inhibitor shows promise [PDF]

Nature Reviews Clinical Oncology, 2019
openaire   +2 more sources