Results 21 to 30 of about 13,336 (197)
Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. [PDF]
PLoS ONE, 2014 Transforming growth factor-β1 (TGF-β1) potently inhibits human hepatocellular carcinoma (HCC) cell growth. Here we demonstrated that TGF-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at Tyr15 accompanied by down-regulation of Wee1
Tomomi Kogiso +5 more
doaj +1 more source
Investigation into the stability of WEE1 kinase in plants [PDF]
Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase.
Cook, Gemma S.
core +6 more sources
G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
Radiation Oncology, 2023 Background The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2–7 (EGFRvIII) being amongst the most common genomic mutations.
Meryem H. Cetin +13 more
doaj +1 more source
Molecular Cancer, 2009 Background Wee1 is a tyrosine kinase regulating S-G2 cell cycle transition through the inactivating phosphorylation of CDC2. The inhibition of Wee1 kinase by a selective small molecule inhibitor significantly enhances the anti-tumor efficacy of DNA ...
Mizuarai Shinji +6 more
doaj +1 more source
WEE1-mediated regulation of preMPF and MPF oscillations.
, 2020 (A) Approximated steady-state protein levels from studies by Ovejero et al. [8] using immunoblot analysis for CDK1T, CCNB1T, WEE1T and CDK1P Y15 (i.e. preMPF) in WEE1-expressing U2OS cells following release from synchronization in M phase.
Scott S. Terhune (8677500) +3 more
core +1 more source
miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1
Analytical Cellular Pathology, 2022 Background. Accumulating evidence has demonstrated the role of differentially expressed miRNAs in glioma progression. Our previous bioinformatics analyses revealed a role of miR-138-5p in glioma.
Jianwu Gong +7 more
doaj +1 more source
Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma
Frontiers in Oncology, 2023 Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significantly improved clinical outcome, most patients relapse and develop
Angélique Bruyer +24 more
doaj +1 more source
Microorganisms, 2020 The widely consumed neuroactive compound caffeine has generated much interest due to its ability to override the DNA damage and replication checkpoints.
John P. Alao +3 more
doaj +1 more source
Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation
Molecular Oncology, 2021 Platinum‐based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1)
Xiaoliang Zhao +12 more
doaj +1 more source
Hsp90 phosphorylation, Wee1 and the cell cycle [PDF]
Cell Cycle, 2010 Heat Shock Protein 90 (Hsp90) is an essential molecular chaperone in eukaryotic cells, and it maintains the functional conformation of a subset of proteins that are typically key components of multiple regulatory and signaling networks mediating cancer cell proliferation, survival, and metastasis.
Mehdi, Mollapour +2 more
openaire +2 more sources