Results 21 to 30 of about 10,965 (175)
miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1
Analytical Cellular Pathology, 2022 Background. Accumulating evidence has demonstrated the role of differentially expressed miRNAs in glioma progression. Our previous bioinformatics analyses revealed a role of miR-138-5p in glioma.
Jianwu Gong +7 more
doaj +1 more source
Microorganisms, 2020 The widely consumed neuroactive compound caffeine has generated much interest due to its ability to override the DNA damage and replication checkpoints.
John P. Alao +3 more
doaj +1 more source
Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma
Frontiers in Oncology, 2023 Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significantly improved clinical outcome, most patients relapse and develop
Angélique Bruyer +24 more
doaj +1 more source
Hsp90 phosphorylation, Wee1 and the cell cycle [PDF]
Cell Cycle, 2010 Heat Shock Protein 90 (Hsp90) is an essential molecular chaperone in eukaryotic cells, and it maintains the functional conformation of a subset of proteins that are typically key components of multiple regulatory and signaling networks mediating cancer cell proliferation, survival, and metastasis.
Mehdi, Mollapour +2 more
openaire +2 more sources
ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
The Journal of Clinical Investigation, 2023 WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear.
Jie Li +16 more
doaj +1 more source
Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation
Molecular Oncology, 2021 Platinum‐based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1)
Xiaoliang Zhao +12 more
doaj +1 more source
Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma
Frontiers in Pharmacology, 2018 WEE1 is a tyrosine kinase that regulates G2/M cell cycle checkpoint and frequently overexpressed in various tumors. However, the expression and clinical significance of WEE1 in human laryngeal squamous cell carcinoma (LSCC) are still unknown.
Meng-Ling Yuan +14 more
doaj +1 more source
Journal of Dental Sciences, 2022 Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation.
Yu-Hsueh Wu +3 more
doaj +1 more source
WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia
Haematologica, 2020 T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors.
Juncheng Hu +14 more
doaj +1 more source
A Wee1 checkpoint inhibits anaphase onset [PDF]
Journal of Cell Biology, 2013 Cdk1 drives both mitotic entry and the metaphase-to-anaphase transition. Past work has shown that Wee1 inhibition of Cdk1 blocks mitotic entry. Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation of the mitotic form of the anaphase-promoting complex/
Lianga, Noel +7 more
openaire +2 more sources