Results 101 to 110 of about 1,652 (181)

DIPG-38. VAL-083 IN COMBINATION WITH AZD1775 FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA [PDF]

Neuro Oncol
Abstract BACKGROUND Diffuse midline gliomas (DMGs) are malignant pediatric brain tumors characterized by H3K27M mutation and global genome hypomethylation. This results in enhanced transcription of MGMT, a DNA-repair enzyme, rendering alkylating chemotherapeutics ineffective.
Subramaniam, Bavani, Roy, Debasish, Woldegerima, Ayda, Przystal, Justyna, Zhang, Jie, Laternser, Sandra, Kritzer, Bettina, Yadavilli, Sridevi, Mueller, Sabine, Packer, Roger, Nazarian, Javad   +10 more
europepmc   +2 more sources

DataSheet_2_Wee1 Inhibitor AZD1775 Effectively Inhibits the Malignant Phenotypes of Esophageal Squamous Cell Carcinoma In Vitro and In Vivo.pdf

, 2019
Esophageal squamous cell carcinoma (ESCC) is a common malignant diagnosed cancer with increasing incidence rate and few treatment options. As a specific small-molecule inhibitor of the Wee1 tyrosine kinase, AZD1775 has previously shown potent antitumor ...
Zhijun Zhao (784822), Songqiang Xie (1750744), Qiuren Wei (7119242), Chaojie Wang (2175530), Liang Chen (73736), Shuning Bi (5775887)   +5 more
core   +1 more source

CNSC-10. CDK7 INHIBITION MITIGATES AZD1775 RESISTANCE VIA CHROMATIN REPROGRAMMING IN MYC-MB

Neuro-Oncology
Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children, comprising ~20% of pediatric brain tumors. MB is a heterogeneous disease, with clinical outcomes heavily influenced by molecular subgroups. Among these, Group 3 MB, characterized by MYC amplification, exhibits the poorest prognosis, with a high ...
Smart, Kiara, Vibhakar, Rajeev, Veo, Bethany   +2 more
openaire   +2 more sources

Figure S6 from A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia

, 2017
Combined AZD1775 and olaparib treatment reduces cell viability and enhances apoptosis in a murine AML cell line. A. A murine MLL-ENL, FLT3-ITD+ AML cell line was treated in vitro with DMSO (vehicle control), olaparib (2 uM), and/or AZD1775 (200 nM) for ...
Tamara B. Garcia (8533719), Lori Gardner (14935568), Craig T. Jordan (210141), Chengjing Zhou (3907645), Sujatha Venkataraman (194808), Susan P. Fosmire (14919194), Dmitry Baturin (390190), Rajeev Vibhakar (247074), Christopher C. Porter (8533728), Jonathan C. Snedeker (15074359)   +9 more
core   +1 more source

Supplementary Figure S4 from PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer

, 2016
(A) Experimental design timeline for apoptosis assays. (B) Caspase-3 activity assay in H522 cells (left panel) which express both WEE1 and PAXIP1 and in H1395 cells (right panel) which express PAXIP1 but no WEE1.
Eric B. Haura (239755), Nicholas T. Woods (7321022), Uwe Rix (236984), Ankita Jhuraney (15074326), Alvaro N. Monteiro (3825559), Lily Rix (15074329), W. Douglas Cress (10987635), Fumi Kinose (846843), Gabriela Wright (237756), Elizabeth Remily-Wood (1843075), Jhanelle E. Gray (4094155), Stephen G. Brantley (15074335), John M. Koomen (228649), Jodi L. Kroeger (15074332)   +13 more
core   +1 more source

Supplementary Figures, Legends and Tables from Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition

, 2019
Figure S1. Severe DNA replication inhibition in UM-SCC-74a HNSCC line and untransformed primary cells. Figure S2. Efficiency of WEE1 inhibition by AZD1775. Figure S3. Cell cycle progression and ï §H2AX response in the p53 mutant PCI-15B cells. Figure S4.
Ahmed Diab (10857342), Hee Yeon Kim (847060), Eduardo Mendez (5648611), Michael Kao (14987832), Keffy Kehrli (15079422), Julia Sidorova (434719)   +5 more
core   +1 more source

Supplementary Material from Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

, 2017
This file contains the supplementary figures and figure legends. Figure S1: WEE1 is overexpressed in small cell lung cancer (SCLC) compared with non-small cell lung cancer cell lines, and targeting WEE1 with AZD1775 prevents sub-G1 accumulation of WEE1 ...
Jing Wang (6206297), Lixia Diao (184400), Pan Tong (698977), Triparna Sen (510712), Lerong Li (14926781), Youhong Fan (6585116), Lauren Averett Byers (14175449), Jennifer Hoff (15002378), John V. Heymach (9603543)   +8 more
core   +1 more source

UEG Week 2024 Moderated Posters

United European Gastroenterology Journal, Volume 12, Issue S8, Page 201-664, October 2024.
wiley   +1 more source

Supplementary Figure S1-S10 and Table S1 from Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation

, 2017
Supplementary Figure S1. Synergistic effects of vorinostat and AZD1775 in vitro in established isogenic pair HNSCC cell lines with known TP53 mutational status. Supplementary Figure S2.
Faye Johnson (11483644), Abdullah A. Osman (14920271), Curtis R. Pickering (13115535), Jeffrey N. Myers (222748), Noriaki Tanaka (8478), Nene N. Kalu (14933612), Tseng-Cheng Chen (558642), Mitchell J. Frederick (14871290), Antje Lindemann (15008477), Walter N. Hittelman (1274439), Siqing Fu (160695), Marek Kimmel (39636), Frederico O. Gleber-Netto (13907530), Ameeta A. Patel (14921678), Hideaki Takahashi (1269621), Jing Wang (6206297), Xiayu Rao (790781), Natalie L. Silver (14997050), Roman Jaksik (6309656), Jiping Wang (1319202), Lin Tang (65412)   +20 more
core   +1 more source

Figure S7 from A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia

, 2017
Combined AZD1775 and olaparib treatment is tolerated in vivo. A and B. Mice injected with a murine AML cell line were treated as described in the text. Complete blood counts (A) and weights (B) were obtained 10 days after leukemia transfer.
Tamara B. Garcia (8533719), Lori Gardner (14935568), Craig T. Jordan (210141), Chengjing Zhou (3907645), Sujatha Venkataraman (194808), Susan P. Fosmire (14919194), Dmitry Baturin (390190), Rajeev Vibhakar (247074), Christopher C. Porter (8533728), Jonathan C. Snedeker (15074359)   +9 more
core   +1 more source