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ACS Sustainable Chemistry and Engineering, 2019 Azelaic acid is an α,ω-dicarboxylic acid with nine carbons and has multiple applications in plastic and cosmetic industries. Chemical oxidation of oleic acid with ozone (called ozonolysis) allows the production of azelaic acid and a major byproduct of ...
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Cosmeceutical Aptitudes of Azelaic Acid
Current Drug Research Reviews, 2021Azelaic acid (AZA) is a white crystalline dicarboxylic acid naturally found in grains, rye, and barley. AZA has substantial biological and therapeutic abilities (viz a viz) its anti-inflammatory, anti-oxidant, anti-keratinizing, anti-microbial properties, etc., which contribute to its applicability in the management of mild to harsh dermatological ...
Supriya Kumari Singh +4 more
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Sustainable Process for Production of Azelaic Acid Through Oxidative Cleavage of Oleic Acid
JAOCS, Journal of the American Oil Chemists' Society, 2015 This work describes two sustainable methods for prodn. and purifn. of azelaic acid (AA) to replace the current process of ozonolysis of oleic acid (OA). The first proceeds in two steps, coupling smooth oxidn. of OA to 9,10-dihydroxystearic acid (DSA)
Maria Elena Cucciolito +2 more
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Journal of the American Academy of Dermatology, 1987
This review is an update on the literature accumulated over the past 10 years following the original observation that azelaic acid, a naturally occurring and nontoxic C9 dicarboxylic acid, possesses significant biologic properties and a potential as a therapeutic agent.
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This review is an update on the literature accumulated over the past 10 years following the original observation that azelaic acid, a naturally occurring and nontoxic C9 dicarboxylic acid, possesses significant biologic properties and a potential as a therapeutic agent.
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Percutaneous absorption of azelaic acid in humans
Experimental Dermatology, 1992Abstract Six healthy male volunteers received a single topical treatment with 5 g of an anti‐acne cream containing 20% azelaic acid (AzA) onto the face, the chest and the upper back. One week later 1 g of AzA was given orally to the same subjects as aqueous microcrystalline suspension.
U, Täuber, C, Weiss, H, Matthes
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The in vitro antimicrobial effect of azelaic acid
British Journal of Dermatology, 1986Various strains of cutaneous micro-organisms were tested in vitro for their survival rates in 0.5 mol/l (8.4% w/v) azelaic acid solution. All bacterial strains exhibited large reductions in viability (at least 40-fold) over a 24 h test period, but little response was noted with Pityrosporum ovale.
J P, Leeming, K T, Holland, R A, Bojar
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Azelaic Acid: Properties and Mode of Action
Skin Pharmacology and Physiology, 2013Acne is a common skin disorder that can be problematic for adults as well as for adolescents. It has several key pathophysiological features such as follicular hyperkeratosis, elevated <i>Propionibacterium acnes </i>proliferation, and reactive inflammation, all of which should be targeted for an optimal outcome.
M A, Sieber, J K E, Hegel
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Azelaic acid therapy in disorders of pigmentation
Clinics in Dermatology, 1989Abstract Azelaic acid (COOH(CH 2 ) 7 COOH), is a medium chain-length saturated, 9-carbon atom dicarboxylic acid, which has recently been shown to have important biologic activities and some useful practical therapeutic applications. It can be obtained by oxidation of fatty acids, such as oleic acid, which are unsaturated in the 9-C position, and in ...
A C, Breathnach +3 more
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American Journal of Clinical Dermatology, 2004
Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double-blind, multicenter studies involving patients with moderate papulopustular facial rosacea, twice-daily topical application of azelaic acid 15% gel to the
James E, Frampton, Antona J, Wagstaff
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Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double-blind, multicenter studies involving patients with moderate papulopustular facial rosacea, twice-daily topical application of azelaic acid 15% gel to the
James E, Frampton, Antona J, Wagstaff
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The sampling and determination of azelaic acid in air
American Industrial Hygiene Association Journal, 1978Air samples of azelaic acid (nonanedioic acid), were collected on polyvinyl chloride (PVC) filters, extracted with ethanol, derivatized with N, O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), containing 1% trimethylchlorosilane (TMCS) and analyzed by gas-liquid chromatography.
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