Strategies in the synthesis of dibenzo[b,f]heteropines [PDF]
Beilstein Journal of Organic Chemistry, 2023 The dibenzo[b,f]azepine skeleton is important in the pharmaceutical industry, not only in terms of existing commercial antidepressants, anxiolytics and anticonvulsants, but also in reengineering for other applications. More recently, the potential of the
David I. H. Maier +2 more
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A DFT Study on the Mechanism of Selective Formation of Substituted Azepines From 1-Azabutadienes and Cyclopropanes. [PDF]
ChemistryThe origin of the unusual regioselectivity in the Mg‐catalyzed cyclization of azadiene‐type imines with cyclopropanes is elucidated by DFT calculations. Although five‐membered rings are typically favored, energy decomposition analysis reveals that severe steric congestion induces a highly distorted transition state, rendering the five‐membered pathway ...
Kobayashi R +5 more
europepmc +2 more sources
Fluorescent pyridine phosphonium salts via transmutation of metallabenzenes [PDF]
Nature CommunicationsMetallabenzenes are recognized as a unique class of aromatic compounds, not only of structural and theoretical interest but also as platforms to design powerful transformations.
Yaowei Zhang +5 more
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Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was evaluated
Mohammed Farrag El-Behairy +8 more
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ElectronPersistent and stable radicals remain challenging to generate via photoinduction, despite their vast potential in magnetics and energy storage. Trisubstituted amines offer a promising platform for photoinduced radicals, but rapid charge recombination ...
Lingjuan Chen +3 more
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Synthesis of Substituted Oxo-Azepines by Regio- and Diastereoselective Hydroxylation
Molecules, 2017 Substituted seven-membered N-heterocycles are prevalent bioactive epitopes and useful synthons for preparing enzyme inhibitors or molecular recognition systems.
Peter Karuso, Fei Liu, Karuso Peter
exaly +3 more sources
Synthesis and molecular docking simulations of novel azepines based on quinazolinone moiety as prospective antimicrobial and antitumor hedgehog signaling inhibitors [PDF]
Scientific ReportsA series of novel azepine derivatives based on quinazolinone moiety was synthesized through the reaction of quinazolinone chalcones (2a–d) either with 2-amino aniline in acidic medium to give diazepines (3a–d) or with 2-aminophenol to offer oxazepine (4a–
Ahmed A. Noser +4 more
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Molecules, 2022 An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary ...
Anna N. Philippova +4 more
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Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution [PDF]
Journal of the Serbian Chemical Society, 2016 A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine).
Božinović Nina +2 more
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Synthesis and antimicrobial activity of azepine and thiepine derivatives [PDF]
Journal of the Serbian Chemical Society, 2015 A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity.
Božinović Nina +4 more
doaj +1 more source