Results 11 to 20 of about 2,248 (160)

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies

Scientific Reports, 2023
In this strategy, we attempt to design various novel nitrogen-rich heterocycles in one molecule. Green, simple, and efficient aza-annulations of an active, versatile building block, 1-amino-4-methyl-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (1 ...
Aisha Y. Hassan, Sara N. Shabaan, Samiha A. El-Sebaey, Eman S. Abou-Amra   +3 more
doaj   +1 more source

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents

Scientia Pharmaceutica, 2023
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the oldest and most widely used groups of drugs nowadays. However, the problem of searching for and creating new NSAIDs remains open, primarily due to the risks owing to their short- and long-term
Sergii Demchenko, Roman Lesyk, Oleh Yadlovskyi, Serhii Holota, Sergii Yarmoluk, Sergii Tsyhankov, Anatolii Demchenko   +6 more
doaj   +1 more source

The Reactions of 6-(Hydroxymethyl)-2,2-dimethyl-1-azaspiro[4.4]nonanes with Methanesulfonyl Chloride or PPh₃-CBr₄

Molecules, 2021
Activation of a hydroxyl group towards nucleophilic substitution via reaction with methanesulfonyl chloride or PPh3-CBr4 system is a commonly used pathway to various functional derivatives.
Yulia V. Khoroshunova, Denis A. Morozov, Andrey I. Taratayko, Sergey A. Dobrynin, Ilia V. Eltsov, Tatyana V. Rybalova, Yulia S. Sotnikova, Dmitriy N. Polovyanenko, Nargiz B. Asanbaeva, Igor A. Kirilyuk   +9 more
doaj   +1 more source

Ring Expansion of Vinylaziridines through the Strain-Release Pericyclic Reaction: Recent Developments and Applications

Molecules, 2013
Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj   +1 more source

Synthesis, Antibacterial and Antifungal Activity of New 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine Quaternary Salts

Molecules, 2021
A series of novel 3-aryl-5H-pyrrolo[1,2-a]imidazole and 5H-imidazo[1,2-a]azepine quaternary salts were synthesized in 58–85% yields via the reaction of 3-aryl-6, 7-dihydro-5H-pyrrolo[1,2-a]imidazoles or 3-aryl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepines
Sergii Demchenko, Roman Lesyk, Oleh Yadlovskyi, Johannes Zuegg, Alysha G. Elliott, Iryna Drapak, Yuliia Fedchenkova, Zinaida Suvorova, Anatolii Demchenko   +8 more
doaj   +1 more source

Predicted Reversal in N-Methylazepine/N-Methyl-7-azanorcaradiene Equilibrium upon Formation of Their N-Oxides

Molecules, 2020
Density functional calculations and up to five different basis sets have been applied to the exploration of the structural, enthalpy and free energy changes upon conversion of the azepine to the corresponding N-oxide.
René Fournier, Alexa R. Green, Arthur Greenberg, Edward Lee-Ruff, Joel F. Liebman, Anita Rágyanszki   +5 more
doaj   +1 more source

5,5,7,7-Tetrametyl-6,7-dihydro-5H-dibenzo[c,e]azepine

Molbank, 2023
5,5,7,7-Tetrametyl-6,7-dihydro-5H-dibenzo[c,e]azepine has been synthesized as a possible pro-chiral (or tropos) unit for the construction of a chiral catalyst and as a molecular chirality sensor for the absolute configuration assignment by chiroptical ...
Roberto Bisaccia, Patrizia Scafato, Daniele Casarini, Stefano Superchi   +3 more
doaj   +1 more source

Enantioselective Olefin Epoxidation Using Novel Doubly Bridged Biphenyl Azepines as Catalysts

CHIMIA, 2007
Enantiopure (diastereomeric) doubly bridged biphenyl azepines prepared from (S)-3,3-dimethylbutan-2-amine and (S)-1-phenylpropylamine can be – as a function of the exocyclic side chain – either effective catalysts for the enantioselective ...
Roman Novikov, Jérôme Vachon, Jérôme Lacour   +2 more
doaj   +1 more source

Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro[3,2-d]pyrrolo[1,2-a]pyrimidines, Pyridofuro[3,2-d]pyrido[1,2-a]pyrimidines and Pyridofuro[3′,2′:4,5]pyrimido[1,2-a]azepines

Molecules, 2021
Background: Neurotic disturbances, anxiety, neurosis-like disorders, and stress situations are widespread. Benzodiazepine tranquillizers have been found to be among the most effective antianxiety drugs.
Samvel N. Sirakanyan, Domenico Spinelli, Athina Geronikaki, Victor Kartsev, Elmira K. Hakobyan, Anthi Petrou, Ruzanna G. Paronikyan, Ivetta M. Nazaryan, Hasmik H. Akopyan, Anush A. Hovakimyan   +9 more
doaj   +1 more source