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Unprecedented nucleophile-promoted 1,7-S or Se shift reactions under Pummerer reaction conditions of 4-alkenyl-3-sulfinylmethylpyrroles

Beilstein Journal of Organic Chemistry, 2018
A unique 1,7-S- and Se-shift reaction under Pummerer reaction conditions of 4-alkenyl-3-sulfinyl- and seleninylpyrroles was described. The usual Pummerer reaction of 4-(alkenylaminomethyl)-3-phenylsulfinylpyrroles and a successive reaction with ...
Takashi Go +6 more
doaj +1 more source

Access to pyrrolo-pyridines by gold-catalyzed hydroarylation of pyrroles tethered to terminal alkynes

Beilstein Journal of Organic Chemistry, 2011
In a simple procedure, the intramolecular hydroarylation of N-propargyl-pyrrole-2-carboxamides was accomplished with the aid of gold(III) catalysis. The reaction led to differently substituted pyrrolo[2,3-c]pyridine and pyrrolo[3,2-c]pyridine derivatives
Elena Borsini +5 more
doaj +1 more source

SYNTHESIS AND CHARACTERIZATION OF 3-ARYL-5H,13AH-QUINOLINO(3,2-F) (1,2,4)TRIAZOLO(4,3-B)(1,2-DIAZA-4-SULPHO)AZEPINES: IN VITRO ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY

Indonesian Journal of Chemistry, 2011
3-Aryl-5H,13aH-quinolino(3,2-f)(1,2,4)triazolo(4,3-b)(1,2-diaza-4-sulpho)azepines [2a-i] have been prepared by the cyclisation of 5-aryl-4-amino-3-mercapto-1,2,4-triazole by reaction with 2-chloro-3-formylquinoline in catalytic presence of p-toluene ...
Hemant Panwar, Shishupal Singh
doaj +1 more source

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson +13 more
wiley +2 more sources

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel +5 more
wiley +1 more source

Diffusion of Carbamazepine in Hydrophobic Zeolites: A Comparative Study Using Classical and Machine‐Learned Potentials

Chemistry – A European Journal, EarlyView.
Can hydrophobic, shape‐selective zeolites efficiently remove the persistent pharmaceutical CBZ from water? This work moves beyond the static picture of interaction energies by modeling diffusion with umbrella sampling and machine‐learned potentials. Even high intrinsic diffusion barriers can be overcome through exergonic adsorption from water, yielding
Jakob Brauer +4 more
wiley +1 more source

Thermoplastic‐Resin Transfer Molding Technology: Development and Challenges Toward Industrialization

Polymer Composites, EarlyView.
Illustration of the key aspects involved in the manufacture of thermoplastic composites by T‐RTM highlighting the relationships between raw materials, resin mixing strategies, polymerization parameters, and processing equipment ranging from laboratory to industrial scale. ABSTRACT Driven by increasingly stringent international environmental regulations,
Filipe P. Martins +4 more
wiley +1 more source

Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization

Angewandte Chemie, Volume 138, Issue 8, 16 February 2026.
We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources

Synthesis and anаlgеsic properties of (3-allyl-4-aryl-3H-thiazol-2-ylidene)-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]amine derivatives

Фармацевтичний журнал, 2018
In recent years, attention to itself attracted by the problem of pain treatment, which is due to a noticeable increase in patients, especially the able-bodied age. The aim of the study was to synthesize substances with potentially analgesic properties in
S. A. Demchenko +5 more
doaj +1 more source

Rh(III)‐Catalyzed [4 + 3] Annulation for Construction of Heterocycle‐Fused Azepines

Advanced Synthesis &Catalysis, Volume 368, Issue 13, 2 July 2026.
Rhodium(III)‐catalyzed [4 + 3] annulation of 2‐arylquinazolinones with allyl ethers enables the facile synthesis of heterocycle‐fused azepines. This step‐economical protocol proceeds via CH and NH functionalization, accommodating diverse heteroatom‐ and polyaromatic‐substituted substrates to deliver structurally varied fused azepines efficiently and ...
Shreedhar Devkota +5 more
wiley +1 more source

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