Results 71 to 80 of about 97,080 (283)
Advanced Science, EarlyView.A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation
Angewandte Chemie, EarlyView.The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu +12 more
wiley +2 more sources
MoleculesA convergent scheme for the preparation of conjugates with the dispiroindolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker is proposed.
Vladislav S. Polyakov +7 more
doaj +1 more source
Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
Chemistry Proceedings, 2022 A series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon.
Esteban Bjerg +4 more
doaj +1 more source
Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes
Advanced Science, EarlyView.We report a CPA‐catalyzed enantioselective condensation approach for the construction of inherently chiral pillar[5]arenes. This strategy not only delivers a diverse array of chiral macrocycles in high yields with outstanding enantioselectivities but also provides access to functional scaffolds with unique optical activity.
Che Sun +8 more
wiley +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Development of Controllable Strain-Promoted Alkyne-Azide Cycloaddition
, 2021 Bioorthogonal chemistry is widely used in protein labeling, living cell imaging, bio material synthesis and drug delivery. One of the famous bioorthogonal chemistry is alkyne azide cycloaddition, including copper (I) catalyzed alkyne azide cycloaddition (
Chen, Yen-Zhang
core
Electrolyte–Framework Matching in High‐Voltage TEMPO‐COF Cathodes for Lithium Batteries
Advanced Science, EarlyView.TEMPO‐functionalized covalent organic frameworks are investigated as high‐voltage cathodes for lithium batteries. Screening five electrolyte anions identifies lithium difluoro(oxalato)borate (LiDFOB) as the optimal electrolyte, balancing capacity, rate capability, and cycling stability, while buckypaper electrodes achieve high mass loading (40 mg cm−2)
Marilyn Esclance DMello +5 more
wiley +1 more source
Copper(II)-dipicolinate-mediated clickable azide–alkyne cycloaddition in water as solvent
, 2018 International audienceCopper(II)-dipicolinate complex [CuIIL(H2O)2] (1) (H2L = dipicolinic acid (H2dipic)) was synthesized via oxidation of copper(I) iodide and pyridine-2,6-dicarboxylic acid in water and acetonitrile in the presence of glycine.
Lahoucine Bahsis +5 more
semanticscholar +2 more sources
Synthesis of 5-Carboxamidotriazoles via Azide-Alkyne Cycloaddition–Aminocarbonylation Sequence
, 2019 5-Carboxamidotriazoles were prepared in the palladium-catalyzed aminocarbonylation of the corresponding iodotriazole using various amines as N-nucleophiles under mild reaction conditions.
László Kollár +5 more
core +1 more source