Results 91 to 100 of about 97,080 (283)

A flow platform for degradation-free CuAAC bioconjugation

Nature Communications, 2018
Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use.
Marine Z. C. Hatit, Linus F. Reichenbach, John M. Tobin, Filipe Vilela, Glenn A. Burley, Allan J. B. Watson   +5 more
doaj   +1 more source

Access to three-arm star block copolymers by a consecutive combination of the copper(I)-catalyzed azide-alkyne cycloaddition and the RAFT hetero Diels-Alder concept

, 2008
Three-arm star block copolymers have been synthesized from linear polystyrene (PS) and poly(ε-caprolactone) (PCL) building blocks. Through the use of an α-diene-ω-alkyne functionalized PCL, the PS-b-PCL stars have been synthesized via either forming the ...
Christopher Barner‐Kowollik, Sebastian Sinnwell, Stenzel, M. H., Martina H. Stenzel, Andrew J. Inglis, Sinnwell, S., Barner-Kowollik, C., Inglis, A. J.   +7 more
core   +1 more source

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

Molecules, 2013
The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of ...
Pramod K. Avti, Dusica Maysinger, Ashok Kakkar   +2 more
doaj   +1 more source

Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers

ChemistryOpen
We report the first example of self‐assembled monolayers (SAMs) incorporating a cyclobutene‐substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron‐demand Diels–Alder (IEDDA) cycloadditions. Mixed
Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault   +5 more
doaj   +1 more source

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry

Molecules, 2012
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Wei Gong, Tim Efthymiou, Jean-Paul Desaulniers   +2 more
doaj   +1 more source

Functionalization of polyfluorene-wrapped carbon nanotubes via copper-mediated azide–alkyne cycloaddition

, 2018
Copper-mediated azide–alkyne cycloaddition enables quantitative functionalization of polymer-nanotube complexes containing azide moieties in the polymer side chains.
Darryl Fong, Grace M. Andrews, Alex Adronov   +2 more
core   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

On-Surface Azide–Alkyne Cycloaddition on Au(111)

, 2016
We present [3 + 2] cycloaddition reactions between azides and alkynes on a Au(111) surface at room temperature and under ultrahigh vacuum conditions. High-resolution scanning tunneling microscopy images reveal that these on-surface cycloadditions occur ...
Harry Mönig (1424392), Gernot Langewisch (1424410), Philipp Alexander Held (1895485), Jörn-Holger Franke (1895482), Harald Fuchs (1424398), Hendrik Wagner (1828684), Oscar Díaz Arado (1424407), Armido Studer (1350438)   +7 more
core   +1 more source

Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

eLife, 2019
The functional mechanisms of membrane proteins are extensively investigated with cysteine mutagenesis. To complement cysteine-based approaches, we engineered a membrane protein with thiol-independent crosslinkable groups using azidohomoalanine (AHA), a ...
Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz   +2 more
doaj   +1 more source

Nickel-catalyzed Chemo- and Regioselective Azide???Alkyne Cycloaddition

, 2022
The metal-catalyzed cycloaddition is straightforward pathway to make functionalized heterocyclic frameworks. It has been challenging to achieve reactivity-controlled metal-catalyzed azide???alkyne cycloadditions for chemoselectivity of internal alkynes ...
Jeong, Seo Young, Hong, Sung You
core