Results 91 to 100 of about 28,418 (220)

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

Molecules, 2013
The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of ...
Pramod K. Avti, Dusica Maysinger, Ashok Kakkar   +2 more
doaj   +1 more source

Click chemistry surface functionalization for resonant micro-cavity sensors [PDF]

, 2015
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group.
Alabi, Akinleye C., Armani, Andrea M., Davis, Mark E., Flagan, Richard C., Fraser, Scott E.   +4 more
core   +1 more source

Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers

ChemistryOpen
We report the first example of self‐assembled monolayers (SAMs) incorporating a cyclobutene‐substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron‐demand Diels–Alder (IEDDA) cycloadditions. Mixed
Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault   +5 more
doaj   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]

, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu, Dowdy, Steven F, Huggins, Ian J, Jadhav, Satish, Medina, Carlos A, Springer, Aaron D, van den Berg, Arjen   +6 more
core   +1 more source

Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]

, 2018
Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn, Hsieh, Hsiao-Wu, Park, Simon S   +2 more
core   +1 more source

Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

eLife, 2019
The functional mechanisms of membrane proteins are extensively investigated with cysteine mutagenesis. To complement cysteine-based approaches, we engineered a membrane protein with thiol-independent crosslinkable groups using azidohomoalanine (AHA), a ...
Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz   +2 more
doaj   +1 more source

Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties [PDF]

, 2014
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety ...
Abboud J.-L. M., Anderson C. B., Astruc D., Badèche S., Baltz T., Beyer B., Bock V. D., Borissova A. O., Calladine J. A., Carvalho I., Chong D., Clough M. C., Dallagi T., David P. Day, David. L. Hughes, Dietmar Steverding, Evrard D., Geiger W. E., Geiger W. E., Gil M. V., Glans L., Gregory G. Wildgoose, Gritzner G., Happ B., Hirano T., Hirumi H., Holovics T. C., Huber W., Huisgen R., Jaschinski T., Kee J. W., Kilpin K. J., Kolb H. C., Kolb H. C., Lage M. L., Lawrence E. J., Laws D. R., Laws D. R., Leroux Y. R., Leroux Y. R., Liu Y., Lunquist R. T., Ornelas C., Ornelas C., Otón F., Otón F., Rapakousiou A., Romero T., Romero T., Romero T., Schweinfurth D., Schweinfurth D., Schweinfurth D., Sheridan M. V., Steverding D., Sünkel K., Thomas Dann, To T. T., Vasily S. Oganesyan, Yoo E. J.   +59 more
core   +1 more source

Bionanomaterials from plant viruses [PDF]

, 2015
Plant virus capsids have emerged as useful biotemplates for material synthesis. All plant virus capsids are assembled with high-precision, three-dimensional structures providing nanoscale architectures that are highly monodisperse, can be produced in ...
Aljabali, Alaa A. A., Evans, David
core   +2 more sources

High Yield Branched Puromycin Linker Design Enables Efficient cDNA Display and Chemical Modification of Peptides

Biotechnology and Bioengineering, EarlyView.
A novel puromycin linker for cDNA display was synthesized via SPAAC reaction. Its functionality was confirmed by recovering intact DNA after selection against EpCAM. The system also enabled the verification of bicyclic peptides during display, demonstrating its utility for constructing and screening structurally complex peptide libraries.
Simon Schneider, Melanie Boll, Matthias Eder, Ann‐Christin Eder   +3 more
wiley   +1 more source

Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment

EngMedicine
With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors.
Yun Yin, Xiaoyang Liu, Xuemei Li, Gaolin Liang   +3 more
doaj   +1 more source