Results 101 to 110 of about 12,849 (199)

On-Surface Azide-Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts? [PDF]

Langmuir, 2022
Li T, Dief EM, Kalužná Z, MacGregor M, Foroutan-Nejad C, Darwish N.   +5 more
europepmc   +1 more source

Sustainable and Programmable Hydrogels for Bone Regeneration: A Perspective on Green Synthesis and Precision Fabrication

SusMat, EarlyView.
The clinical translation of natural hydrogels is often hindered by a fundamental conflict. Green synthesis prioritizes biosafety through mild and non‐toxic conditions, whereas precision manufacturing demands mechanical robustness and structural fidelity.
Jiaxin Wu, Xu Wang, Hanfei Li, Xibo Pei, Hao Feng, Jian Wang   +5 more
wiley   +1 more source

Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews, Thomas M. Richardson, Dean D. Roberts, Aitor Maestro, Timothy A. Hilton, Lia Sotorrios, Carlos Martín‐Fernández, Luca Craciunescu, Frederik Peschke, Aidan P. McKay, Stuart A. Macgregor, Glenn A. Burley, Allan J. B. Watson   +12 more
wiley   +2 more sources

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma, Erika McCarthy, N. Sanjeeva Murthy, Cameron McGovern, Zhenyu Han, Şölen Ekesan, Subhajit Nandi, Advik Sirimarapu, Wilma K. Olson, Darrin M. York, Yuwei Gu   +10 more
wiley   +2 more sources

Cellulose Acetate-Supported Copper as an Efficient Sustainable Heterogenous Catalyst for Azide-Alkyne Cycloaddition Click Reactions in Water. [PDF]

Int J Mol Sci, 2023
Stiriba SE, Bahsis L, Benhadria E, Oudghiri K, Taourirte M, Julve M.   +5 more
europepmc   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide-Alkyne Cycloaddition. [PDF]

Polymers (Basel), 2023
Taguchi R, Nakahata M, Kamon Y, Hashidzume A.   +3 more
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 6, Page 1798-1823, November 2026.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source