Results 101 to 110 of about 97,080 (283)
Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment
EngMedicineWith their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors.
Yun Yin +3 more
doaj +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 3-Azido-1-propyne oligomer (oligoAP) samples, prepared by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) polymerization, were quarternized quantitatively with methyl iodide in sulfolane at 60 °C to obtain soluble oligomers.
Shun Nakano +2 more
doaj +1 more source
Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
Molecules, 2013 The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores.
Thomas L. Mindt, Christiane A. Kluba
doaj +1 more source
Synthesis and properties of new fluorescent dyes and dye-labelled oligonucleotides
, 2012 Fluorescence is widely used in DNA sequencing and genetic analysis. Novel fluorescence techniques for studying nucleic acids and other biologically important molecules are constantly being developed.
Gerowska, Marta
core
Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides
Communications ChemistryBicyclic peptides exhibit improved metabolic stabilities and target specificities when compared to their linear or mono-cyclic counterparts; however, efficient and straightforward synthesis remains challenging due to their intricate architectures.
Masakazu Kobayashi +3 more
doaj +1 more source
Modification of a single-molecule AFM probe with highly defined surface functionality
Beilstein Journal of Nanotechnology, 2014 Single-molecule force spectroscopy with an atomic force microscope has been widely used to study inter- and intramolecular interactions. To obtain data consistent with single molecular events, a well-defined method is critical to limit the number of ...
Fei Long +4 more
doaj +1 more source
Regioselective Zn(OAc)2-catalyzed azide–alkyne cycloaddition in water: the green click-chemistry
, 2017 A new method of azide–alkyne cycloaddition (AAC) in the presence of Zn(OAc)2 as an inexpensive and environmentally friendly catalyst in neat water has been developed.
M. Morozova +9 more
semanticscholar +1 more source
Angewandte Chemie International Edition, EarlyView.π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero +11 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2017 An efficient, eco-compatible diversity-oriented synthesis (DOS) approach for the generation of library of sugar embedded macrocyclic compounds with various ring size containing 1,2,3-triazole has been developed.
Sushil K. Maurya, Rohit Rana
doaj +1 more source