Peptide Conjugation via CuAAC ‘Click’ Chemistry [PDF]
Molecules, 2013 The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or ‘click’ reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and ...
Abdullah A H Ahmad Fuaad +2 more
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Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates [PDF]
Nature CommunicationsCovalent transformations in biology follow defined temporal sequences that regulate processes such as acylation and phosphorylation, yet achieving comparable temporal control in synthetic systems remains challenging.
Debjyoti Bhattacharjee +6 more
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Site-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activity. [PDF]
PLoS ONE, 2014 Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient reaction linking an azido and an alkynyl group in the presence of copper catalyst. Incorporation of a non-natural amino acid (NAA) containing either an azido or an alkynyl group into a ...
Sung In Lim +4 more
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Held out wings RNA binding activity in the cytoplasm during early spermatogenesis [PDF]
Communications BiologyHeld out wings (HOW) is an RNA-binding protein essential for spermatogenesis in Drosophila melanogaster. HOW is a signal transduction and activation of RNA (STAR) protein, regulating post-transcriptional gene expression.
Michaela Agapiou +7 more
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Atroposelective interrupted CuAAC reaction using cyclic diaryliodoniums [PDF]
Nature CommunicationsCopper-catalyzed azide–alkyne cycloaddition (CuAAC) is a pivotal strategy for joining two fragments, including bioactive moieties under mild conditions.
Yuanyuan Li +3 more
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Molecules, 2016 The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule labeling and detecting. Of all the bioorthogonal reactions that have been developed, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is the most widely ...
Zhiyuan Zhang
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inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst [PDF]
Nature CommunicationsLabeling cellular biomolecules via copper-catalyzed azide–alkyne cycloaddition (CuAAC) offers rapid reaction kinetics and uses small azide and alkyne probes that minimally disturb molecular function, making it ideal for tracking biomolecules.
Keqing Nian +6 more
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Beilstein Journal of Organic Chemistry, 2022 The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated.
Laura Holzhauer +4 more
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CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview
Beilstein Journal of Organic Chemistry, 2023 Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
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A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
Frontiers in Chemistry, 2021 Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke +9 more
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