Results 1 to 10 of about 15,690 (247)
Click chemistry as a promising protocol for fluorogenic reactions [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 The Nobel prize in chemistry has been awarded to the click chemistry approach in 2022 due to its significant impact on nearly all fields of chemical science.
Heba Aref +4 more
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Beilstein Journal of Organic Chemistry, 2022 The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated.
Laura Holzhauer +4 more
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CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview
Beilstein Journal of Organic Chemistry, 2023 Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described.
Tereza Cristina Santos Evangelista +5 more
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A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
Frontiers in Chemistry, 2021 Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke +9 more
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Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors
Molecules, 2020 The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez +9 more
doaj +1 more source
Catalysis Communications, 2023 The demand for environmental friendly methodologies had shifted the the approach of scientific community for using easy and green reaction conditions instead of using hazardous and harsh reaction conditions.
Vijay Kumar +3 more
doaj +1 more source
Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation
Biomolecules, 2020 Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao +3 more
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Synthesis and CuAAC Reactions of Azidoalkylethoxysilanes: Grafting CuAAC Products onto Silica Surface [PDF]
Synthetic Communications, 2013 One-pot synthetic protocols of novel azido functionalized silane coupling agents from corresponding terminal mesylated or tosylated 1-olefins were developed. Azido groups were successfully converted to the corresponding 1,2,3-triazol ring by the copper-catalyzed azido alkyne coupling (CuAAC) reaction without alkoxysilane decomposition.
G. Kultyshev, Roman +3 more
openaire +1 more source
Huisgen-based conjugation of water-soluble porphyrins to deprotected sugars: Towards mild strategies for the labelling of glycans [PDF]
, 2014 Fully deprotected alkynyl-functionalised mono- and oligosaccharides undergo CuAAC-based conjugation with water-soluble porphyrin azides in aqueous environments.
Boyle, Ross W. +4 more
core +1 more source