Results 41 to 50 of about 11,111 (220)

NHC Polymeric Particles Obtained by Self-Assembly and Click Approach of Calix[4]Arene Amphiphiles as Support for Catalytically Active Pd Nanoclusters

Molecules, 2021
A new polymeric NHC carrier was synthesized by sequential supramolecular self-assembly and copper-catalyzed azide-alkyne cycloaddition (CuAAC) of amphiphilic imidazolium calix[4]arenes with octyl lipophilic fragments.
Vladimir Burilov, Diana Mironova, Elsa Sultanova, Ramila Garipova, Vladimir Evtugyn, Svetlana Solovieva, Igor Antipin   +6 more
doaj   +1 more source

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

Beilstein Journal of Organic Chemistry, 2013
The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly applicable and easy-to-handle reactions in the arsenal of organic chemistry.
Regina Berg, Bernd F. Straub
doaj   +1 more source

Mechanochemical Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). [PDF]

J Org Chem
Over the last 15 years, significant progress has been made in developing mechanochemical approaches for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, utilizing various starting materials and different copper sources and process parameters.
Kasprzak A.
europepmc   +3 more sources

Sustainable Construction of Heterocyclic 1,2,3-Triazoles by Strict Click [3+2] Cycloaddition Reactions Between Azides and Alkynes on Copper/Carbon in Water

Frontiers in Chemistry, 2019
1,4-Disubstituted-1,2,3-triazoles, considered as an important and useful class of heterocycles with potential applications in material science and biology, have been prepared in an efficient and selective manner by copper on carbon-catalyzed [3+2 ...
Noura Aflak, Hicham Ben El Ayouchia, Lahoucine Bahsis, El Mountassir El Mouchtari, Miguel Julve, Salah Rafqah, Hafid Anane, Salah-Eddine Stiriba, Salah-Eddine Stiriba   +8 more
doaj   +1 more source

Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

European Journal of Medicinal Chemistry Reports, 2023
Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of
Zaozao Xiao, Yuang Gu, Hewei Dong, Bo Liu, Weiwei Jin, Jie Li, Peixiang Ma, Hongtao Xu, Wei Hou   +8 more
doaj   +1 more source

A macrocyclic coumarin-containing tripeptide via CuAAC chemistry

Chemical Communications, 2009
A Cu-catalysed macrocyclisation was performed to obtain a macrocyclic coumarin-containing tripeptide for use in thrombin activity measurements.
Berkel, S.S. van, Lee, B. van der, Delft, F.L. van, Rutjes, F.   +3 more
openaire   +4 more sources

Synthesis of steroidal 16α-triazoles by CuAAc.

, 2015
Synthesis of steroidal 16α-triazoles by CuAAc.
Renáta Minorics (693374), Judit Molnár (218788), István Zupkó (297851), Zalán Kádár (693375), Imre Ocsovszki (445814), János Wölfling (693377), Éva Frank (693373), Bruno Schönecker (693376)   +7 more
core   +1 more source

Click'n ROPISA: One‐Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides

Angewandte Chemie, EarlyView.
Self‐assembly and fluorophore conjugation proceed rapidly in a one‐pot “Click'n ROPISA” process, yielding intensely fluorescent polypeptide nanoparticles with tunable visible emission. High dye loading enables efficient energy transfer and single‐particle visualization, while the straightforward synthesis provides versatile access to bright ...
Amin El Jarroudi Hammou, Juliette Lavainne, Rohit Mangalwedhekar, Jyothis Devasia, Laurent Cognet, Sébastien Lecommandoux, Colin Bonduelle, Chloé Grazon   +7 more
wiley   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie, EarlyView.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources