Results 41 to 50 of about 15,378 (241)

Azides and Porphyrinoids: Synthetic Approaches and Applications. Part 2—Azides, Phthalocyanines, Subphthalocyanines and Porphyrazines

Molecules, 2020
The reaction between organic azides and alkyne derivatives via the Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) is an efficient strategy to combine phthalocyanines and analogues with different materials.
Ana R. L. Araújo, Augusto C. Tomé, Carla I. M. Santos, Maria A. F. Faustino, Maria G. P. M. S. Neves, Mário M. Q. Simões, Nuno M. M. Moura, Sultan T. Abu-Orabi, José A. S. Cavaleiro   +8 more
doaj   +1 more source

Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

European Journal of Medicinal Chemistry Reports, 2023
Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of
Zaozao Xiao, Yuang Gu, Hewei Dong, Bo Liu, Weiwei Jin, Jie Li, Peixiang Ma, Hongtao Xu, Wei Hou   +8 more
doaj   +1 more source

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

Beilstein Journal of Organic Chemistry, 2013
The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly applicable and easy-to-handle reactions in the arsenal of organic chemistry.
Regina Berg, Bernd F. Straub
doaj   +1 more source

Sustainable Construction of Heterocyclic 1,2,3-Triazoles by Strict Click [3+2] Cycloaddition Reactions Between Azides and Alkynes on Copper/Carbon in Water

Frontiers in Chemistry, 2019
1,4-Disubstituted-1,2,3-triazoles, considered as an important and useful class of heterocycles with potential applications in material science and biology, have been prepared in an efficient and selective manner by copper on carbon-catalyzed [3+2 ...
Noura Aflak, Hicham Ben El Ayouchia, Lahoucine Bahsis, El Mountassir El Mouchtari, Miguel Julve, Salah Rafqah, Hafid Anane, Salah-Eddine Stiriba, Salah-Eddine Stiriba   +8 more
doaj   +1 more source

Isolation of bis(copper) key intermediates in Cu-catalyzed azide-alkyne "click reaction". [PDF]

, 2015
The copper-catalyzed 1,3-dipolar cycloaddition of an azide to a terminal alkyne (CuAAC) is one of the most popular chemical transformations, with applications ranging from material to life sciences.
Bertrand, Guy, Jin, Liqun, Melaimi, Mohand, Tolentino, Daniel R   +3 more
core   +2 more sources

Carbohydrate CuAAC click chemistry for therapy and diagnosis

Carbohydrate Research, 2016
Carbohydrates are important as signaling molecules and for cellular recognition events, therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug candidates. As a consequence, the construction of carbohydrate-based bioactive compounds and sensors has become an active research area. While the advent of click chemistry has
He, Xiao Peng, Zeng, Ya Li, Zang, Yi, Li, Jia, Field, Robert A., Chen, Guo Rong   +5 more
openaire   +3 more sources

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

Angewandte Chemie, EarlyView.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova, Manisha B. Walunj, Claudia Höbartner   +2 more
wiley   +2 more sources

Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs. [PDF]

, 2020
The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described.
Deming, Timothy J, Gharakhanian, Eric G, Negri, Graciela E   +2 more
core   +1 more source