Results 41 to 50 of about 15,690 (247)

CuAAC reactions of sterically hindered azides

Visnyk of the Lviv University. Series Chemistry, 2020
The regularities of the CuAAC reactions due to the structure of the substituent were determined and basic requirements for the choice of the catalytic system in the case of azides or alkynes with bulky substituents, and azides containing fragments able to effectively act on Cu(I) ions were shown.
R. Savka, N. Pokhodylo, M. Tupychak, O. Shyyka, M. Obushak   +4 more
openaire   +2 more sources

Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions

Molecules, 2016
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Xiaoguang Zhang, Peiye Liu, Lei Zhu
doaj   +1 more source

Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

European Journal of Medicinal Chemistry Reports, 2023
Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of
Zaozao Xiao, Yuang Gu, Hewei Dong, Bo Liu, Weiwei Jin, Jie Li, Peixiang Ma, Hongtao Xu, Wei Hou   +8 more
doaj   +1 more source

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

Beilstein Journal of Organic Chemistry, 2013
The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly applicable and easy-to-handle reactions in the arsenal of organic chemistry.
Regina Berg, Bernd F. Straub
doaj   +1 more source

Sustainable Construction of Heterocyclic 1,2,3-Triazoles by Strict Click [3+2] Cycloaddition Reactions Between Azides and Alkynes on Copper/Carbon in Water

Frontiers in Chemistry, 2019
1,4-Disubstituted-1,2,3-triazoles, considered as an important and useful class of heterocycles with potential applications in material science and biology, have been prepared in an efficient and selective manner by copper on carbon-catalyzed [3+2 ...
Noura Aflak, Hicham Ben El Ayouchia, Lahoucine Bahsis, El Mountassir El Mouchtari, Miguel Julve, Salah Rafqah, Hafid Anane, Salah-Eddine Stiriba, Salah-Eddine Stiriba   +8 more
doaj   +1 more source

Azides and Porphyrinoids: Synthetic Approaches and Applications. Part 2—Azides, Phthalocyanines, Subphthalocyanines and Porphyrazines

Molecules, 2020
The reaction between organic azides and alkyne derivatives via the Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) is an efficient strategy to combine phthalocyanines and analogues with different materials.
Ana R. L. Araújo, Augusto C. Tomé, Carla I. M. Santos, Maria A. F. Faustino, Maria G. P. M. S. Neves, Mário M. Q. Simões, Nuno M. M. Moura, Sultan T. Abu-Orabi, José A. S. Cavaleiro   +8 more
doaj   +1 more source

Modulating the Swelling Behavior of Polymer Brushes via Interfacial Chemistry

Angewandte Chemie, EarlyView.
Modulating substrate surface chemistry of surface‐grafted polymer brushes via variation of the chemical composition of spacers that anchor initiators for surface‐initiated atom transfer polymerizations allows to tune swelling of these thin polymer films.
Kuljeet Kaur, Sabrina Sant, Leon A. Smook, Sissi de Beer, Harm‐Anton Klok   +4 more
wiley   +2 more sources

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes [PDF]

, 2016
Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, the regioselective oxygenation of ...
Aizpurua Iparraguirre, Jesús María, Correa Navarro, Arkaitz, Irastorza Epelde, Aitziber   +2 more
core   +2 more sources