Results 51 to 60 of about 15,690 (247)
A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells
Angewandte Chemie, EarlyView.A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim +7 more
wiley +2 more sources
Advanced Functional Materials, EarlyView.Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong +5 more
wiley +1 more source
Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation
Angewandte Chemie, EarlyView.The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu +12 more
wiley +2 more sources
Coordinatively unsaturated ruthenium complexes as efficient alkyne-azide cycloaddition catalysts [PDF]
, 2012 The performance of 16-electron ruthenium complexes with the general formula Cp*Ru(L)X (in which L = phosphine or N-heterocyclic carbene ligand; X = Cl or OCH2CF3) was explored in azide−alkyne cycloaddition reactions that afford the 1,2,3- triazole ...
Broggi, Julie +6 more
core +2 more sources
Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials
Advanced Materials, EarlyView.A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella +3 more
wiley +1 more source
Reduced Symmetry Metal–Organic Cage‐to‐Framework Materials
Angewandte Chemie, EarlyView.A series of Ag(I) MOFs was synthesised from organic cages of varying structure and symmetry as linkers. Minor variations in the cage linkers were shown to significantly influence the structures of the resulting MOFs. This work represents the first incorporation of reduced symmetry (including chiral), intrinsically porous building blocks into MOFs, and ...
Cameron J. T. Cox +5 more
wiley +2 more sources
Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]
, 2018 Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn +2 more
core +1 more source
Nanomaterial Integration at Liquid–Liquid Interfaces for Green Catalysis
Advanced Materials, EarlyView.Functional nanomaterials assembled at liquid–liquid interfaces create dual‐role platforms serving as emulsion stabilizers and catalytic sites, offering enhanced reaction kinetics with improved catalyst recovery and recyclability. This review examines design strategies, structure‐performance relationships, and industrial implementation prospects of ...
Bokgi Seo +6 more
wiley +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Development of Novel Immobilized Copper–Ligand Complex for Click Chemistry of Biomolecules
MoleculesCopper-catalyzed azide–alkyne cycloaddition click (CuAAC) reaction is widely used to synthesize drug candidates and other biomolecule classes. Homogeneous catalysts, which consist of copper coordinated to a ligand framework, have been optimized for high ...
Rene Kandler +7 more
doaj +1 more source