Results 31 to 40 of about 15,690 (247)

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]

, 2014
The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W., Bryden, Francesca, Caddick, Stephen, Chudasama, Vijay, Maruani, Antoine, Savoie, Huguette, Smith, Mark E. B.   +6 more
core   +1 more source

Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions [PDF]

, 2012
We present novel homobifunctional amine-reactive clickable cross-linkers (CXLs) for investigation of three-dimensional protein structures and protein–protein interactions (PPIs).
Agnew, Heather D., Beauchamp, J. L., Czerwieniec, Gregg, Deshaies, Raymond J., Graham, Robert L. J., Heath, James R., Hess, Sonja, Lee, J. Eugene, Loo, Joseph A., Smith, Geoffrey T., Sohn, Chang Ho, Sweredoski, Michael J.   +11 more
core   +2 more sources

Polymeric Blatter's Radical via CuAAC and ROMP [PDF]

Macromolecular Chemistry and Physics, 2021
AbstractA Blatter radical‐containing polymer backbone is synthesized via copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) and consecutive ring‐opening metathesis polymerization. For this, an alkyne‐functionalized Blatter radical is synthesized and used for the described CuAAC, yielding a polymerizable derivative of the radical. The resulting polymer
Adrian Saal, Christian Friebe, Ulrich S. Schubert   +2 more
openaire   +1 more source

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]

, 2016
We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N., O’Hagan, David, Thompson, Stephen   +2 more
core   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

NHC Polymeric Particles Obtained by Self-Assembly and Click Approach of Calix[4]Arene Amphiphiles as Support for Catalytically Active Pd Nanoclusters

Molecules, 2021
A new polymeric NHC carrier was synthesized by sequential supramolecular self-assembly and copper-catalyzed azide-alkyne cycloaddition (CuAAC) of amphiphilic imidazolium calix[4]arenes with octyl lipophilic fragments.
Vladimir Burilov, Diana Mironova, Elsa Sultanova, Ramila Garipova, Vladimir Evtugyn, Svetlana Solovieva, Igor Antipin   +6 more
doaj   +1 more source

Flow Chemistry Meets Green Solvents: Telescoped Synthesis of Triazolyl Phosphoramidates and Phosphinamides in γ-Valerolactone. [PDF]

ChemSusChem
A telescoped three‐step continuous flow process enables the synthesis of organophosphorus 1,2,3‐triazoles in the biomass‐derived solvent γ‐valerolactone (GVL). The sequence integrates N‐phosphorylation, azidation, and Cu(I)‐catalyzed azide–alkyne cycloaddition (CuAAC), followed by in‐line copper removal, giving diverse triazoles in good to high overall
Gerő V, Steinsits D, Szabó PT, Bálint E.   +3 more
europepmc   +2 more sources

Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs. [PDF]

, 2020
The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described.
Deming, Timothy J, Gharakhanian, Eric G, Negri, Graciela E   +2 more
core   +1 more source

Responsive glyco-poly(2-oxazoline)s: synthesis, cloud point tuning, and lectin binding [PDF]

, 2011
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well as 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers with ...
Adams N., Ambrosi M., Aoi K., Aoi K., Aoi K., Aoi K., Bassiri T. G., Bloksma M. M., Campos L. M., Cesana S., Christine Weber, Christova D., Collins B. E., Cortez M. A., Diehl C., Dimick S. M., Gabius H. J., Hoogenboom R., Hoogenboom R., Huber S., Kagiya T., Kempe K., Kempe K., Knop K., Kobayashi S., Kobayashi S., Kobayashi S., Kristian Kempe, Krzysztof Babiuch, Lambermont-Thijs H. M. L., Lin P. Y., Lundquist J. J., Michael Gottschaldt, Mikata Y., Narain R., Richard Hoogenboom, Saegusa T., Saegusa T., Seeliger W., Slavin S., Stillman B. N., Takasu A., Taubmann C., Ting S. R. S., Tomalia D. A., Tsutsumiuchi K., Ulrich S. Schubert, Vazquez-Dorbatt V., Weber C., Wiesbrock F., Wiesbrock F., Witte H.   +51 more
core   +2 more sources

Carbohydrate CuAAC click chemistry for therapy and diagnosis

Carbohydrate Research, 2016
Carbohydrates are important as signaling molecules and for cellular recognition events, therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug candidates. As a consequence, the construction of carbohydrate-based bioactive compounds and sensors has become an active research area. While the advent of click chemistry has
He, Xiao Peng, Zeng, Ya Li, Zang, Yi, Li, Jia, Field, Robert A., Chen, Guo Rong   +5 more
openaire   +3 more sources