Results 11 to 20 of about 15,378 (241)
A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations [PDF]
Molecules, 2015 We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc ...
Benjamin Fabre +4 more
doaj +3 more sources
A flow platform for degradation-free CuAAC bioconjugation [PDF]
Nature Communications, 2018 Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use.
Marine Z. C. Hatit +5 more
doaj +6 more sources
Polypropylene-based graft copolymers via CuAAC click chemistry
eXPRESS Polymer Letters, 2018 Graft copolymers from commercial chlorinated polypropylene (PP-Cl) possessing either poly(ethylene glycol) (PEG) or poly(ε-caprolactone) (PCL) grafts are synthesized by copper (I)-catalyzed azide-alkyne cycloaddition ‘click’ reaction (CuAAC).
G. Acik, E. Sey, M. A. Tasdelen
doaj +5 more sources
AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides [PDF]
Journal of the American Chemical Society, 2020 We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
Amanda Acevedo-Jake +7 more
openaire +6 more sources
Synthesis and CuAAC Reactions of Azidoalkylethoxysilanes: Grafting CuAAC Products onto Silica Surface [PDF]
Synthetic Communications, 2013 One-pot synthetic protocols of novel azido functionalized silane coupling agents from corresponding terminal mesylated or tosylated 1-olefins were developed. Azido groups were successfully converted to the corresponding 1,2,3-triazol ring by the copper-catalyzed azido alkyne coupling (CuAAC) reaction without alkoxysilane decomposition.
Kultyshev, Roman G. +3 more
openaire +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described.
Tereza Cristina Santos Evangelista +5 more
doaj +1 more source
Catalysis Communications, 2023 The demand for environmental friendly methodologies had shifted the the approach of scientific community for using easy and green reaction conditions instead of using hazardous and harsh reaction conditions.
Vijay Kumar +3 more
doaj +1 more source
Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors
Molecules, 2020 The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez +9 more
doaj +1 more source
Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation
Biomolecules, 2020 Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao +3 more
doaj +1 more source
Cationic Copper Iminophosphorane Complexes as CuAAC Catalysts: A Mechanistic Study [PDF]
Organometallics, 2020 We have combined Cu K-edge X-ray absorption spectroscopy with NMR spectroscopy (1H and 31P) to study the Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction under operando conditions. A variety of novel, well-defined CuI iminophosphorane complexes were prepared.
Bas Venderbosch +4 more
openaire +4 more sources