Results 21 to 30 of about 11,111 (220)
Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates. [PDF]
Angew Chem Int Ed EnglAn alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Cho YT +5 more
europepmc +3 more sources
AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides [PDF]
Journal of the American Chemical Society, 2020 We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
Amanda Acevedo-Jake +7 more
openaire +5 more sources
CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview
Beilstein Journal of Organic Chemistry, 2023 Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
doaj +1 more source
A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
Frontiers in Chemistry, 2021 Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke +9 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described.
Tereza Cristina Santos Evangelista +5 more
doaj +1 more source
Catalysis Communications, 2023 The demand for environmental friendly methodologies had shifted the the approach of scientific community for using easy and green reaction conditions instead of using hazardous and harsh reaction conditions.
Vijay Kumar +3 more
doaj +1 more source
Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors
Molecules, 2020 The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez +9 more
doaj +1 more source
Site-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activity. [PDF]
PLoS ONE, 2014 Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient reaction linking an azido and an alkynyl group in the presence of copper catalyst. Incorporation of a non-natural amino acid (NAA) containing either an azido or an alkynyl group into a ...
Sung In Lim +4 more
doaj +1 more source
Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation
Biomolecules, 2020 Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao +3 more
doaj +1 more source
A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine [PDF]
, 2017 A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC ...
Hatit, Marine Z. C. +3 more
core +4 more sources