Results 21 to 30 of about 11,349 (193)

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors

Molecules, 2020
The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez, Bruno Di Geronimo, Miryam Pastor, José María Zapico, Claire Coderch, Rostyslav Panchuk, Nadia Skorokhyd, Maciej Maslyk, Ana Ramos, Beatriz de Pascual-Teresa   +9 more
doaj   +1 more source

Site-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activity. [PDF]

PLoS ONE, 2014
Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient reaction linking an azido and an alkynyl group in the presence of copper catalyst. Incorporation of a non-natural amino acid (NAA) containing either an azido or an alkynyl group into a ...
Sung In Lim, Yukina Mizuta, Akinori Takasu, Yong Hwan Kim, Inchan Kwon   +4 more
doaj   +1 more source

Evidence for a Cu(II)-Catalysed CuAAC Reaction: A Combined Experimental and Computational Study. [PDF]

Angew Chem Int Ed Engl
A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Andrews MJ, Richardson TM, Roberts DD, Maestro A, Hilton TA, Sotorrios L, Martín-Fernández C, Craciunescu L, Peschke F, McKay AP, Macgregor SA, Burley GA, Watson AJB.   +12 more
europepmc   +3 more sources

Cationic Copper Iminophosphorane Complexes as CuAAC Catalysts: A Mechanistic Study [PDF]

, 2020
We have combined Cu K-edge X-ray absorption spectroscopy with NMR spectroscopy (1H and 31P) to study the Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction under operando conditions.
Venderbosch, Bas, Korstanje, Ties J., Tromp, Moniek, van der Vlugt, Jarl Ivar, Oudsen, Jean-Pierre H., Tromp, Moniek (author), Tromp, M., Venderbosch, Bas (author), Korstanje, Ties J. (author), Venderbosch, B., Oudsen, Jean Pierre H. (author), Korstanje, T.J., Oudsen, J.-P.H., van der Vlugt, J.I., van der Vlugt, Jarl Ivar (author)   +14 more
core   +3 more sources

Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation

Biomolecules, 2020
Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao, Ann C. Lee, Karl É. Racine, Jeffrey W. Keillor   +3 more
doaj   +1 more source

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

, 2022
Copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended “click” scaffolds with the potential for selective metal ion recognition.
Harminder Singh (743205), Jandeep Singh (13988258), Nancy George (11407085), Jashan Deep Kaur (13988255), Gurleen Singh (13988249), Riddima Singh (13988252), Gurjaspreet Singh (588997), Gurpreet Kaur (515531)   +7 more
core   +1 more source

A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine [PDF]

, 2017
A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC ...
Hatit, Marine Z. C., Burley, Glenn A., Seath, Ciaran P., Watson, Allan J. B.   +3 more
core   +3 more sources

Biocompatible photoinduced CuAAC using sodium pyruvate

, 2021
Sodium pyruvate, a natural intermediate produced during cellular metabolism, is commonly used in buffer solutions and media for biochemical applications.
Szczepaniak G., Yerneni S. S., Jeong J., Lorandi F., Matyjaszewski K., Lathwal S., Das S. R., Jafari H., Sushil Lathwal, Krzysztof Matyjaszewski, Francesca Lorandi, Jaepil Jeong, Grzegorz Szczepaniak, Hossein Jafari, Subha R. Das, Saigopalakrishna S. Yerneni   +15 more
core   +1 more source

Recent syntheses of steroid derivatives using the CuAAC “click” reaction

, 2021
International audienceThe introduction of heterocycles into steroids is often at the origin of a modification of their physiological activity and thus allows the formation of new biologically interesting molecules. Recent advances in the field of steroid
Dumur, Frédéric, Ibrahim-Ouali, Malika, Frédéric Dumur, Malika Ibrahim-Ouali   +3 more
core   +1 more source

Exfoliated black phosphorous-mediated CuAAC chemistry for organic and macromolecular synthesis under white LED and near-IR irradiation

Beilstein Journal of Organic Chemistry, 2021
The development of long-wavelength photoinduced copper-catalyzed azide–alkyne click (CuAAC) reaction routes is attractive for organic and polymer chemistry.
Azra Kocaarslan, Zafer Eroglu, Önder Metin, Yusuf Yagci   +3 more
doaj   +1 more source