Results 61 to 70 of about 11,349 (193)

Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction

, 2016
Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper(Ι)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits
Seijiro Matsubara (1490731), Keisuke Asano (1592053)   +1 more
core   +1 more source

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

Beilstein Journal of Organic Chemistry, 2018
A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported.
Muhammad Israr, Changqing Ye, Munira Taj Muhammad, Yajun Li, Hongli Bao   +4 more
doaj   +1 more source

Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammonia

, 2012
Copper(I) catalysed azide–alkyne cycloaddition reactions (CuAAC) occur smoothly in liquid ammonia (LNH3) at room temperature to give exclusively 1,4-substituted 1,2,3-triazoles with excellent yields (up to 99%).
Ji, Pengju, Page, Michael I., Atherton, John, Page, Michael, Atherton, John H.   +4 more
core   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst

Nature Communications
Labeling cellular biomolecules via copper-catalyzed azide–alkyne cycloaddition (CuAAC) offers rapid reaction kinetics and uses small azide and alkyne probes that minimally disturb molecular function, making it ideal for tracking biomolecules.
Keqing Nian, Yifang Liu, Yuchen Qiu, Zhuoyu Zhang, Laura Brigandi, Meni Wanunu, Sara H. Rouhanifard   +6 more
doaj   +1 more source

Solvent-Free Copper-Catalyzed Azide-Alkyne Cycloaddition under Mechanochemical Activation

Molecules, 2015
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e., milling time, revolutions/min, size and milling ball number) have been
Laura Rinaldi, Katia Martina, Francesca Baricco, Laura Rotolo, Giancarlo Cravotto   +4 more
doaj   +1 more source

Regio- and Diastereoselective Synthesis of β‑Lactam-Triazole Hybrids via Passerini/CuAAC Sequence

, 2016
Passerini (P-3CR) and Passerini–Smiles reactions were investigated in azetidine-2,3-diones, affording the corresponding 3,3-disubstituted-β-lactams with complete diastereoselectivity in high yields.
Benito Alcaide (1554658), Cristina Aragoncillo (1771678), Pedro Almendros (1554667), Ricardo Callejo (1896721), M. Rosario Torres (1554670), M. Pilar Ruiz (1554499)   +5 more
core   +2 more sources

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Star-shaped polyacrylates : highly functionalized architectures via CuAAc click conjugation

, 2009
Well-defined functional star-shaped polymer structures with up to 29 arms have been successfully synthesized by the combination of atom transfer radical polymerization (ATRP) and click chemistry.
Richard Hoogenboom, Du Prez, Filip, Hoogenboom, R., Du Prez, F.E., Lammens, M., Martin W. M. Fijten, Hoogenboom, Richard, Fijten, M.W.M., Fijten, Martin WM, Fournier, D.J.R., Filip Du Prez, Mieke Lammens, Fournier, David, David Fournier, Lammens, Mieke   +14 more
core   +1 more source

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source