Results 71 to 80 of about 11,111 (220)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes

Angewandte Chemie, EarlyView.
A strategy for accelerated photochemical reaction discovery is reported that harnesses the dynamic speciation of copper complexes, driven by their labile metal–ligand bonds. This platform simplifies reaction screening by combining an earth‐abundant copper(II) salt with commercially available ligands, which reversibly generate multiple catalytic species
Alessio Regni, Siyu Liang, Supreeta Sen, Hailey Hendricks, Xijue Wu, Matthew V. Pecoraro, Jose B. Roque   +6 more
wiley   +2 more sources

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

Beilstein Journal of Organic Chemistry, 2018
A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported.
Muhammad Israr, Changqing Ye, Munira Taj Muhammad, Yajun Li, Hongli Bao   +4 more
doaj   +1 more source

Supramolecular Polymer‐Surfactant Co‐Assemblies for Multivalent HSV‐1 Inhibition

Angewandte Chemie, EarlyView.
Non‐covalent co‐assembly of BTA with antiviral surfactants produces ratio‐dependent morphologies. Fibrous supramolecular polymers exhibit superior HSV‐1 inhibition, revealing multivalent fiber‐virus interactions and highlighting supramolecular co‐assemblies as a powerful strategy for functional biomedical nanomaterials with demonstrated tunable ...
Christian Zoister, Boris Schade, Paulina Sittinger, Xianwen Lou, Esmee de Korver, Freek V. de Graaf, Ranen Etouki, Chuanxiong Nie, Kai Licha, Kai Ludwig, Abhishek Kumar Singh, E. W. Meijer, Rainer Haag   +12 more
wiley   +2 more sources

Solvent-Free Copper-Catalyzed Azide-Alkyne Cycloaddition under Mechanochemical Activation

Molecules, 2015
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e., milling time, revolutions/min, size and milling ball number) have been
Laura Rinaldi, Katia Martina, Francesca Baricco, Laura Rotolo, Giancarlo Cravotto   +4 more
doaj   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst

Nature Communications
Labeling cellular biomolecules via copper-catalyzed azide–alkyne cycloaddition (CuAAC) offers rapid reaction kinetics and uses small azide and alkyne probes that minimally disturb molecular function, making it ideal for tracking biomolecules.
Keqing Nian, Yifang Liu, Yuchen Qiu, Zhuoyu Zhang, Laura Brigandi, Meni Wanunu, Sara H. Rouhanifard   +6 more
doaj   +1 more source

Polymeric Micellar Nanocatalysts for CuAAC Click Reaction in Water

Langmuir
Polymer-supported copper catalysts have attained a prominent status and continue to be a focal point of ongoing research and development due to their adaptable properties, which make them invaluable tools for diverse catalytic reactions in aqueous solutions.
Witsanu Sombat, Panuwat Padungros, Voravee P. Hoven   +2 more
openaire   +2 more sources

‐lactide) copolymers by CuAAC click chemistry

, 2018
Altinkok, Cagatay (Trakya author)The syntheses of polypropylene-graft-poly(l-lactide) copolymers (PP-g-PLAs) via copper (I)-catalyzed azide-alkyne cycloaddition "click" reaction (CuAAC) using azide side-chain functionalized polypropylene (PP-N-3) and ...
Mehmet Atilla Tasdelen, Cagatay Altinkok, Altinkok, Cagatay, Acik, Gokhan, Tasdelen, Mehmet Atilla, Gokhan Acik   +5 more
core   +1 more source

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins [PDF]

, 2018
In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms.
Wagstaff, Ben A., Saalbach, Gerhard, Field, Robert A., Field, Robert A.; id_orcid, Hems, Edward S.   +4 more
core   +1 more source