Results 71 to 80 of about 11,349 (193)
Synthesis and application of some novel functional polymers via controlled radical polymerization and click chemistry [PDF]
The objective of this thesis was to prepare thermoresponsive PEG-based homopolymers and copolymers by combination of cobalt-mediated catalytic chain-transfer polymerization (CCTP) and thiol-ene “click” chemistry and prepare well-defined glycopolymers ...
Li, Guang-Zhao
core
Stepwise, Protecting Group Free Synthesis of [4]Rotaxanes
Molecules, 2017 Despite significant advances in the last three decades towards high yielding syntheses of rotaxanes, the preparation of systems constructed from more than two components remains a challenge.
James E. M. Lewis +2 more
doaj +1 more source
Arylazopyrazoles for Conjugation by CuAAC Click Chemistry
Molecular photoswitches are increasingly being implemented in bioactive compounds and responsive materials. For this purpose, photoswitches must be coupled to a wide variety of substrates and scaffolds.
Rebecca Niebuhr (18368467) +2 more
core +1 more source
Dinuclear thiazolylidene copper complex as highly active catalyst for azid–alkyne cycloadditions
Beilstein Journal of Organic Chemistry, 2016 A dinuclear N-heterocyclic carbene (NHC) copper complex efficiently catalyzes azide–alkyne cycloaddition (CuAAC) “click” reactions. The ancillary ligand comprises two 4,5-dimethyl-1,3-thiazol-2-ylidene units and an ethylene linker.
Anne L. Schöffler +3 more
doaj +1 more source
Fluorophore-Assisted Click Chemistry through Copper(I) Complexation
Biomolecules, 2020 The copper-catalyzed alkyne-azide cycloaddition (CuAAC) is one of the most powerful chemical strategies for selective fluorescent labeling of biomolecules in in vitro or biological systems. In order to accelerate the ligation process and ensure efficient
Victor Flon +5 more
doaj +1 more source
Chemistry ProceedingsBis-heterocyclic compounds containing imidazo[1,2-a]pyridines (IMPs) are privileged heterocyclic drug scaffolds due to their potential applications. The Groebke–Blackburn–Bienaymé reaction (GBBR) is a greener alternative to synthesizing IMPs.
Manuel A. Rentería-Gómez +4 more
doaj +1 more source
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Selective Chemical Modification of DNA with Boronic Acids by On-Column CuAAc Reactions
, 2020 International audienceThe use of the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the preparation of oligonucleotide conjugates is by now familiar.
Debiais, Mégane +3 more
core +1 more source
A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation
Angewandte Chemie International Edition, EarlyView.The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf +4 more
wiley +1 more source
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source